Conserved Protein Domain Family
MutS2

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COG1193: MutS2 
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair]
Statistics
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PSSM-Id: 440806
Aligned: 358 rows
Threshold Bit Score: 635.259
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_111335463   1 MmnsdqnsdaqpaakDissytsleglmvqtlapvrggaprgegddasseswrraifpPKTLQDLQWPRLLAML-EKEAST 79 
WP_004512907   1 Mi-------------R-----------------------------------------HETLRTLEFDKVLAAV-GGYGHS 25 
WP_011736768   1 Mi-------------S-----------------------------------------HQTLKRLEFDKILAEI-SGHVHS 25 
YP_002247978   1 Mi-------------E-----------------------------------------KKALQELDFYKILGLI-EEFAGS 25 
YP_003317249   1 Mr------------cD-----------------------------------------PNTYRVLEIEKALAIV-AGRCRS 26 
WP_083775766  16 Mk------------vR-----------------------------------------KEVWNLLEIDKILSIF-AKSLRS 41 
WP_013638390   1 Mf-------------------------------------------------------KGVGYHLEFNKILKAT-SELAKS 24 
WP_081468084   1 Mkav---------ktD-----------------------------------------AKTLQLVDIPKVLELI-EKECRS 29 
WP_014806770   1 Mi------------sS-----------------------------------------KQTRQLLEIDKIIAKFySKNIRS 27 
WP_066745550   1 Mf------------iE-----------------------------------------KAAYSSLEISKVMELV-SRRCRS 26 
WP_111335463  80 PEGRAILADLQPLPTRAGIERRLAETGEALRLLADDDFPPL-MGLRDIRRALDHVS-RQGVLLGEDLAAIARNCDVGARN 157
WP_004512907  26 TATQDEIALIRPLDDWSAITRRFGQVDEIRRMTQQGIAIPL-STFDDISALLDAVRpEGAVLDPTELVILFPVLRTMTAI 104
WP_011736768  26 EVTAARLMDTVPLSDGGAIASISGRIEEIRSLASQGIALRL-QPFQDIRPLMELLRpVGAFLGPRELLIFIPVLEIFGDI 104
YP_002247978  26 EATKKAIQQIFPFDEFTSAENSLKEFEEIKRYFDTGGQLQI-SSFPDIANLIEKAKkEGAFFEPSELTQFLKVLRVLDKI 104
YP_003317249  27 ELGVARAFRSSPARDVESLRRRFDLLRAYSSAVARRGDYPWdQRVTPMEGLVRDAK-TYGWLNGQELVKVRNSLILSSRI 105
WP_083775766  42 DLGLSVLTAITPCETIDTLRNRQNLLIAYRDYVDRYGDFPWnQNVSSVAEEIHAAR-KTALLTGQELVAVRMLLLLATRI 120
WP_013638390  25 EPGKSATLSLVPLTKREEVERNLRITDTLVKLL-SEKQLPL-ESFPDISKTINKLSvEGAILSVEELVSILKVIRQSSIL 102
WP_081468084  30 PLGVLCLREQEPLPSIQHVEERQALFVSFCKYEDVCGRLPWeKDLNPLGRLFEDAK-VSGLLSGVELVHIRNMVGLAIRI 108
WP_014806770  28 EIGKTYVRDIKPLTNIEALKDWQALYREFERYIDVKGDFPWdDRLMPIGDLLEAGK-SQGVLFGEELLPFKCMLGLAVRI 106
WP_066745550  27 EIGALVARNIAPAFDMAELKRRQALYMDVERYRGYKGELPWiNDIVSVAFMLEMAE-ENGLLSGEELVKIRLLLTLSGRM 105
WP_111335463 158 YRFFESR-GGRFPLLAEAGAQI--DPV----DRLRAELHECVDPSGELTDRASPALRTLRRNVQNQHDRLRSRIEQELGR 230
WP_004512907 105 AKQFA-Y-RSDIPLLKELAGHV--TGF----PDILDELEVSIDSEGEILDSASPLLFDLRKKKRALTERIRRRLAEIVRE 176
WP_011736768 105 ARQFAP--RNDIPLLKGLDPPL--KGF----ADILEPLAASIDQDGGIMDSASTALREIRRAKRSLASRIRKKIEEIVRD 176
YP_002247978 105 SSYIDEF--FNFPFLSQKIKNIlkTNLsigqPYILERLENTVDEEGNILDTASSTLKYIRKQIKLTEEKIKQKLEEIINR 182
YP_003317249 106 KVRLKED-CSEFEALRDLLRHF--PDW----EEELGRL-EVLDEDGALYDGASTKLKELRFKGRELRSLARQRWNEILSN 177
WP_083775766 121 KDVLNQV-KDEFAPFAGVLKKI--RDF----KYEIESL-AVLDEDGNLFDSATPTLLRIRKSEEAVRQSIRLRAQALFAN 192
WP_013638390 103 KNFFSSL-DERFSRIKYFGERL--SRF----EGLREVLERSIDDTGEILDTASPRLKSIRKNIRVTTLRIREKLESLVNR 175
WP_081468084 109 KDVVSDR-KDAFAELYSLTRRI--PDL----SELFDDL-HVLADDGRLYDRASELLGRLRSAHRDYAAKARKAAQNLVSN 180
WP_014806770 107 KELSGELaREGYGKLGEMARQF--ADF----GDEVKAM-SVVDEDGRLYDSASVKLAEIRNELDVAKRQARSIGQKIISD 179
WP_066745550 106 RDALSAA-REEYPNFGILLRDM--RDF----SE-EARMLAVIDDDGHLYDYASEKLSALRQQMRGLKDTVRRRGHALLND 177
WP_111335463 231 EELADYLQDDYFTVREERYVLPIRSSARSHVPGVVHGYSSSGQTAFIEPADLVNLNNELRWAEAELQEEKNRIFARLSAQ 310
WP_004512907 177 TGVTTFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVAEEKAEMIRIVRAICRM 256
WP_011736768 177 NNIEIFLQDDFITQRSGRWVIPVRMDSKGMVKGVVHDVSSSGETAFMEPLEIIPFVNELENLSAEEKAEEIRILRQLSSW 256
YP_002247978 183 SNVLVFLQDRFITKRNNRWVIPVRMDSKGQIPGVVHDVSRSGETAFIEPAEITAFSKKLEELLIEQRLEEIKILKELSFE 262
YP_003317249 178 GSLASMLQDRVLTLRNGRFCALVRLDMAGSFPGLVVERSSSGNSVYVEPAPILPLNNRMAVIAGEEREEEQRILRALTEM 257
WP_083775766 193 SRINNMLQERLLTFRQNRFTVLVRQEFASRFPGTFIDRSGSGNSVYMEPRSLAELNSRLVLLIQDEEEEKRRILSELTQM 272
WP_013638390 176 Y--EDLCPDRIVTEREGRYVILVKPHFRKKFSGIVHDRSSSGQTLYVEPASVIEDNNRLRELKAEEKEEIKRILIELSWK 253
WP_081468084 181 PSVSSMLQDKNVHYRKGRIVLLVRQENLHKFRGIVIDRSSSGNSLYMEPEGLIEINNRVSILEKEIEEEERRILRSLTRK 260
WP_014806770 180 QSLSSKLQDQVIAMRNGRYVLLVKKDLAPSFPGIFVDYSSSGNSVYMEPHALVTMNNKIAMLLEDERREERRICQKLTEM 259
WP_066745550 178 PAIAGMLQERVLTLRNGRYAFLVRQDALSQFPGSVIDRSGSGNSVYMEPRSLLSLNNEYSKLYGEEMLEETRIFREFTAK 257
WP_111335463 311 VGQYAASLLHNSDCLAYIDVVMAHARFAERINATVPTIT-EDRVELKQLRHPMLYvqhlrerdgqltSDVVANDLILEPE 389
WP_004512907 257 LRREADPLAEQFRTLVHLDLLNAVATFADSLSAENPEINdARFIRVNEGRHPLLAlmar----ergaGRVVPLDLSLGET 332
WP_011736768 257 IRQDAAEISACFETLLTLDELASIARFADTHALEPPSLNgEGVLRLAGARHPLLLmlqa----qgalSRVEPLDLQLGGE 332
YP_002247978 263 IHQISETLHREFNLLVYLDKMLSIYKFSQKFNAEAPQLTrEINISLINAKHPLLLl----------sKQVVPLNLELK-N 331
YP_003317249 258 LLSREGALLETDRGLGYLDLLNAQVELLSESSWVVPEVSnDRSFKLRSARHPLLG------------ERAVPLDVSCGEH 325
WP_083775766 273 ILGREKAIVDAEGVLGQIDILYALTDVMGKYGWTLPELSkKPFFVFYDLLHPLLG------------EKGIPLTIECGRS 340
WP_013638390 254 VSERRVELLTSFRTLIELDRRYATALLSLKLKGTLPEFSe--EIDLKEAKHPLILls---------eKEVVPVDIKLK-- 320
WP_081468084 261 VLMKQKLLERTEQVLGLLDLMYALREVARKDRWSLPLMKnSPMLKLKGARHPLLG------------KQCVPIDIFCGTS 328
WP_014806770 260 LLSRERAILKAQDLIGQIDLMWGIYYFLQANDWTLPEMEeKSSFYLNNAHHPLLE------------PKAVPIDVHCGRN 327
WP_066745550 258 LINRKKGIIDTENVLGTVDLFYALSEMTRIYKWRLPDLDpRTLFSFVSARHPLLG------------DRSVPIEIRCGGD 325
WP_111335463 390 RRILLISGPNTGGKTVLLKSFGLCALMLHFGLPIPV-AEGSKIPLFDSIFSDIGDEQSIERDLSTFSSHLTNINEFLGEC 468
WP_004512907 333 EQVMVITGPNAGGKTISLKTTGLLHLMALAGLPVPA-ASTSSFPLISDLLVDIGDEQSIEQSLSTFSAHVSNIAGILERA 411
WP_011736768 333 GTVMVITGPNAGGKTIALKTAGVLVLMALCGMPVPAdGASSTFPLLDDLLVDMGDEQSIEQSLSTFSAHVSRVAAILEQA 412
YP_002247978 332 KKVLVITGPNAGGKTVTIKTIGLLTAMAISGLPIPA-SPSSIIPFVKNIYVDLYHEGSIEEHLSSFALHIITLKKIIEQA 410
YP_003317249 326 ARMMVITGPNTGGKTVALKTVGVCVYLSWLGFPVPC-AEGTVVGNLGELLADIGDEQSIEQNLSTFSGHIKQLRYIMESA 404
WP_083775766 341 FHVLVVTGPNTGGKTVALKTVGMGIILAWCGFPLPA-KEGTVVGNLDNVFADIGDEQSIEQNLSTFSAHLKNIIHILSEA 419
WP_013638390 321 -NGLVITGPNTGGKTVTLKTVGLLSMMAQSGFLIPV-SEGSKLRLFKKWMADIGDEQSIEQSLSTFSAHVKNISEILREA 398
WP_081468084 329 FKQLIITGPNTGGKTVALKTVAVSLYLGWCGFPVPC-KEGTEIGDIDWMLADIGDEQSIEQNLSTFSAHLTRLIDMLQKA 407
WP_014806770 328 FKALVITGPNTGGKTVALKTVGLCVYLAWCGLPIPA-REGSRIGQFSSLEADIGDEQSIEQNLSTFSGHVKRIIDMLAQA 406
WP_066745550 326 FRILVITGPNTGGKTVALKTAGVCIYLGWLGFPIPA-GEGSLLGDIGELFTDIGDEQSIEQSLSTFSAHVTHVSEILNRV 404
WP_111335463 469 GPKSLVLLDELFTGTDPMQGAALAVALLEELARRGSTAAVTTHLENLKTLAIQNQAFANASMGFDVETLEPTYRLTLGIP 548
WP_004512907 412 DDRTVVLLDELGTGTEPVQGAAISCAVLADLQEKGARVIATTHLTDIVGFVHKRDGMVNASMEFDRATLTPLYRLKKGEP 491
WP_011736768 413 GPRSLVLLDELGAGTEPQQGAAIACGVLRELRERGAMVIATTHLSEIIGYVHATEGMVNAGMEYDAETYTPLYRLISGQP 492
YP_002247978 411 DSESLILLDEIGTNTDPEEGSALACAILEELKNREALTFATTHLSKVKIFAATQQNIEIASMLFDEKTMTPLYKLSIGSL 490
YP_003317249 405 KDRSLVLLDELGAGTDPEEGSALGVAILEFFLRRRCLLMATTHYNRIKLFAMTTPGVEAASMEFDSTTLQPTYRLLVGIP 484
WP_083775766 420 TRSSLVLLDELGAGTDPQEGAALGIALIDTLREKKSITLATTHHNPIKSYALTTPHVETASMEFNVETLAPTYHLLMGIP 499
WP_013638390 399 DKDSLVLLDELGAGTDPIEGSTLAIGILKYLKEKNAKVIATTHFTPVKLFAYKDDYYDVASVMFDEETLKPLYKLAYGII 478
WP_081468084 408 NERSLFLLDELGAGTDPQEGAALGIAILERFRSIGSLVIATTHHNSIKRYALSTKGVETASMEFDSETLKPTFRLLMGMP 487
WP_014806770 407 DDRSLFLIDELGAGTDPEEGAALGIAILETFLKKGSLVLATTHHNSIKRYALLTQNVETASVDFDPETLQPKYKLLLGVP 486
WP_066745550 405 TPRSVVMLDELGAGTDPEEGAALGIALLDWLREERALVLATTHHNPIKRFALTTEDIETASVEFDSATLSPTYRILIGIP 484
WP_111335463 549 GSSFALRISRRLGLPQKLIDRAMEVLDgEDHHHVDEVLASLEEQMSELHAERNRLEHARREAEQKKYRFEKKYQSLLEKE 628
WP_004512907 492 GQSHALEIARRYGLPDRVVEFATGMLS-RMETEFHELLAELKDQRRRHEEALAEAERLRRDAEEKARIVRERLAEAEAKR 570
WP_011736768 493 GHSHAIEIARRYGMPDRVISFAREMLG-TASEEFTSLLAELHRKRGELEHGAAQLEREREQVRAIRRELEARSATIEQAR 571
YP_002247978 491 TPSYALEVAQKYGFPENLIRRAYELKG-TQDREIYELIKELEKNKQEYETKLAEIEKIKNIMDSEKNRLEKELVFASENK 569
YP_003317249 485 GSSNAILIAERLKLPREVIQRAREEME-TRSDGTEALLKGLEARRAELEERLREVEALRAHLQERERLYEEKYGRILSDS 563
WP_083775766 500 GRSNAIYIAERYGMPSEVLQKARATLK-EQEISMEEVIADLHERKALLNHEWEKMEEQRQKADLLSKEYSEKMKALEEQR 578
WP_013638390 479 GRSYALEIAKRYGMPEEVIETARSLMT-AEDRLAEDIIAALEKEYRKLTEEKETVERLKEALKKKEEELQKK-------E 550
WP_081468084 488 GKSNALTIARHLGMPEEILSKAEEVLL-ESYYGEERLVDELHDKHMELDQLKKQLESKEADLKRLKDELEREKRNLALEK 566
WP_014806770 487 GKSNALLIAKRLGMPDEVLEIAKRELK-GSDTSMEDLLERLRAKLSALEEKEKELANETANLKAAKRELERQLSGIEERR 565
WP_066745550 485 GRSNALLIAGKLGMRRSIIERAERAIN-GREISMEDLIGELHEKRAALEREANAVEASRKKLAALEKDYEAKIKAIEEKR 563
WP_111335463 629 RTAINADARALKKDLHKARELIREKIKTLQQAGVv---SGKSSLSQKELSEF----QDE---LrgSEEvIDRahertrpa 698
WP_004512907 571 REAVEKAFQEAKEIVRSARREVNAIIEEARKEKS--------REARKKIDEA----EAR---V--EEQ-LQEfhp----- 627
WP_011736768 572 QETREKAWADAREVISTARRRMNELLDEYRRERR----SESIEKLRRVEAEV----TEQ---L--SPRd----------- 627
YP_002247978 570 KKIIEQAKIEAQSMLTKLKKEINFLYEEAKKa-----dRKKLREISQKISDI----SKKf--I--SEe------------ 624
YP_003317249 564 EGIIRETRAKAQGIIKRAEEEAKALLKELRDKSHae-aQRTYQRDRDRLRKL----GQA---V--ED--LGRdv------ 625
WP_083775766 579 EKIIAKAEQQAATVLASAEEESRRMIRDLDEAARsv-vQRNLHGKRENIREK----RKE---L--EQ--KEEkr------ 640
WP_013638390 551 KELKEKSAREIEKFIEELKKKSEEVFKKAKSEKA-----------KQEIRQIvitaKNRakaL--AE------------- 604
WP_081468084 567 GRIVSEAERKALEMIEEAQRLYHEMVKKIGFFNArn-mHKSTEKDRQRMLKM----KKE---L--LERq----------- 625
WP_014806770 566 ERILAEAERRAKKIVKEAQESAKLLLKELSKTHNladaHRTFAKMREQTDKI----LDD---I--EREeATRies----- 631
WP_066745550 564 DALIANADKKALSIVRNAEDSARALIKNMENAQAeseaRRELEKKRSHFQKI----ERSa--I--KR--EEQkt------ 627
WP_111335463 699 kvsPSGyiE-LPADEV-EVGLKIYVRSFNRMGTIVEFDeRSRRVQVQLGVLKAKVDLDDLFyP-SEAQRQahlrgDs-Sg 774
WP_004512907 628 ------eeR-VPLEAI-SEGDTVHVKRLGHDVTVLAVDrKGETLKVRAGTFELVVEAADVA-PpREKGGK-----Kp-Ka 692
WP_011736768 628 ---LAGd-D-QPLGEV-AEGDSVRIRSLGHDGRVLQLLpKQGRARVRAGSMELEVPLSDLV-AplKQTGG-----Ta-T- 693
YP_002247978 625 --------P-KKQEEL-NPGDIVKIRNLNLSGKILIIE--DGRAKIQTDTAQIEAELRELE-KvSfHEEQ-----Es-N- 684
YP_003317249 626 --mEAS--PlPGPQSL-SVGDPVEIRGSAVKGELAQVD--GDHGVVVSGPMRIRVPLKKLV-RsSSPlPVp-------Qs 690
WP_083775766 641 --fIKKm-K-DEKRNL-EIGDAVSIAGTSITGTILALK--GNKAEVQAGAARMDVPLISLT-PtSKKVRD-----AlpE- 706
WP_013638390 605 --------A-KEVREV-KPGNTVKLLKSGRKGKVLEVDkERKVAKVLVGGLKVDVKLSQIE-PvEETVKQ-----E---- 664
WP_081468084 626 --dVHDe-K-MEAEEI-SPGDLVEIIGQSTKGTVEAIE--EGKAVLLCGPIKVEVQLNKLK-LvKKKEEV-----E---- 688
WP_014806770 632 ------ksSiAEGR-IpRVGDKVKILGTNATGIVESVD--NEKATIQSGPIKVDVSLKKIR-ViEESDKK-----Eg-Q- 694
WP_066745550 628 --sVESv-A-ATSHEL-KAGDTVQVIGTSKSATVIEVK--GKKARIQAGIAEIEVPLTKLK-ViTRKSPD-----Ra-P- 692
WP_111335463 775 gKpRgqqgadkGAqApdpaqdgehGLDITi-PQTPDNTVDLRGMRVDGSLEKLDLFLDHAYAKGEVGVHIIHGHGTGALK 853
WP_004512907 693 -Ra-----------Aa--------KIAAPs-RESTPHELNLIGLRVDDALGRLEPFLNHASLEGYGEVRIVHGKGTGALM 751
WP_011736768 694 -RpS----------Gg--------DWRVQa-VEEGERELKLIGLRVEEALALLDPFLSQASLGSFSEVRIIHGLGSGRLR 753
YP_002247978 685 -Kr-------lDIfSvtn----kkAIE-NykEEYPSKKLEIRGMRVDEALPLVERFLNELSFSESNRGIILHGIGKGILR 751
YP_003317249 691 ------------------------RVLVSs-PEKVSSSIMVRGMTLDEAMPIVERYLDQAYRAGYGEVEIIHGRGEGILR 745
WP_083775766 707 --------------Sp--------AMSATk-PQGVPLSLMIRGMTVDEAMPLVEQYLDRAMRAGYLSVEIIHGRGEGILR 763
WP_013638390 665 -Ei--------------------vKVNVKk-PSTFFPELKLLGMRGEEALAAVEQFLDDANLVGIKRVKIVHGYGTGILK 722
WP_081468084 689 -Rt--------AVqGp--------IVKgDfkKVSVPPSIMIRGMTVDEAIPEVELYLDRAFRAGYGEVTIIHGRGEGILR 751
WP_014806770 695 --------------Si--------KINIEr-PQNVPSSIMIRGMRVSEAMPLVETYLDKAFRAGYREVTIIHGRGEGILR 751
WP_066745550 693 -Qa-----------Qv--------QIKVSr-PVGVPSSIMVRGMTIDEALPMVEQYLDQAYCAGYDTVTVIHGRGEGILR 751
WP_111335463 854 RAVRGHLIDSRYVKEFRRGARNEGGDGITVALLA 887
WP_004512907 752 RGVREYLDGHPLVREFRPGEPFEGGEGATVVLLR 785
WP_011736768 754 QAVREHLAHHQLVEEFRPGNAHEGRDGATVVTLR 787
YP_002247978 752 DAIRDYIKDHPAVKSFRKGNPDEGGDAVTVIEMK 785
YP_003317249 746 RAVHDLCRRLPFVESFRLGGPGEGGHGVTIVRFA 779
WP_083775766 764 REVHQFCAHLSYVESYRLGGPGEGGHGVTIVTFK 797
WP_013638390 723 RLIREYLKESPYVKSFRPGKIEEGGDGVTIVELK 756
WP_081468084 752 REVHALCKRLPYVTNFRLGEPSEGGIGVTIVSFR 785
WP_014806770 752 QEVHALCRRLPYVEDFRLGGPGEGGYGVTIVRFV 785
WP_066745550 752 REVQELCKRVPYIAEHNLGGPGEGGYGVTIVKFR 785
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