Conserved Protein Domain Family
Hint

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pfam01079: Hint 
Hint module
This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.
Statistics
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PSSM-Id: 460051
Aligned: 22 rows
Threshold Bit Score: 218.277
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDL86418     187 KAEN-------SVA-AKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAAD-DQGRLLYSDFLTFLDRDE------GAKK 251
XP_003963214 189 KADH-------SVA-VEKGGCFPGWSRVTVAGGFQKSLSSLTPGDRVMALS-ETGQVVFSPVLLFLHRDP------ESRW 253
AAI63355     190 KADH-------SVA-VEKGGCFSASGLVTMADGVQKPMSCLWPGEKVLSVS-GSGEVVFSRVLLFLHLDR------ESRT 254
EEN48116     223 KAES-------DTT-ATQGGCFPAESWVTRDDGNRIRMRDVRPGDKVLSMD-SGGHPVFSEVLTFMDRDS------RGPW 287
NP_001027634 293 KSEE-------SDA-AKYGGCFPGESTVIVPGEGHVPMSSLQPGDQVLAID-KSGAVITDTFLSFMDARSdivsghQAYR 363
P91573       374 YSARgyspnlnGLFgGTGMQCFSGDMEVETEDG-IKMIKDLKIGDKVLSMD--EAFVTYSPVIMFLHKRD------EEIA 444 Caenorhabditis ...
Q94129       326 AAPAgyapmgfAPSgLQLYYCFPGDAMVNVYNGGFKRMDELAVGDWVQALDkNGSQVTFIPVQYWLHRDP------KQVA 399 Caenorhabditis ...
CAP27407     326 AQPAgyfpyfsAPAgLELYYCFPADATVHVYDQGTKRMDELEVGDWVQAFEkNGETVTHVPVQYWIHRDQ------TQKA 399
Q94130       324 AQPVgya--pyAPAgWQLHYCFPADAEVNVYEKGVKRMDELEVGDWVQALH--GKETTYSPVKYWLHRDP------EQEA 393 Caenorhabditis ...
NP_001027635 185 RADN-------SDA-AKYGGCFDGVSEVRNESGSVIPMNKVNVGDRILAVDrTTGKPVFSEVIMFLDKQP------EIGG 250 vase tunicate
EDL86418     252 VFYVIETREPrERLLLTAAHLLFVAPHNDSGPTPGp--------------------SPLFASRVRPGQRVYVva-----e 306
XP_003963214 254 RFLSLQTEDG-RRLAVTPHHLVFSDAHCGPDSSQY---------------------QAQFASRAQTGTCVLV-------- 303
AAI63355     255 SFFIITTENE-KRIALTPNHLIFAAHNLKLHHHDY---------------------ETVFARNVRIGDYILT-------- 304
EEN48116     288 VYYTIHTDDRnITVTATPSHLVFVTESRDLSSPR----------------------IAKFMSDARPGEFLLTp------- 338
NP_001027634 364 QMVEITTENG-FSVTLTRNHLIYVSKPTYDASLLTatsnatqqnnerlglqdftspHSSFAAKVRQGDYIYTlpnshtgp 442
P91573       445 EFNLIETANG-HSIKLTDNHLIYVSDCRTRSDL-----------------------KLVAAKEVKMDDCIHV-------- 492 Caenorhabditis ...
Q94129       400 DFVEFTLDNG-ETFSLTEKHLVFVTQCSVPYSEDEni-----------------naNPVPAERVNIGDCFYIa------h 455 Caenorhabditis ...
CAP27407     400 TFIEFSLDNG-EKFSLTEKHMVYVSQCE-NNNYVEgi-----------------nsNAVPAEKVNVGDCFYVa------h 454
Q94130       394 EFVEFLLENG-ESFTLTEKHLVFATDCQQNVKNLDd-------------------lNPTSTGKINIGECFFMa------q 447 Caenorhabditis ...
NP_001027635 251 SYIEIRSQL--ETIRLTANHMLFIATQTNCSNSFSat------------------kRAVFAGDIFSGQYVYTt------i 304 vase tunicate
EDL86418     307 RGG-DRRLLPAAVHSVTLrEEAAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPF-RLAHA------------- 371
XP_003963214 304 HTA-GGEVHPSRIVSITE-EESVGAYAPLTEAGSVFVDGVLASSYALVEDHRLAHWAFGPV-RLLSS------------- 367
AAI63355     305 TGG-DRGIQPSKVVSVSL-EERMGVYAPLTEHGNLFVDGVLASNYATFQDHGLAHTVFWPF-RVLFVffnkemeedlqrv 381
EEN48116     339 DSD-GGGFRKVKIVSVTM-REEKGAYAPLTVHGTVVVDNVAMSCYALIESQALAHWVFAPF-RLYYQ------------- 402
NP_001027634 443 DTP-SATVRPSRVVSVRTiETASGAYAPLTYSGTIIVGGTAASCYAVIESDVIAHTVVSPF-RYYHW------------- 507
P91573       493 TTD-SNVVIKKKVSKISK-VIETGIYSPLTSTGDIIVNRVLASCHSNLALKSLQQTFFSLYkRTSSV------------- 557 Caenorhabditis ...
Q94129       456 RKK-SQMYQRVKVLDINI-VQKTGIYSPMTSRGHLLVDRIHASCHSETDNYSLQNTFFTNVlRWKSQ------------- 520 Caenorhabditis ...
CAP27407     455 RTN-SKLYQHVKVLDINK-VKKTGIYAPMTSVGHLLVNRIHTSCHSETDNHTLQDTFFANAlHFKNL------------- 519
Q94130       448 PEN-ASKFQKVQILDIQR-VRKTGIYAPMTSLGHLLVNQIHTSCHSEIDHHLLQNSFFKHVlKLKNR------------- 512 Caenorhabditis ...
NP_001027635 305 QARdGFEIQPSRVESVTT-VTGDGLYAPLTAHGTVVVDGIVASCYGVIGSETLAHAAMLPI-RSFPY------------- 369 vase tunicate
EDL86418     372 ------------LLAALAPartdgggggsip-----------------apqsvaeargagPAAGIHWYSQLLYHIGTWLL 422
XP_003963214 368 ------------VSQLLWAepeersdgsktplqphalvrgdrkvcarnstsvrseagprgRTSEVHWYAQLLHRLGWIVL 435
AAI63355     382 avpyicstnqtiLTSVMHSrlssvfkwqda--------------------traemenaflQQKEVYWYARLLHTLGRIFL 441
EEN48116     403 ------------LTSSLWDgpsh----------------------------------dqtLQEGVHWYPSFFYRYGISLV 436
NP_001027634 508 ------------LSLWFNGdskdhrnc--------------------------thvgpvrPTDGISLYSKLLHQIFSKVL 549
P91573       558 ------------FHNLMFFks--------------------------------------sTEEG-----DLPVGVETLTS 582 Caenorhabditis ...
Q94129       521 ------------IRNYFWTve-------------------------------------dsTNED-----NIGYGLNGVMA 546 Caenorhabditis ...
CAP27407     520 ------------LMKFFGTad--------------------------------------sTKEE-----NLGYGIHSLLD 544
Q94130       513 ------------ISKYFWNee--------------------------------------sNTEG-----NIGTSLNFLIE 537 Caenorhabditis ...
NP_001027635 370 ------------LRRTNSD-------------------------------------------VGIHWYAKSLAEIARIVL 394 vase tunicate
EDL86418     423 D 423
XP_003963214 436 N 436
AAI63355     442 D 442
EEN48116     437 E 437
NP_001027634 550 P 550
P91573       583 V 583 Caenorhabditis elegans
Q94129       547 V 547 Caenorhabditis elegans
CAP27407     545 V 545
Q94130       538 I 538 Caenorhabditis elegans
NP_001027635 395 P 395 vase tunicate
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