2RPQ,1U4A,1WM2,1WM3,1WZ0,2AWT,2CKH,2D07,2IO0,2IO1,2IO3,2IYD,2K1F,2MP2,2MP2,2N9E,3UIN,3ZO5,4BKG,4NPN,5D2M,5ELU


Conserved Protein Domain Family
Ubl_SUMO2_3_4

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cd16115: Ubl_SUMO2_3_4 
Click on image for an interactive view with Cn3D
ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins
SUMO (also known as "Smt3" and "sentrin" in other organisms) resembles ubiquitin (Ub) in structure, ligation to other proteins and the mechanism of ligation. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of Ub and the epsilon-amino group of a substrate lysine. SUMOs, like Ub, are covalently conjugated to lysine residues in a wide variety of target proteins in eukaryotic cells and regulate numerous cellular processes, such as transcription, epigenetic gene control, genomic instability, and protein degradation. The mammalian SUMOs have four paralogs, SUMO1 through SUMO4. SUMO2 and SUMO3 are more closely related to each other than they are to SUMO1. SUMO2/3 are capable of forming chains on substrate proteins through internal lysine residues. The basic biology of SUMO4 remains unclear. A M55V polymorphism in SUMO4 has been associated with susceptibility to type I diabetes in some genetic studies.
Statistics
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PSSM-Id: 340532
Aligned: 38 rows
Threshold Bit Score: 130.18
Created: 3-Mar-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:SUMO2-SENP1 interaction site [polypeptide binding site]
Evidence:
  • Structure:2CKH; Homo sapiens SUMO-2 in complex with SENP1, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #                              #  # # #### #  #          #  # ##
2RPQ_A        17 HINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQ 88  human
2CKH_B         3 HINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQ 74  human
2K1F_A        12 HINLKVLGQDNAVVQFKIKKHTPLRKLMNAYCDRAGLSMQVVRFRFDGQPINENDTPTSLEMEEGDTIEVYQ 83  fruit fly
AAX30013      13 HINIKVQGQEGSIIHFKIRKSTPFKKLITAYCDRLGVNQSAVRFFFDGNSVHETDTPGSLEMEENDTVEVFQ 84  Schistosoma mansoni
XP_001748629  68 YINLRVTGSDGADTHFKIKRVTQMKKLMDAYCQRKGLSMQSVRFVFDGTNIGPDDTPTSLEMDEDDSIDVFH 139 Monosiga brevicollis MX1
ACO10543      13 QMTLKVVGQDGQVVHFKIKKNTPLRKLMHAYCDRSNLAVKTIRFVFDGQRISENDTPKVLDMDDGAIIEVFT 84  Caligus rogercresseyi
ADF45342      22 HINLKVTGQDGSVVHFKIKKNTPLRKLMSAYCDRVGLKLASLRFRFDGNPINETDTPTALDMEDGDSIDVFA 93  Azumapecten farreri
CBY38624      10 HINLKVAGQDGSVVQFKIKKHTPLRKLMQAYCDRQGLQLNLVRFRFDGNPVKETDTPENLEMEDEDTIDVFQ 81  Oikopleura dioica
AEG90861      14 HITLRVVGSEGSTVQFKIKRSTPLRKLKKAYCDKQGGAIDTLRFRYDGSNILDEDTPQVLDMEDMDQIEVFQ 85  Japanese sea cucumber
XP_003388063  19 HINLKVTGQDSSVVHFKIKKNTQFKKLMTAYCDRQGYQRNSIRFIFDGTQIQEDQTPIDLDMEDEDTIEVFQ 90  Amphimedon queenslandica

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