Conserved Protein Domain Family
Sds3

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pfam08598: Sds3 
Sds3-like
Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.
Statistics
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PSSM-Id: 430099
Aligned: 59 rows
Threshold Bit Score: 92.806
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004179054            33 LEIKVSKIYNNFINNKDVYYQERLTFLQTQLTTLHQGNNKEYLRKFKDLEEERDLELIRLRLFEEYRINRSRIEFQQDIK 112 
EDK39745               291 AVAELIEIEKAFASLRDKMYHDKLNLLEHELQLCVEGSHPELSKIYYKINAFHQDALRQANSNLSYRLKCIDRETVACRT 370 
XP_004197397           302 AVEELISIETAFASLRDKLYKDKLELLEHELQLCLDGSHPELSKVYHKVNQFHRESMKQANANLTYRLRCIDIETVATRT 381 
XP_002490626           314 ALSSLNELEVDFAKLKDMIYGNQMTKLQYELELCLKGSHPEFVNIVDKINRNFDAKLNRLIMTQKYQLQCIDNQTKATRL 393 
ESW99844               110 ALEEIKNIEIEFALLKDKLYETQMNKLLFELELCNSNKHPDFLNYSNMIENNFQAKVARYVNLQKYKLKCLDNQTRATRV 189 
WGS:AAWC:PGTG_16224.3  673 ALEAMVKIEIMFAQVRDRLYAERLSDVYRETAAVQHGSHPELNEYYQLLERKRDARLSLAHKIFNLKEIELNKKREAATN 752 
CCF49854               461 AMEALTKIEIGFAMLRDRLYVERLQEISKEGQMILDGTHPELLHLTKAIEMRRQRRTQLVEMRFEQQEQQYQRVAKAEEF 540 
XP_007855938           447 ALEVLASIELRFALVREKLYVEKMQSLAWEESLVEDGTHPELIYLQSELSRRKDKRLELAARKRTYEFSHVSRKRKLEED 526 
1_pfamImport             1 CLDEMTTIEKQFMDIRDQLYRERHTQIMQKLDEVNAGTAPEYLQQLLALETSKQVRMQVSDIYQRLRLNALKTNLEAETQ 80  
XP_015785800            52 HINEMLDLERQFLALKEQLYMERIKQIEKKLEEVKAGNAQEYLGPVDDLHHQMEIRMKVAGILKEFKFKNVNIQYEAEKQ 131 
XP_004179054           113 KAKDEHEKLIKLCKEKLYENIDYKIKKLQEERILLDFANAHSYamdystLS-FNnsnnyngsknsngkfnsnnnmynnei 191 
EDK39745               371 AVHQNFLKQVYDSKSEMITNTTSMWYKINRERNQLDQ------------LVpDYsysasggafvs--------------- 423 
XP_004197397           382 SIHQNFLKKLMDTRNDMISDVTYMWYKINKERNQMDQ------------VVpDFnfs----------------------- 426 
XP_002490626           394 QLHQQYMKDAQDLKLRSISKTTSKWYEINKERRHLDNVIL---------GVpDYyq------------------------ 440 
ESW99844               190 AIHQQFIKCCQDLKNEEITNITSNWYEINKERRALDNVTL---------NLpDYyq------------------------ 236 
WGS:AAWC:PGTG_16224.3  753 SVWTRWYEAKTELHDSMIVETQKQMKQLEREKCQPDLRYNVEVqllprpIIpRHnpgrrsrkrarlemdetneellaiql 832 
CCF49854               541 AAWSIWRSSCASLRRDMMDEFSRKRRRLDREKRTLDA------------------------------------------- 577 
XP_007855938           527 ATWSWWKLAKDELQTDMIAETNRKKRRLERDRRQMER------------------------------------------- 563 
1_pfamImport            81 ANAQHLKNEKQILMGRIEFDLSEKMHRLEEDRENVDLSN----------------------------------------- 119 
XP_015785800           132 AVDQNFQSEKNLARDQIRRELEERIRRLEEDRNSVDLWGDSLY------------------------------------- 174 
XP_004179054           192 dngfKNTRSHTS---------STwetssnneylagaainnannnlangnlsngrasreSGNESyNTTd------TGFDNR 256 
EDK39745               424 -----------------------------------------------ndgnddgstalPQSVl----------yELVSQR 446 
XP_004197397           427 --aiPKIPNYTIpaqseedpaASsysssl------------------------tkkiaKQNTl----------vELVQHR 470 
XP_002490626           441 --fnPDLASAAKknqt------------------------------------------------------alvqELANQR 464 
ESW99844               237 --ynGDITAANVnsqs-------------------------------------------------------ainRLVVQR 259 
WGS:AAWC:PGTG_16224.3  833 htaiAKRATVNLstltseeswAD-----------------------------------LSVMKpQSRnahldpvNILCAP 877 
CCF49854               578 --------------------------------------------------------------PrPARkhqifetELVRNP 595 
XP_007855938           564 --------------------------------------------------------------PvPIRhipgmpmEILTAP 581 
1_pfamImport           120 --------------------------------------------------------------------------QLWGDG 125 
XP_015785800           175 ----------------------------------------------------------NPKKKrRIGnngstyyEVGPSR 196 
XP_004179054           257 RSLRrrrvgantggqtsnieesnygyssatgagskkrktgksnnnsqdtnhttNDAELfQSLAD---------------- 320 
EDK39745               447 NAIN-------------------------------------------------------HQLGI---------------- 455 
XP_004197397           471 NNVN-------------------------------------------------------QQLGI---------------- 479 
XP_002490626           465 RNFQ-------------------------------------------------------QELGV---------------- 473 
ESW99844               260 NALY-------------------------------------------------------HELSS---------------- 268 
WGS:AAWC:PGTG_16224.3  878 QSMA-------------------------------------------------------TYFRDdpyepttepskkllps 902 
CCF49854               596 DRLH-------------------------------------------------IPLQSsAQIMDdaengrp--------- 617 
XP_007855938           582 PTLR--------------------------------------------------------QLIDnppfgsrefqqprlkn 605 
1_pfamImport           126 RDLDpif------------------------------------------------------------------------- 132 
XP_015785800           197 DQLHlld------------------------------------------------------------------------- 203 
XP_004179054           321 ---------------------RPDLQRLl------FGIEYV----------------NAnkDKkkGRNsQRYS------- 350 
EDK39745               456 ---------------------LNGLVE--------FSGIPAa-------------------------------------v 469 
XP_004197397           480 ---------------------LNGLVQ--------FHGFPCa-------------------------------------i 493 
XP_002490626           474 ---------------------LTALQQ--------NYRFPSsl------------------------------------- 487 
ESW99844               269 ---------------------LKGIEKY-------TGGFPSsl------------------------------------- 283 
WGS:AAWC:PGTG_16224.3  903 lgsgdkldnhhnlardpaiigAEKLIALnpklihsRASYPSqvqslsspssklhsrrLNngLDglTNIhTSSS------- 975 
CCF49854               618 --------------grkgaakRKAMASReidagdqFVAYPD--------------------------------------- 644 
XP_007855938           606 khrnrevhtnvnassgkrdmgTNSAGALv------PLAYPE--------------------------------------- 640 
1_pfamImport           133 -----------------------------------------------------------rkKKkkEEVyPSFSfggvkrk 153 
XP_015785800           204 ------------------------------------------------------------------------------rr 205 
XP_004179054           351 NKSAPT----------LKSLNTEEVVDDI 369 
EDK39745               470 GSSLGDeqqv--pellLRKASEEEIADDL 496 
XP_004197397           494 ASGLNDddqipssellLKSATNEEILEDL 522 
XP_002490626           488 --------------nhLTAAREDEIESDL 502 
ESW99844               284 --------------ndLKSCTGEEVQQDL 298 
WGS:AAWC:PGTG_16224.3  976 SRTVRN----------SNRLTSEQIEPDl 994 
CCF49854               645 ----------------LKGLAEADVMTDI 657 
XP_007855938           641 ----------------LPTLSSADVGNDL 653 
1_pfamImport           154 KKPVTVtgp-----yiVYMLRDCDIMEDW 177 
XP_015785800           206 RKPVPVsgp-----yiVYMLKDSEIIDDW 229 
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