6YOV,1AOI,1EQZ,2HUE,2PYO,3A6N,3KWQ,3W99,4UUZ,2YFW,4XYI,1ID3,4KUD,2L5A,2LY8


Conserved Protein Domain Family
HFD_H4
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cd22912: HFD_H4 
histone-fold domain found in histone H4 and similar proteins
Histone H4 is a core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called the histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Links
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Statistics
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PSSM-Id: 467037
Aligned: 104 rows
Threshold Bit Score: 74.5636
Created: 31-Aug-2020
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:6YOV; Homo sapiens Histone H4 interacts at DNA, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              # #  ##       #####                                  ###               
6YOV_B     24 VLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAK-----RKTVTAMDVVYALKRQGR 98  Homo sapiens
QBK85672   22 ILRDNIQGITKPALQRLCHRAGIKRISDDMYEILRDSIKTYMERILHKTVIFTEREQ-----RRTVKVKDLEAALNMTGI 96  Marseillevirus LCM...
QBK86551   18 VFSDNIQGLTKPAFERIARKAGVKSMSGLCKEELRGVVLSKMRPLIEDAVIFTKNRN-----ASTISVNDVLEAIKNQKQ 92  Marseillevirus LCM...
KOO26764   93 ILRDNIQGLTKSCFLRLCARAGVINISETVFEELRAITRDFLMKHMRHAITMTEHAR-----RRTVIASDALVEWVEGGC 167 Chrysochromulina t...
SCO54527   23 ALRDSVYAITKPNIKRLARRGGVKRISVDVYNEIRHALQERLKTANSPIIGCCETYVih-rdGKAVTKKDVHQSLEFLGC 101 Fusarium fujikuroi
THC97895   24 ITRPTIRSLTATYISRLARRGGVIRMKQEIYDEVRTVVRSRLEVVLKQVVLILDSSTthkrnRKVVTSRDVSPYHAPPRK 103 Aspergillus tanneri
XP_657721 466 ALGSEVDPNARDVTSRLARRGGVYRIKNEIYDEIRIVLKERLAEVCLVMESGTIPSSe----RKLVTTRDVVYALKRMLT 541 Aspergillus nidula...
QBK91785   16 VTEDPIKGFKDVQIRNLAYRASAQRIEKDTYGKVREIIGDRIDELLRKILVFTTHTG-----RKTVTLEDLQGALEAEGT 90  Pithovirus LCPAC304
QBK85747  359 FTENQLEKIGTNGIERLARRGGVKRTSADMYPVVRSFMYSLVSMVLYKCVHIIAYRK-----IMTIGVFDLEVAFESFGV 433 Marseillevirus LCM...
QBK86758   58 EEAGRVMLITRPPIKRILKRAGCTRISRDVFEVVYQQLYDYTEKILLSTAVVTDHAP-----RSTIQVSDLNSGFKAHGQ 132 Marseillevirus LCM...

Feature 1         
6YOV_B     99 TLYG 102 Homo sapiens
QBK85672   97 YLAA 100 Marseillevirus LCMAC101
QBK86551   93 NFAF 96  Marseillevirus LCMAC102
KOO26764  168 ECRG 171 Chrysochromulina tobinii
SCO54527  102 PVWG 105 Fusarium fujikuroi
THC97895  104 YRYG 107 Aspergillus tanneri
XP_657721 542 THPF 545 Aspergillus nidulans FGSC A4
QBK91785   91 PLMA 94  Pithovirus LCPAC304
QBK85747  434 NFTI 437 Marseillevirus LCMAC101
QBK86758  133 LLAL 136 Marseillevirus LCMAC103

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