6S7T


Conserved Protein Domain Family
Ribophorin_II

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pfam05817: Ribophorin_II 
Oligosaccharyltransferase subunit Ribophorin II
This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesized polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them.
Statistics
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PSSM-Id: 461749
Aligned: 36 rows
Threshold Bit Score: 387.405
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6S7T_F         9 VFLLALTIIASTWALTPTHY----LTKHDVERLKASLD----RPF------TNLE------SAFYSIVGLSSLGAQ---- 64  human
XP_003537048  14 FLLLLLPFSFSFS-----------ISHSHRSAAINLFA----ATP------TSLE------DAYEALRVFQILGIEeknt 66 
Q93Z16         7 VRFLVLILAVAICGAASvf---qpISDSHRSAALDVFVpv-dGSY------KSLE------EAYEALKTLEILGIDkk-s 69  thale cress
CBI37135      74 flVLVLILTISIHKAAS-------ILDSHQPVALELFSpv-hGSF------GSLE------ESYDALQTFQILGIEkk-p 132
EEF32552       7 gGFLVLLVVALICSVSSSASisypISDSHRSAALELFTpi-gGSF------GSLE------EAYEALRTFEVLGIDkk-p 72 
XP_002307654   6 ggFLVLIAAALIYSSALASYifqpISDLHRSAALELFNpl-gGSF------PSVE------ETYEELRTFEVLGIDkr-s 71 
Q5N7W3        11 ATLLLLVIAAVAVAPLASAVr--pVSDAHRSAAAELFAaspdGSF------GDLE------TTYEAVRTFQILGVEkd-k 75  Japanese rice
EFC49240      10 rtlLAVVLVILCSASVFALTiqngLTQQDKTNIQSVLE-------------KDFKgisnkkDLFYSASTLLKISNGdi-i 75 
EFA81631      13 VLMVSLTIGMISAAKTAPSSlsstLTASNIKSLSSMIEs--hRPSngglydNDLK------ETFYAVGALTRLSQP---- 80 
XP_009397601   9 vgFAALICAALLSISAAASIr--pISDAHRSAALELFVpi-dGSF------PSLE------ETYEALRTFQILGLGkt-s 72  wild Malaysian ...
6S7T_F        65 -VPDAKkaCty---iRSNLD-PSNVDSLFYAAQASQALSgCEISI--SNETKDLLLAAV-SE--DSSV-TQIYHAVAALS 133 human
XP_003537048  67 pVNEDT--CqkvvesLASSS---PLKDLFYALKVNAILK-CNVNGnvFKDIASRLKATVh----DASAlLDIYYSIGGLV 136
Q93Z16        70 dLSSKT--CenvvkvLQSSS--STLKDAFYALNVNGILK-CKIGEagPKDIVSQLQAGVk----DAKLlLDFYYSVRGLV 140 thale cress
CBI37135     133 dISDTT--CtlvsktLGSSS--SSLKDLFYALKVNGILK-CDIDEevFEGIKSRLQSVSn----DASSlLDFYYSIGSLA 203
EEF32552      73 dISVPA--ChsiletLGSSS--AVSKDIFYALKVNGILK-CEVNEdvLEGIVSNLQTAVs----SASSlLDFYHSIGSLV 143
XP_002307654  72 dISTAA--CqsvseiLGSSS--STLKDLFYALKVNGILK-CDIKEdvFEGVASRLQAAVs----GASAlLDFYYSVGGLA 142
Q5N7W3        76 gLIGKA--CkfaaekLASSS-SSPAKDLFHAARISGVLK-CSVDSgvYDDVATRLKAVIk----DTNSlLELYYSVGGLL 147 Japanese rice
EFC49240      76 qSAQNQ--C------VKTISnVEGPEALYNLIASNAALK-CSP-LesYTAVQSALAKYIdESsdKTSA-ENIYSIARSIL 144
EFA81631      81 -IVKDSelCkqvrglIEQRS--NDIESVFYGVSILSEIK-C---LaaNPVPLSLIENAVqKSleNGNI-NELAAAVNTVF 152
XP_009397601  73 dISNAT--CpvvldkLRSPT--SSPKEFFNALRLNGILG-CEIGSqtFENVASHLHALIk----DADSlMDLYYSVISLL 143 wild Malaysian ...
6S7T_F       134 GF----GLPLASQ---------EALSALTARLSKE-------ETVLATVQALQTA------------SHLsqQA--DLRS 179 human
XP_003537048 137 VI----KDQDSNVdvll-advdGVFQSIKVLSQSDgrwryssDNPESSTYAAGLAleslaglislasSEFdqSKvnVVKN 211
Q93Z16       141 LA----KEQFPGThisl-gdaeAIFRSIKSLSQSDgrwryssNNPESSTFAAGLAyetlagvislapSEFdpSLiqSVKT 215 thale cress
CBI37135     204 LI----KEQASKVdvll-tdadGIFQSIKALSQSDgrwryssNNPESSTYAAGVAfealarvvalasPEIdqSRisTLGN 278
EEF32552     144 LI----KDQSSKdvsf--edaeGVFRSIKALSQSDgrwrysfNNPESSTFAAGLAlealagvisvssSEIdqSLiaTTKN 217
XP_002307654 143 LI----KGQTTKDdlyl-adaeGVFQSIKALSQSDgrwrynsNNPESSTLAAGLAlealagivslssSKIdqSLirTTKN 217
Q5N7W3       148 SI----KEQ--GHnvvl-pdadNTFHAIKALSQSDgrwrydtNSAESSTFAAGIAlealsavisladSEVdsSMiaVVKN 220 Japanese rice
EFC49240     145 LT----KSKINVAdlkisklyeLVVKQLTSSIKQDcn----dACLKSVGFLMEAAqi---------lQSIqkSDvaSLNK 207
EFA81631     153 LLldakSISYDVAnl------eSAANRLVSLMDADgefklesGSDDASIINNGVAyftmarlshrlkSVAgiSN--LVDK 224
XP_009397601 144 HI----KGQ--GVsavl-sdaeGVFHSIKALSQSDgrwrydsNNAESSTYAAGIAlealaavvsladAEVdqSKigIVKH 216 wild Malaysian ...
6S7T_F       180 IVEEIEDLVARLDE----LGGVYL---QFEE----GLETTALFVAATYKLMDHVGT-EPSIKEDQVIQLMNAIFSKK-NF 246 human
XP_003537048 212 GIVKLFDGIEKYEDgtfyFDEKYVgghEQRG----SLSTTSSVVRGVTAFAAVTSG-KINLPGDKILGLAKFFLGIG-IP 285
Q93Z16       216 GILKLSDSIQKYDDgtfyFDEKSVda--sQG----PISTTASVIRGLTSFAASEST-GLNLPGDKIVGLAKFFLGVG-IP 287 thale cress
CBI37135     279 DIVKLFDSIEKYDDgafyFDEKIVdarEHHG----PLSTTASVVRGLTAFADVTSG-SLNIPGDKILGLAKFFLSVG-IP 352
EEF32552     218 DILKLFDSIEKYDDgafyFDEKHa--qENQG----PLSTTSSVVRGLTAFADVTSG-NLNLPSEKFVGLAKFLLGIG-IP 289
XP_002307654 218 DILKLFDSIEKYDDgafyFDEKLVgahEHQG----ALSTTSSVVRGLTAFAAVTSG-SLNLPSGKILGLAKFFLAIG-IP 291
Q5N7W3       221 DIVKLFDTIKSYDDgtfyFDEKHVdaaEYKG----PITTSASVVRGVTSFAAVASG-KLNIPGEKILGLAKFFLGIG-LP 294 Japanese rice
EFC49240     208 AISALTSVTKKA------ISSN-------------NVETVAIFARGLNKLATIVDV-KSKVSKEDFVALINSLVSKKdSS 267
EFA81631     225 VVSKLPSVVSSASD-------------SASGfvwhDLATTSSIFRGIVALTSQSEKvANTITPLQIQRIGDYLLRFK-ST 290
XP_009397601 217 DIEKLFDSIKSYDDgtlyFDEKHVdgsEYKG----PLTTTASVVRGVTAFAAV-AG-KLNIPGDKMLGLAKFFLSIG-VP 289 wild Malaysian ...
6S7T_F       247 ESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSA--SDTHEQAILRLQVTNVLSQPLT-QAT-VKLEHA-KSVASRATVLQ 321 human
XP_003537048 286 GDAKDFFNQVESLAFLESNRISIPLILSLPETA--YSLTKKGQLKVKVNTVLGSAAPp-LT-VKLVRAfSTGAKDSAIID 361
Q93Z16       288 GDAKDFFNQIDALACLEDNKFSVPLILSLPSTV--ISLTKKEPLKVKVSTVLGSKAPa-LS-VKLTQAlSSKSVDSSVIN 363 thale cress
CBI37135     353 GDAKDFFNQVYSLACLESNRVSIPLILSLPATV--LSLTKNDQLKVRVNTVLGSNAPp-LT-VKLLQAfSSSSKNAFIIE 428
EEF32552     290 GDAKDLFNQVDSLAYLESNRISIPLILSLPATV--LSLTKKDTLKVKVNTVLGSNAPpSLT-VNLVRVfSSGSKDTSIIE 366
XP_002307654 292 GDAKDLFNQVDSLAFLESNTVSIPLILSLPATV--LSLTKKDALKVKVNTVLGSNAPp-LT-VNLLRVfRSGSKDTLLTE 367
Q5N7W3       295 GSAKDCFNQIESLSFLENNRVFVPLVLSLPSKV--FSLTSKDQLKVEVTTVFGSAAPp-LR-VNLVQV-LGSDSKVITTE 369 Japanese rice
EFC49240     268 KTLSEIYHLIEGVQSFTK-PIYEPIV------VvsELKDEKGAISLQISNILGAPL---SEkVTLQSVyKGSNSDDSILP 337
EFA81631     291 ASLQDAFNLVIGLKSCAKNSIGQPLSVVLNPTTfdSSASGKKLVTVQIHDIFDHPV---ATqVTVAKVaLATARNTAVIS 367
XP_009397601 290 GSTKDLFNQIDALSCLESNrISIPLILSLPATV--LSLTSKDQLKVEVTTVFGSAAPp-LT-VILVQA-SSYDKDTPVLE 364 wild Malaysian ...
6S7T_F       322 KTSFTpvg--dvFELNFMNVKFSsGYYDFLVEV-----EGDNRYIA-NTVELRVKI-STEVGI----------TNVDLST 382 human
XP_003537048 362 SKELRydqesgfHVLDALPKNVDvGTYVFVFEIvlhdfGSEKVYATgGQIHVPIYV-TGIIEV----------GNAEITV 430
Q93Z16       364 NQELKfdadsatYFLDSFPKNFDiGKYTFVFKIvldesAHEKVYITeAQTKVPIAA-TGAISI----------ENAEIAV 432 thale cress
CBI37135     429 NQELKfdpenavHFLDALPENVDvGNYVFVFEIllhdpEHEKIYATgSRTRVPIII-TGVIKV----------DTAEIVI 497
EEF32552     367 NQELKydtensvYFLDALPKGVDvGNYIFVFETvfhdaAHEKVYTTgGQTQVPIFV-TGVIKVtmlxxldcrnSKKYIDM 445
XP_002307654 368 SQELKfdpanavYTLDALPKSVDvGKYTFVFETvlhdsDHKNLYATgGQTRIPIFV-TGIIEV----------DTAEIAV 436
Q5N7W3       370 TKELQfdldnnvHYLDIAPLKIDvGKYSLVFEIslqeqEHETIYATgGTNTEAIFV-TGLIKV----------DKAEIGI 438 Japanese rice
EFC49240     338 KGPVKlda--ngVEYQIKGVKLDsGIFNFDITV------------GkEAVTRSLKTaAADLKI----------RDFQLDV 393
EFA81631     368 NKELSd------NQLDVSELKl--GSYVADIKI-----NPSEDNFHpFTVTRTITV-SGAAAV----------RDFKLIV 423
XP_009397601 365 NQELQfdtenniHYLDILPLKIDvGKYTLEFEIslhdpENLNIYATgGRANALAFL-TGTIKV----------DKAQIGV 433 wild Malaysian ...
6S7T_F       383 VDKDQSIAPKTTRVtyPAKAKGTFI--ADSHQNFALFFQLVDVnTGAELTPHQTFVRLH-----NQKTGQEVVFVAEPDN 455 human
XP_003537048 431 LDSDLGSAETQKKLdlAGNDAVSLS--ANHLQKLRFSFQLTTP-HGHVFKPHQAFFKLR-----H-ETKVEHIFVVGNTG 501
Q93Z16       433 LDSDIGSVESQKKLdlTKDGAVSLS--ANHLQKLRLSFQLTTP-LGNAFKPHQAFFKLK-----H-ESQVEHIFLVKTSG 503 thale cress
CBI37135     498 LDSDLGSVETKRKLdlAGENDVSLS--ANHLQKLRLSFQLATP-LGHAFKPHQAFLKLK-----H-ETKVEHVFVVGSSG 568
EEF32552     446 LDA-----SSSDMLdlAGENLVSLS--ANHLQKLRLSFQLTTP-LGHAFKPHQAILKLR-----H-ETKVEHIFVVANSG 511
XP_002307654 437 LDSDLGSIETKKKIdlAGDNTVSLS--ANHLQKLRLSFQLSTP-LGHAFKPHQAILKLT-----H-ETKVEHIFLMGSSG 507
Q5N7W3       439 SDNDAGTVESVQKIdlQKDTSVSLS--ANHLQKLRLSFQLSTP-LGKTFKPHQVFLKLK-----HDESKVEHLFVVPGSA 510 Japanese rice
EFC49240     394 GK------FSRSNVayPKTLEEKLTidVDSNNRIRVNFALAGVa------PHQVFLRIG-------NCKNEAIFNIKQQH 454
EFA81631     424 ADNKEALANSKQIFtvESQNQLSLE--LPAAKTARIFFRVVS--GDQPFVAQQVGVRFVskvnpSIETVVQAVFSVD--- 496
XP_009397601 434 FDSDAESAATMQKLdlSQDNRISLA--ANHLQRMRLTFQLVTP-LGHNFKPHQVFLKLR-----H-ESKVEHIFALESSA 504 wild Malaysian ...
6S7T_F       456 KNVYKFELDT-SERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEA--PSTV----LSQNLFTPKQEIQH 528 human
XP_003537048 502 -KKFEKVLDF-LGLVEKLFYLSGKYEIELTVGDAVMENSFLRLLGHVELDLPEAPEkaPRPPpppvDPYSRYGPKAEITH 579
Q93Z16       504 -KKSELVLDF-LGLVEKLYYLSGKYEIQLTIGDASMENSLLSNIGHIELDLPERPEkaTRPPlqstEPYSRYGPKAEISH 581 thale cress
CBI37135     569 -KDFAIVLDF-LGLVEKFFYLSGRYDIQLTVGDAVMENSFLQALGHVELDLPEPPEkaPRPPpqpvDSYLRYGPKAEIAH 646
EEF32552     512 -KKFEIVLDL-LGLVERFFYLSGRYTIQLTVGDAVMENSFLKVIGHVDLDLPEAPEnaPRPPpqpvEPYLRYGPKAEITH 589
XP_002307654 508 -KEFEIILDF-LGLVEKFFYLSGRYNVQLTVGDAVMENSFLKAVGHIDLDLPEAPEkaPQPPaqplDPNLIYGPKAEIAH 585
Q5N7W3       511 -RQFKIVLDF-LGLVEKFYYLSGRYDLELAVGDAAMENSFLRALGHIELDLPEAPEkaPKPPaqavDPFSKFGPKKEISH 588 Japanese rice
EFC49240     455 QPNYNLDLGLdRVVGPALKYESGEYKVQIFIGDATLSTPIHWTVATVVINFSKQIEktE--------EELLYQPRELITH 526
EFA81631     497 --SYSYVINS-RDLGKLLNFQSGAYAVDVLVGDSSIA-PLNWQVGQLTLNFDQAATgtT--------RYPVHQP---IDH 561
XP_009397601 505 -RQFKIILDF-LGLVEKFYYLSGRYEIDLAIGDAAMENSFLRVLGYIDLDLPEPPEkaSRPPpqpvDPYSRFGPKPEISH 582 wild Malaysian ...
6S7T_F       529 LFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFA----PSTIIFHLGHAAMLGLMYVYWTQLNMFQTLK 604 human
XP_003537048 580 IFRSPEKRPHQELSLAFLGLILLPFIGFLVGLLRLGVNLKNFPGStvpaTFGILFHVGIAAVLLLYVLFWLKLDLFTTLK 659
Q93Z16       582 IFRIPEKLPAKQLSLVFLGVIVLPFIGFLIGLTRLGVNIKSFPSStgsaISALLFHCGIGAVLLLYVLFWLKLDLFTTLK 661 thale cress
CBI37135     647 IFRAPEKLPPEQLSLAFLSLTILPLIVFLIGLLRLGVNLKNFPTSvvpaTFAILFHLGLAAVLLLYVLFWWKLDLFTTLK 726
EEF32552     590 IFRAPEKLPPKELSLTFLGLTLLPFIGFLVGLLRLGVNLKNFPSSavsaTFAFLFHFGIAAVLFLYVLFWLKLDLFTTMK 669
XP_002307654 586 IFRVPEKLPPKELSLTFLGLTLLPFLGFLLGLLRLGVNLKNFPSSsvpaMFAALFHLGIAAVLLLYVLFWLKLDLFTTLK 665
Q5N7W3       589 IFRSPEKRPPKELSFAFTGLTLLPIVGFLIGLMRLGVNLKNFPSLpapaAFASLFHAGIGAVLLLYVLFWIKLDLFTTLK 668 Japanese rice
EFC49240     527 IFRAPEKRAGSEIASLFSLVVFAPLAIFLIGLITVRFNFGGCPSGla-gLLAPVFVGLLGVLVGILAMYFISWDIFVTMK 605
EFA81631     562 RFRVPESRPPQVVSQTFTLLVLAPFVIFLIGLPVLGANLNRFPGGmg-fIYTVAFIGCAALVGLLIVTYWFSLTMVVTLR 640
XP_009397601 583 IFRSPEKRPPKELSFSFLALTIVPLVGFLIGLLRLGVNFKGFPSSsvpaLFSILFHAGIAAVLLLYGLFWLKLDLFMTLK 662 wild Malaysian ...
6S7T_F       605 YLAILGSVTFLAGNRMLAQQ 624 human
XP_003537048 660 AFGLLGAILMFVGHRILSHL 679
Q93Z16       662 ALSLLGVFLLFVGHRTLSQL 681 thale cress
CBI37135     727 ILGLLGVFLLFVGHRLLSHL 746
EEF32552     670 TLGFLGVFLMFVGHRILSHL 689
XP_002307654 666 ALGFLGAFLMFVGHRILSHL 685
Q5N7W3       669 YLSFLGVFLVFVGHRALSYL 688 Japanese rice
EFC49240     606 YLGLAGIAITLVGAKVLSGV 625
EFA81631     641 YLGLLLIPTVFFGQKTLSHF 660
XP_009397601 663 ALGLLGVFLIFVGHRTLSHL 682 wild Malaysian banana
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