Conserved Protein Domain Family
bHLH_TS_ASCL5
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cd19747: bHLH_TS_ASCL5 
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and similar proteins
ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that belongs to AS-C (achaete, scute, lethal of scute, and asense) family.
Links
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Statistics
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PSSM-Id: 381590
Aligned: 5 rows
Threshold Bit Score: 130.894
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #   # ### #    #                 ####                  
Q7RTU5       151 PFEPAFIQKRNERERQRVKCVNEGYARLRGHLPGalaEKRLSKVETLRAAIRYIKYLQELL 211 human
KYO33194      65 PFEPAFIQKRNERERRRVKCVNEGYARLRGHLPGtmsEKRLSKVETLRAAIRYIKYLQDVL 125 American alligator
KKF14105      76 PYEPAFIQKRNERERQRVRCVNQGYAKLRDHLPGqsaDKRLSKVETLRAAIRYIKYLQGLV 136 large yellow croaker
XP_014351917  79 PFEPAFIQKRNERERQRVKCVNEGYARLRDHLPGamsEKRLSKVETLRAAIKYIKYLQDLL 139 coelacanth
XP_007899822  84 PFEPAFIQKRNERERQRVKCVNEGYTRLRDHLPSavaEKRLSKVETLRAAIGYIKYLQDLL 144 elephant shark

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