Conserved Protein Domain Family
AF-4

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pfam05110: AF-4 
AF-4 proto-oncoprotein N-terminal region
This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Statistics
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PSSM-Id: 461550
Aligned: 26 rows
Threshold Bit Score: 374.461
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014068153   20 YEQDRNALKKREWERRTQEVQQDEDLFSSGFNLFGEPYKteapslstlggtnnlnkTNKGDALANRVQNTLGNYDEMKEL 99  
4_pfamImport    1 YNEERKLLRLRAWEQRNQGTSQAKD--QENMPLFGEPYK-----------------TNKGDELSNLIQRMLGSYEDVNH- 60  
XP_011945625    2 NREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKv----------------TSKEDKLSSRIQSMLGNYDEMKDF 65  
OCT87770        2 NREERNLLRLKERERRNQEIQQGEEAFPSDSPLFAEPYKv----------------TSKEDKLSNRIQSMLGNYDEMNEM 65  
XP_004076172    9 NREDRNVLRMKERERRNQEIQQGGEAFPANSPLFPEPYKv----------------VSKEDKLSSRIQSMLGNYDEMKEP 72  
XP_015204977    9 NREDRNALRLKERERRNQEIHQGGEAFPANSPLFPEPYKv----------------SSKEDKLSSRIQSMLGNYDEMKEL 72  
PKK32498       31 YEPDRNVLRRKEWERRNQEAQQEDGAFNTSYSLFSEPYK-----------------TNKGDELSNRIQNTLGNYDEMKDL 93  
XP_016282184   71 YDQDRNALKRKEWERRSQEVQQDEDLFASGFSLFGEPYK-----------------TNKGDALASRVQNTLGNYDEMKDL 133 
KFO61033        2 YEQDRSALKRKEWERRNQEVQQDEDLFASGFNLFGEPYK-----------------TNKGDALANRVQNTLGNYDEMKDL 64  
XP_011936965   18 YEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYK-----------------TNKGDALANRVQNTLGNYDEMKDL 80  
XP_014068153  100 ---LTSHSNQsHLVGIPKNFVPq---TPgPMEKQDQ-PSFLTKGGQrGSNRVGTGN-HTTSMPPPPSSSSLTSssllhgH 171 
4_pfamImport   61 ---------P-----NPAAMEPfripTYaSFSQSDQgQTSLDGQAG---PPFHTQAsGSQSQKAPGGSGVP--------S 115 
XP_011945625   66 ---IGDRSIP-KLVAIPKPTVPp---S--ADEKSNP-NFFEQRH-G----GSHQSS-KWTPVGPAPSTS----------- 118 
OCT87770       66 nerVNDRSLP-KLVGIPKSAVPp---TA-PDDKTGQ-GYFGDQRHS----SSHQSG-KWTPVGSAPSTS----------S 124 
XP_004076172   73 ---IGD-TLP-KLGGKPSNSSS----S--SEEKLAA-PLFGGDQRG------SESS-KWTPVGPAPGGS----------- 122 
XP_015204977   73 ---IGDKSLQ-KYMGLPQPAVP----ST-PEEKPNQ-TFFAEQQRG---SGSSHSS-KWTPVGPAASTSs---------S 129 
PKK32498       94 ---LTDRSNQsHLVGVPKPGVPq---T--SLPKPDE-HHIADSRPM-PPPPISSTT-SS----TPAALP----------A 148 
XP_016282184  134 ---LTNHSNQsQLVGIPKNSIP----QT-PTEKNEQ-SFFPDQRNR-MIAPHQ--G-SSQSVPLLSSVT-SSSs-----H 194 
KFO61033       65 ---LTNHSNQsHLVGIPKNSVP----QT-PIDKNEQ-NFFPEPR-NrMIPSHQISGnTSTSMPPPSSLSSNSTll--hsH 132 
XP_011936965   81 ---LTNHSNQnHLVGIPKNSVPq---N--PINKNEP-SFFPEQKNR-IIPPHQDNThPSAPMPPPSVVILNSTl-----I 145 
XP_014068153  172 QSSKkSW-SSDWSRGA-HCST-QGVGGQGVGGQGvHGvgglgvqgvggpSCSRGKHSFTHEQQQQpqRHEELLisQGEVV 248 
4_pfamImport  116 QSSRtSGaASSPDHQG-NSSP-FSNASLNPSQLS-YA------------VPCHQRSEDRLRDh------------ARLAQ 168 
XP_011945625  119 QSQKrSS-GLQSGHSS-QRTSaGSSSGTNSSGQR-HD---------------RESYNSSGSSSRKk-GQHGSEhsKSRSS 179 
OCT87770      125 QSQKrSS----SSSGG-HSRS-SNSSSQRHNKDS-YS------------S-SRKK------------GQHSSEhsKSRSI 172 
XP_004076172  123 TSQKrSG--LQGGHGS-QRSS-GGSSSSSQRGER-EK------------KSSKHSGGSEHSK----------------SH 169 
XP_015204977  130 QSQKrSG--LQSSHGSgQRTT-GSGGGGGSSSQR-HE---------------RDYSSSSNSG-GN--SQKKSKhgSDHS- 186 
PKK32498      149 QQSK-St-TMGWQKAG-HNAA-SDG------QQR-AS------------KHGHRSLESHKGD----------FklANQKS 195 
XP_016282184  195 QNIRkPR--ADWPRAG-HCST-ITQAS-----QS-TG------------LPNRMKQSNPHDQPQG--RYEDLFncQSDQH 250 
KFO61033      133 QSSRkSR--TDWSRSG-HNSS-GAQPSQSSGQQS-R-----------------TKHSSSHDQSQG--RYEDLYncQSEQH 188 
XP_011936965  146 HSNRkSK--PEWSRDS-HNPS-TVLASQASGQP--------------------NKMQTLTQDQSQa-KLEDFFvyPAEQP 200 
XP_014068153  249 D---HRGDSSSSPS-SSSTSTLSRRHGGGQQQAAKAPSAA--EHGsy------kDSNTHV-KSPLEQEPGSHGASS--Pv 313 
4_pfamImport  169 E----------ARShSPPAKPLSLQCSGDLGTTGANTKEAcdH-HpritpsecpGFGDASaLVPRDSTKDSCLPQA---- 233 
XP_011945625  180 S--------PGk---PQAVSSLSSSHSRSHG-------ND--HHS---------KEHQRS-KSPRDPDANWDSPSR---- 225 
OCT87770      173 --------SPGKQS------ALNSSHSRSH-------GSD--HHS---------KERPHS-KSPRDPDANWDSPSLa--- 216 
XP_004076172  170 T------SSPAKSS-------LSSSGSQSRGSLSA---EQ--HHC---------KERYRS-KSPLDREANWDSPSRv--- 218 
XP_015204977  187 ---------KSHTS-SPAKGSLSSSHSRSH-------GGD--HHG---------KERHRS-KSPRDRDANWDSPSRv--- 234 
PKK32498      196 S---LEKLKRYA---SSPTSSSSSSNAAQQSSLR-NTLGD--NVN---------RVQQPA-KLNCSSEGGGQSQER---- 252 
XP_016282184  251 KnggMEDASMSTSS----------SNSRRLSHSKA-SGGD--HFY---------KESIPC-PSPIDFEFLANGPISplSs 307 
KFO61033      189 KsggTEEANPMATS----------SHSRRHTHAKSA-PGE--HTY---------KENSHS-KSPTELEFVGHGPGSplPs 245 
XP_011936965  201 QigeVEESNPSA-----------------KEDSNPKSSVE--DAF---------KEIFQS-NSPEKSEFAVQAPGSplVa 251 
XP_014068153  314 aSTSLLPSGLSTPTFPQGLHVKPSAvQQQKPTAYVRPMDGQDQMPLDSPELKPPlEvvdVGYSNPAF-GS---TITS--- 386 
4_pfamImport  234 ----SKGHSLPSQTFPSLLSKQPSVvMTQKPTAYVRPMDGQDQVVTDSPELKPS-P--------EPY-GPlpeLI----- 294 
XP_011945625  226 --VPFSSGQHSNQSFPPSLMSKSNS-MLQKPTAYVRPMDGQ-----ESMEPKLS-S---EHYSSQSHgNSmteLKPS--- 290 
OCT87770      217 --PSFSSGQHSSQAFPPSLMSKSNS-MLQKPTAYVRPMDGL-----ESMEPKLS-S---EHYSSQSHgNSmseLKSN--- 281 
XP_004076172  219 -HTSFPSGQHSSQSFPSSLMPKTSS-MQQKPTAYVRPMDGQ-----ETAEPKSSqA---ESYSGQPHsGPmgeMKSN--- 285 
XP_015204977  235 -HAFSSNGQHPGQAFPPSLMSKPSS-MQQKPTAYVRPMDGQ-----ESLEPKTP-S---ENYSSQSHsSSmgeMKPS--- 300 
PKK32498      253 --PAKHSGGHCVQNFPPSLASKP------------RPMDGQDQAPDESPKLKLP-A---E--TTKSY-RGvpsNKPDsar 311 
XP_016282184  308 tSLLSSASSLSVQNFPQGLYCKTSM-VQQKPTAYVRPMDGQEQLPDFSPALKPL-LeieSGYSSQTF-GTlleGKPSatt 384 
KFO61033      246 tSLLTANNGLSTQNFPPGLHCKNSM-VQQKPTAYVRPMDGQDQVPNDSPELKPPiEi-eSGYGNQSF-GTlleGKVNtps 322 
XP_011936965  252 sSLLAPSSGLSVQNFPPGLYCKTSM-GQQKPTAYVRPMDGQDQAPDISPTLKPSiEf-eNSFGNLSF-GTlldGKPSaas 328 
XP_014068153  387 SKSKL-PKLTLT-QTGEV------------GLSSDSSCVEEILREMTHSWPPPLTAIHTPGKAEQTRFPIPSKESQHIPS 452 
4_pfamImport  295 TKPLMeTDRETLpPYLEFiklklrertfteMRPNEAQCVEAILREMTCSWPPILTALNTPNSDEPSKSPSQPRGAEHVSS 374 
XP_011945625  291 SKAHL-TKLKIPsQPLDA------------SASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNF 357 
OCT87770      282 SKAHL-TKLKIPsQPVDA------------SASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKDAQQSSF 348 
XP_004076172  286 GKASL-TKLKIPsQPVEG--------------SGDANSVAEILKEMTQSWPPPLTAIHTPCKTEPSKFPFPTKEAHPFPS 350 
XP_015204977  301 SKASL-SKLKIPsQPLDA------------SMSGDANCVDEILKEMTQSWPPPLTAIHTPCKTEPSKFPFPAKDNQHSNF 367 
PKK32498      312 TKSKI-AKFSIP-KQEED------------GGTGDNSCIEEILREMTHSWPPPLSAIHTPGKAEQSKFPFPNKESQQGST 377 
XP_016282184  385 AKTKL-PKLTIP-QPSEI------------NLSNDPNCVEEILR-----------------------------DLQLSTS 421 
KFO61033      323 SKNKV-PKLNIP-PVSEV------------ALPNDSSCVEEILREMTHSWPPPLTAIHTPGKAEQTKFSIPSKDSQHLTS 388 
XP_011936965  329 SKTKL-PKFTIL-QTSEV------------SLPSDPSCVEEILREMTHSWPTPLTSMHTAGHSEQNTFSIPGQESQHLTP 394 
XP_014068153  453 GCAGQKRCNVPVNKPATKSVPQk--SMLEDDLKISSDEEDTEQ--------------QGAEKPKPRSTPLSIPVATSRT- 515 
4_pfamImport  375 HPGQRNRLNFSSQTVVQNQQLGf-tSAFRSDLSFLFSFSFHLA--------------VLPEKCDTSAADASQQVHRRSSc 439 
XP_011945625  358 GTGEQKRYN-PS-KTSNGHQSK---SMLKDDLKLSSSEDSDGE--------------QDCDKTMPRSTPGSNSEPSHHN- 417 
OCT87770      349 SSCEQKRYN-PSTKTANGHPTK---SSLKEDLKLSSSEDSDGD--------------LECGKTMPTNTPGSSEPSHN-N- 408 
XP_004076172  351 GHKRG----SSSKSSSSHQTKDg--SMLKEDLMISSSEDSDGE--------------QE-------AKNASRNTSASNN- 402 
XP_015204977  368 NKRYS-SEKTSSSSHQPKTCDGdqaNMLEDDLKLSSSEDSDGE--------------QEPAKPGSRITPSTSEPSQDT-- 430 
PKK32498      378 GHSNTRKSDVEPRSPEKSATHT---SMLEDDLKLSSDEEENDQ--------------QAAQRSALRVLSDSLVVPPSNTr 440 
XP_016282184  422 AYSVQKWSDPEIKAATKPPVPQk--SMLEDDLKISSDEDEIE---------------QDIEKAKTMDIPSNPTVPPAP-- 482 
KFO61033      389 GYNVQ-KWSDPAGKVAT--------KMLEDDLKLSSDEDDNEQvntsnikhhsgtanVAAEKTKLRNIPVNLPVPAAHA- 458 
XP_011936965  395 GFTLQ-KWNDPTTRAST--------KMLEDDLKLSSDEDDLEPvktlttqctatelyQAVEKAKPRNNPVNPPLATPQ-- 463 
XP_014068153  516 -SDPGH-SSGASASSSESESSseSDSDSESSSSDSECNRASRTATPEPEPPSTN-KWQLDKWLN 576 
4_pfamImport  440 sFKVPHsRGLESTSSSDSESSsrSDSDSES-----AAEEPPKCPRSGPAA--KHvDWQLGNWIR 496 
XP_011945625  418 -SEGADnSRDDSSSHSGSESSsgSDSESESSSSDSEANEPSQSASPEPEPPPTN-KWQLDNWLN 479 
OCT87770      409 -SEGAEnSRDDSSSHSGSESSsgSDSESESSSSDSEANEPSRSASPEPEPPPSN-RWQLDNWLN 470 
XP_004076172  403 -SEAAEqSRDDSSSHSGSESSsgSDSESESSTSDSEANEPPQPASPDPQG--SN-KWQLENWIK 462 
XP_015204977  431 -NEGADhSRDDSSSHSGSESSsgSDSESESSSSDSEANEPPRVASPEPEPPTAN-KWQLDNWLQ 492 
PKK32498      441 -ASGLSsKGSSSSSSSESETSseSDSESESSSSESDGSKPSHYSSPEPEPPSSN-KWQLDKWLN 502 
XP_016282184  483 -EPVVIpSSGGSES-SSSDSSseSDSDSESSSSDSEGNEESRSNTPEPEPPSTN-KWQLDKWLN 543 
KFO61033      459 -TGLAHsS-GGSGSSSESESSseSDSDSESSSSDSECNEESRSATPEPEPPSTN-KWQLDKWLN 519 
XP_011936965  464 -PPPAVqTSGGSGSSSESESSseSDSDTESSTTDSESNEAPRVATPEPEPPSTN-KWQLDKWLN 525 
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