Conserved Protein Domain Family
Fez1

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pfam06818: Fez1 
Fez1
This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.
Statistics
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PSSM-Id: 462015
Aligned: 36 rows
Threshold Bit Score: 160.163
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011601607 532 TKWEVCQKSGEISLLKQQLKEIQSELSQKAGDIVVLKAQLREARSEMQASQARFQEAQAALRTRTLE------------- 598
XP_016153653 424 TKWEVCQKAGEISLLKQQLKDSQADVSQKLNEIVGLRSQLKEGKNFLREKEEQILTLKDSYSSKSVN------------- 490
OCA47638     417 TKWEVCQKAGEISLLKQQLKDCQADLSQKLNEIVGLRTQLKEAKAFLREKEEQIASIKDSYSSKSVS------------- 483
EDL80205     468 TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQAS------------- 534
XP_021336943 268 TQWEVCQKSGEISLLKQQLRDSQAEVTQKLSEIFHLKTQLHETRNQMRSKDSQIDSLQTAV------------------- 328
XP_002603684 318 TKWEMCQKSGEISLLKQQLKEAKSELSLKTNDVIASRGTIKDIKTELSEKDSQVTALQDKVSEKNAE------------- 384
6_pfamImport   1 SEWERQQKYGELSMLKSQLKDIQAESAQRGSEIVALRTRNRELQALVARRDAEAVDLNEKLNDRNLE------------- 67 
XP_001948001 295 TEWGLCQKSGELAHVKSQLKDTQNELTTKGHEVIALKSEIRDLLQKLESKERRIDEIEGRRPERLDSdnggdgnccddql 374
EEZ98911     308 TEWGLCQKTGEISLLKSQLKDYQNEQTAKCQELLQLRTEHRDFREQLDLREAEISELRHQSEEKDAE------------- 374
OWR54544     125 TEWSLCQRAGEIALLKTQLKEAQNEQTAKGHEYLTLKSDCRQLREALDKKDKEILRLRAESEEKEKS------------- 191
XP_011601607 599 ------------LEVCENELQRR------------KSEAELLREKLGRVEEELTRL----RDALSNHGVLSVSGSgtlkg 650
XP_016153653 491 ------------LEICEGELQRK------------MSEVQVLREKLNHCELEVSGL----KRTLASMAPPAGPFGgelge 542
OCA47638     484 ------------LEICENEMQRK------------QSEAQQMKEKLSQCEQEISSL----KEALASLGQNPYTIElnekl 535
EDL80205     535 ------------LELSEGELPPA------------C-------------------L----KPALTPVDLVEPQEAla--- 564
XP_021336943 329 ------------------QGARR------------KCTMPAFED-----------T----RSDMDTg------------- 350
XP_002603684 385 ------------ILHYQDEVAKQ------------QCELDNLSDTLRKREDELMDL----KDSYRQVK--EDLSNvrael 434
6_pfamImport  68 ------------IGELEQRLSEAsspagtwhrspgSISPQSLRNPSGTFSEPNSGNwhddRNYLSSSSPPg--------- 126
XP_001948001 375 aadklcslvgrlNEQVENELSKSnklls--ecystEDLHSLLPKKDTEADSPLERF----RE------------------ 430
EEZ98911     375 ------------IKLLKEQLARL------------GNKSPTIDD----LKEEIREL----REELSDMSLSEYGSV----- 417
OWR54544     192 ------------MKKLQAEVERLnndlmnsvtdltKTKESNKKE-IEKLKTEVKEL----RQELSDVSLSGYEGIecgrt 254
XP_011601607 651 qcmglsiqqgravggrggpspcvyrdgeehhlvwgGESDEAKAQRQN-------------Ae------TVLALRQQVDRL 711
XP_016153653 543 k----------------------------lrdplaCESDEAKMQRQSe-------------------dSVNSLRRELERL 575
OCA47638     536 ------------------------------rdtlaCESDEAKMKRQN-------------Ed------SVISLKKDIERL 566
EDL80205     565 ----------------------------------sCESDEAKMRRQAgvaaaaslvsvdgEvdaggegGTRALRREVGRL 610
XP_021336943 351 --------------------------------------------------------------------ETGGSSATEERL 362
XP_002603684 435 dnk-------------------------ikeeqliSQCDEVKERRKNk------------Er-----dLIESLKVEVQRL 472
6_pfamImport 127 --------------------------------------------------------------------ALTSLKR--DEL 136
XP_001948001 431 ------------------------------------------------------------------------LERHTAKL 438
EEZ98911     418 -----------------------------------EPGRSq---------------------------RISQEDLEIECS 435
OWR54544     255 mrgi-----------------------ydvcktneYHWTSs---------------------------DSALEDAEVQRL 284
XP_011601607 712 KA-----------------ELLYERRTSEEHLSHFEEERRVWQEEKEKVIRYQKQLQQNYIQMYRRNRDLERVMR 769
XP_016153653 576 QT-----------------ELKLERQQREQQVMDFEEERRTWQEEKEKVIKYQKQLQLNYVEMYQKNQLLEHKVN 633
OCA47638     567 QL-----------------ELTVEKQQRDQQVVDFEEERHTWQEEKEKVIKYQKQLQLNYVEMYQKNQQLEQRMA 624
EDL80205     611 QA-----------------ELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLR 668
XP_021336943 363 RA-----------------ELLLERRQNEAQTSAFESERKTWQNEKEKVIRYQKELQASYLEMYHQNEALERELA 420
XP_002603684 473 RN-----------------ELKTVHQRHDAQLMEFERERAIWQEEKEKVIHYQKQLQLNYVQMFRKTKNLEKEVQ 530
6_pfamImport 137 IK-----------------RLYEAEARCNEQEKFFNIERRQWADDKSRVIRYQKQLQANYVQTYKRCGALEREVK 194
XP_001948001 439 IR-----------------VLNEERKN-------WDQERLKWFQEKEKVLCYQRQLQMNYVQMFRRTQAFEAQIE 489
EEZ98911     436 CS-----------------SLAKLKQEIASKTKDFENERVVWAQEKEKVLRYQRQLQMNYVQMYRRTRALEAEVE 493
OWR54544     285 NGelpdscsepcpagaivdRLKCEIQNKEQQ---FNNERRKWSDEKDKVLRYQKQLQMNYVQMFKRSRTLEAEID 356
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