Conserved Protein Domain Family
Herpes_ori_bp

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pfam02399: Herpes_ori_bp 
Origin of replication binding protein
This Pfam family represents the herpesvirus origin of replication binding protein, probably involved in DNA replication.
Statistics
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PSSM-Id: 280546
Aligned: 5 rows
Threshold Bit Score: 1059.05
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9E6Q7   3 DYASSASLSRMLYGEDLIDWIIKN--RP-GITTERQSDGPVTFPSPLYPRTRNVLIVRAPMGSGKTTALMNWLQCILCNS 79  Marek's disease herpe...
P10193  26 QYTSSVSLARMLYGGDLAEWVPRV--HP-KTTIERQQHGPVTFPNASAPTARCVTVVRAPMGSGKTTALIRWLREAIHSP 102 Human alphaherpesviru...
P09299  12 vYASSTQLARALYGGDLVSWIKHT--HP-GISLELQLDVPVKLIKPGMSQTRPVTVVRAPMGSGKTTALLEWLQHAL-KA 87  Human herpesvirus 3 s...
Q6UDH3  18 SFSPSVMIARKLYGCDLCERLLTNprMA-GMSLDRQHGHPITFPLPI--RTKPVLVARAPMGSGKTTALIDWLTAFLDSE 94  Psittacid herpesvirus...
P52378   3 NRFQNDTLFSEWFGQSLSDVR-----FPdNVTVYSQADSAVSF----ENVRQPIKLVRAAMGSGKTTALIHFLKQV--PR 71  Human herpesvirus 6 (...
Q9E6Q7  80 NMSVLIVSCRRSFTNTLSEKINRAGMSGFCTYLSSSDYIMRGREFSRLLVQIESLHRVDSKLLDNYDIVILDEIMSTIGQ 159 Marek's disease herpe...
P10193 103 DTSVLVVSCRRSFTQTLATRFAESGLVDFVTYFSSTNYIMNDRPFHRLIVQVESLHRVGPNLLNNYDVLVLDEVMSTLGQ 182 Human alphaherpesviru...
P09299  88 DISVLVVSCRRSFTQTLIQRFNDAGLSGFVTYLTSETYIMG---FKRLIVQLESLHRVSSEAIDSYDVLILDEVMSVIGQ 164 Human herpesvirus 3 s...
Q6UDH3  95 DKSAVIVSCRRSFTNSLSRRFQRDGLTGFTTYLDSDQYVLTEAAHRRLLVQLESLQRISDSLLDRYDVLVVDEVMSIVAQ 174 Psittacid herpesvirus...
P52378  72 ELSVLLISCRKTFAAEILHRFTLNGLKDFELYCDITERQINN---RKVIVQIESLHRLTEN----YDVLILDEIMSIIKQ 144 Human herpesvirus 6 (...
Q9E6Q7 160 LFSPTMKHLCQVDNILTSLLRYRPKIVAMDATINTQLIDMLAIMRGEENIHVIVGEYAASGFSRRSCTILRSLGTNILLS 239 Marek's disease herpe...
P10193 183 LYSPTMQQLGRVDALMLRLLRICPRIIAMDATANAQLVDFLCGLRGEKNVHVVVGEYAMPGFSARRCLFLPRLGTELLQA 262 Human alphaherpesviru...
P09299 165 LYSPTMRRLSAVDSLLYRLLNRCSQIIAMDATVNSQFIDLISGLRGDENIHTIVCTYAGVGFSGRTCTILRDMGIDTLVR 244 Human herpesvirus 3 s...
Q6UDH3 175 FFSPTMRRLRLVDSMFTSLLRRCRHVIAMDATVNATLVELLAELRGAENVHVVVSDFVSRGFANRECVVMSSLGAALPAS 254 Psittacid herpesvirus...
P52378 145 FYSKTMTKTKEVDCKFLSLIKNSSHVIAMDATLTRHVVEFFAAFKPDTQIALIRNTFVSAMFSNRIAYFCDTFFGKEFS- 223 Human herpesvirus 6 (...
Q9E6Q7 240 VMNefkqlp-----shtqpiFKQSTGVNGSLDIS-LHDRT-----FFSELTRRLEGGLNICLFSSTISFSEIVARFCLAY 308 Marek's disease herpe...
P10193 263 ALR-----------------PPGPPSGPSPDASPeARGAT-----FFGELEARLGGGDNICIFSSTVSFAEIVARFCRQF 320 Human alphaherpesviru...
P09299 245 VIK-------------------RSPEHEDVRTIH-QLRGT-----FFDELALRLQCGHNICIFSSTLSFSELVAQFCAIF 299 Human herpesvirus 3 s...
Q6UDH3 255 MVRyappagdesreasasqpPPHDSSNEPCAPEItDADIEstegsFFHELHVRLLQGENVCVFSSTLAFSRIVAFFCAEV 334 Psittacid herpesvirus...
P52378 224 ---------------------------------------------FFARLEDKLRWDKKLCLFCSTVLAAEYMYDLIRSR 258 Human herpesvirus 6 (...
Q9E6Q7 309 --TDSVLVLNSTRNTPiDINSWSNYRVVIYTTVVTVGLSFNDSHFHSMFAYIKPTINGPEMVSVYQSLGRIRSLRLNEVL 386 Marek's disease herpe...
P10193 321 --TDRVLLLHSLTPLG-DVTTWGQYRVVIYTTVVTVGLSFDPLHFDGMFAYVKPMNYGPDMVSVYQSLGRVRTLRKGELL 397 Human alphaherpesviru...
P09299 300 --TDSILILNSTRPLC-NVNEWKHFRVLVYTTVVTVGLSFDMAHFHSMFAYIKPMSYGPDMVSVYQSLGRVRLLLLNEVL 376 Human herpesvirus 3 s...
Q6UDH3 335 lsPDAVLLLNSTSPPV-DTSDWSRYKVVVYTTVVTVGLSFDDSHFHTMFAFVKPSIHGPDMMAVYQAMGRVRSLIRDRLF 413 Psittacid herpesvirus...
P52378 259 fpLKKVLLLTSKQGKCsSIESWIRYDVVIYTSVVTVGLSFEPVYFSSLFVYIQLAKGGPDMVSVFQSIGRVRRVIDEDIY 338 Human herpesvirus 6 (...
Q9E6Q7 387 IYIDASGAGSEPVFTPMLLNHVIANGGGWPTRFSQVTNMLCHNFRRDCIPTF---RAADALYIFPRFKYKHLFERCTLNN 463 Marek's disease herpe...
P10193 398 IYMDGSGARSEPVFTPMLLNHVVSSCGQWPAQFSQVTNLLCRRFKGRCDASAcdtSLGRGSRIYNKFRYKHYFERCTLAC 477 Human alphaherpesviru...
P09299 377 MYVDGSRTRCGPLFSPMLLNFTIANKFQWFPTHTQITNKLCCAFRQRCANAF----TRSNTHLFSRFKYKHLFERCSLWS 452 Human herpesvirus 3 s...
Q6UDH3 414 MYMDVSSANEGPTFTPMLLNAEIGSATAWPPEILIPANTMCLRFKDRCSSAL----LDHHRALFSRFKTKHYLERSTLTS 489 Psittacid herpesvirus...
P52378 339 IYMNPVLIRSYDPLAPI----AIPPCSDWSVAEQSIISESCIDFRGKCSGAH---KYNFCSVLKSLFRYRHYIEKTTITS 411 Human herpesvirus 6 (...
Q9E6Q7 464 VSDSINILHALLESNLIHVRFDGCDL--QLNA---EAFCDFLVILRADSITAQRDMKTLRk---------------NATC 523 Marek's disease herpe...
P10193 478 LSDSLNILHMLLTLNCIRVRFWGHDD--TLTP---KDFCLFLRGVHFDALRAQRDLRELR----------------CRDP 536 Human alphaherpesviru...
P09299 453 LADSINILQTLLASNQILVVLDGMGPitDVSP---VQFCAFIHDLRHSANAVASCMRSLRq--------------dNDSC 515 Human herpesvirus 3 s...
Q6UDH3 490 ANDSFSLLHTLLANNKIAVRMRGDRPdaPASAilvEDFGRFLSRLRTDAFSNRRFLRRITyaieeaasamrervalRNPT 569 Psittacid herpesvirus...
P52378 412 LSDSLFLLCSLLCENSIKVDIVGNGF--PMRK---EVFLSFLQILVEECHFIEKKIT-LPgddmtfqeiissretiMNGD 485 Human herpesvirus 6 (...
Q9E6Q7 524 PLPVEVDVIDSD---AVACFVQKY--LRPTVLA--NDLTELLTKLAE-PITREQFINITMLE---AC---------RATP 583 Marek's disease herpe...
P10193 537 EASLPAQAAETE---EVGLFVEKY--LRSDVAP--AEIVALMRNLNS-LMGRTRFIYLALLE---AC---------LRVP 596 Human alphaherpesviru...
P09299 516 LTDFGPSGFMAD---NITAFMEKY--LMESINT--EEQIKVFKALAC-PIEQPRLVNTAILG---AC---------IRIP 575 Human herpesvirus 3 s...
Q6UDH3 570 AEETVMMLAENQ---AARSCMERFfgLRGAVDDygEPIIALMKDMGDvPLVAARLVNAAVIEagcACsagewyvvdLAAE 646 Psittacid herpesvirus...
P52378 486 FYENGDQLLHKDyitDMGKFRATF--LSPGVDI--FIASDIVYDLKN-ESKRYVFVNVWLQK---------------CVS 545 Human herpesvirus 6 (...
Q9E6Q7 584 AALYSEAVFCRIYDYYASGNIP---------IIG-PSGTLDTTILTCDFNTSGRWDLYRVCCKWAELLGINPLEGPNA-D 652 Marek's disease herpe...
P10193 597 MATRSSAIFRRIYDHYATGVIP---------TIN-VTGELELVALPPTLNVTPVWELLCLCSTMAARLHWDSAAGGSGrT 666 Human alphaherpesviru...
P09299 576 EALEAFDVFQKIYTHYASGWFP---------VLD-KTGEFSIATITTAPNLTTHWELFRRCAYIAKTLKWNPSTEGCVtQ 645 Human herpesvirus 3 s...
Q6UDH3 647 HASHGSSEFDKWMNYYLDE--P---------LVSlKRGRPEEVQIPIQPGIRGRTALLRACVNVARQIGWRPTTWNDDaE 715 Psittacid herpesvirus...
P52378 546 AGVESTEIERVFCERIKCYMLPksflcdeyfVLGdISGVYEWGMLI---------DLAFLAEMIRKDLKLKSCTDTTT-D 615 Human herpesvirus 6 (...
Q9E6Q7 653 IDPTKLLHVMKDDYDI-YARSVLEIARCYLIDAQTALKRPVRATKCALSGIQNSHh--sQPSTQSH---AVSLFKVTWEI 726 Marek's disease herpe...
P10193 667 FGPDDVLDLLTPHYDR-YMQLVFELGHCNVTDGLLLSEEAVKRVADALSGCPPRG----SVSETDH---AVALFKIIWGE 738 Human alphaherpesviru...
P09299 646 VLDTDINTLFNQHGDS-LAQLIFEVMRCNVTDAKIILNRPVWRTTGFLDGCHNQCfr-pIPTKHEY---NIALFRLIWEQ 720 Human herpesvirus 3 s...
Q6UDH3 716 LEAADVERAMATAIEAgLGKFALEYMRLNFTEPSWLT-GPIRNLQRFLGARKRHAahgiGPSEQRKespEICIFRTLWAE 794 Psittacid herpesvirus...
P52378 616 ISEDDLLLCAARRSSD-----ILQIMQLVFTVHVQFFQKYSLQTLQLFNKLRGMRivtgVFSIEKF---SISILRLFFKC 687 Human herpesvirus 6 (...
Q9E6Q7 727 LFGLRLTKSTTTFPGRTKVKNLRKAEIEALLDGAGIDRTSCKTHKDLYTLLMKSKSLFRN-MRYDIRRPKWYDLLRSRLD 805 Marek's disease herpe...
P10193 739 LFGVQMAKSTQTFPGAGRVKNLTKQTIVGLLDAHHIDHSACRTHRQLYALLMAHKREFAG-ARFKLRVPAWGRCLRTHSS 817 Human alphaherpesviru...
P09299 721 LFGARVTKSTQTFPGSTRVKNLKKKDLETLLDSINVDRSACRTYRQLYNLLMSQRHSFSQ-QRYKITAPAWARHVYFQAH 799 Human herpesvirus 3 s...
Q6UDH3 795 LFGVRILKSQRTFPGTTRVKNLRKEHLKALLDRIEVRYPESSTHKQLYGLLRENQYRFSNsPKLLLRTPDWMRQLSGNR- 873 Psittacid herpesvirus...
P52378 688 AFNMTLSASRPRYIPGKAYRNLTKNDMENMLDNWEISRTNLKTCKELRKALTEASRARRKqTIYKLQGSDISLSVS---- 763 Human herpesvirus 6 (...
Q9E6Q7 806 Ke-LGIYHDLVdLESVLAEIPSALWPRVEG 834 Marek's disease herpesvirus type 1 strain MD5
P10193 818 S--ANPNADII-LEAALSELPTEAWPMMQG 844 Human alphaherpesvirus 1 strain 17
P09299 800 QmhLAPHAEAM-LQLALSELSPGSWPRING 828 Human herpesvirus 3 strain Dumas
Q6UDH3 874 -------------------------PQAEQ 878 Psittacid herpesvirus 1 Amazon parrot/1997
P52378 764 -------------EVGVFGQHASPGVCVSS 780 Human herpesvirus 6 (strain Uganda-1102)
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