4IB4,5TVN


Conserved Protein Domain Family
7tmA_5-HT2B

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cd15306: 7tmA_5-HT2B 
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serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors
The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 341347
Aligned: 6 rows
Threshold Bit Score: 471.239
Created: 2-Dec-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4IB4: Human 5-HT2B receptor binds ergotamine, a precursor of the hallucinogen lysergic acid diethylamide, contacts 4A.
  • Structure:5TVN: Human 5-HT2B receptor binds Lysergic acid diethylamide (LSD), contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                  #  
4IB4_A     30 HWAALLILMVIIPTIGGNTLVILAVSLEKKlqyaTNYFLMSLAVADLLVGLFVMPIALLTIMfeamWPLPlvlCPAWLFL 109
P41595     55 HWAALLILMVIIPTIGGNTLVILAVSLEKKlqyaTNYFLMSLAVADLLVGLFVMPIALLTIMfeamWPLPlvlCPAWLFL 134 human
CAD71264   25 CWLALLTLMVIVPTIGGNILVIMAISLEKKlqnaTNYFLMSLAVADLLVGIFVMPVALINILfnqvWQLPqcvCAIWLFL 104 African clawed frog
AEV42168   40 RWAALLILLVIIPTIGGNILVILAVSLEKKlqyaTNYFLTSLAVADLLVGLFVMPIALLIILfdnaWPFPtalCPIWLFL 119 chicken
Q8UUG8     25 NWAALLIVMVIIPTIGGNILVILAVWLEKKlqnaTNFFLMSLAVADLLVGLLVMPIALITILydsdWPLPeplCPIWLFL 104 green pufferfish
5TVN_A     15 HWAALLILMVIIPTIGGNTLVILAVSLEKKlqyaTNYFLMSLAVADLLVGLFVMPIALLTIMfeamWPLPlvlCPAWLFL 94 
Feature 1     ##  ##                                                                       #  
4IB4_A    110 DVLFSTASIWHLCAISVDRYIAIKKPiqANQYNsRATAFIKITVVWLISIGIAIPVPIKGietdv-----dnpnnITCVL 184
P41595    135 DVLFSTASIMHLCAISVDRYIAIKKPiqANQYNsRATAFIKITVVWLISIGIAIPVPIKGietdv-----dnpnnITCVL 209 human
CAD71264  105 DVLFSTASIMHLCAISLDRYIAIKKPiqASQYNsRGKTLIKITVVWVISAGIAFPIPIKGlldpnt----tfsasYTCVI 180 African clawed frog
AEV42168  120 DVLFSTASIMHLCAISLDRYIAIKKPiqASQYNsWATTIIKIIIVWLISIGIAIPVPIRGiedgn-----gnstnITCLL 194 chicken
Q8UUG8    105 DVLFSTASIMHLCAISLDRYIAIKKPiqHSQYKsRAKVMLKIALVWLISICIAIPIPIKGlrnyphpnnitftsnHTCVL 184 green pufferfish
5TVN_A     95 DVLFSTASIWHLCAISVDRYIAIKKPiqANQYNsRATAFIKITVVWLISIGIAIPVPIKGietdv-----dnpnnITCVL 169
Feature 1            ##  #   #                                                                
4IB4_A    185 tkerFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKkaadlednwetlndnlkviekadnaaqvkdaltkmraaaldaq 264
P41595    210 tkerFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKkaylvknkppqrltwltvstvfqrdetpcsspek--------- 280 human
CAD71264  181 qvepFKYFIIYGSMAAFFVPFGIMVVIYFLTIHLLRKkayliknkppqrltwstvstvfqrdatpgsspek--------- 251 African clawed frog
AEV42168  195 tpdrFHDFILYGSVAAFFIPLAIMIVTYFLTIQVLRKkaylinkppqrftwstvstvfqrdatpacspe----------- 263 chicken
Q8UUG8    185 ktdtFQEFIIFGSLVAFFIPLTIMMIIYFLTVRVLRKkvyllrskvtqrfsypiistvfqreqaanppqpeqpds----- 259 green pufferfish
5TVN_A    170 tkerFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKkaadlednwetlndnlkviekadnaaqvkdaltkmraaaldaq 249
Feature 1                                                                                     
4IB4_A    265 katppkledks-pdspemkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylQTISNEQRASKVLG 343
P41595    281 ---------------------------------vamldgsrkdkalpnsgdetlmrrtstigkksvQTISNEQRASKVLG 327 human
CAD71264  252 ---------------------------------iamiegarkdgtlsitgeelpirrlssvgkksmQTITNEQRASKVLG 298 African clawed frog
AEV42168  264 -----------------------------------kvamlngsrkdktptndmpicrtstigrksmQTITNEQRASKVLG 308 chicken
Q8UUG8    260 ----------------------------tgnslariqektdtdgmssptgdeksfrrlstmgkksmQTLTNEQRASKVLG 311 green pufferfish
5TVN_A    250 katppkledkspdspemkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylvQTISNEQRASKVLG 329
Feature 1              #  ##  #  #             #  ##  #   #                            
4IB4_A    344 IVFFLFLLMWCPFFITNITLvlc--dsCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNktFRDAFGRYITCN 414
P41595    328 IVFFLFLLMWCPFFITNITLvlc--dsCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNktFRDAFGRYITCN 398 human
CAD71264  299 IVFFLFVFMWCPFFLTNVASvlcgedqCDEDVIKMLMDIFVWVGYISSGVNPLVYTLFNktFRDAFRRYIKCD 371 African clawed frog
AEV42168  309 IVFFLFLLMWCPFFITNISSvlc--nsCNKEVFQKLMEIFVWIGYVSSGVNPLVYTLFNktFREAFSRYITCN 379 chicken
Q8UUG8    312 IVFLLFVVMWCPFFITNITSalc--gpCDANIIGRLMEIFSWVGYVSSGINPLVYTLFNktFRQAFTRYITCN 382 green pufferfish
5TVN_A    330 IVFFLFLLMWCPFFITNITLvlc--dsCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNktFRDAFGRYITCN 400

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