1NK1,1B2I,1A0H,1KRN,1CEA,2PF2,1URK


Conserved Protein Domain Family
KR

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cd00108: KR 
Click on image for an interactive view with Cn3D
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.
Statistics
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PSSM-Id: 238056
Aligned: 38 rows
Threshold Bit Score: 75.4923
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingputative domain
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Citation:PMID 8181476
  • Structure:1CEA_B, binds 6-aminohexanoic acid
  • Structure:1B2I_A, binds trans-4-aminomethylcyclohexane-1-carboxylic acid

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #              #                             # #     
1NK1_A     98 IRNCIIGkGRSYKGTVSITKSGIKCQPWss-----miPHEHSFLPssyr----gkdLQENYCRNPRGEeGGPWCFTsnp- 167 human
1CEA_B      1 LSECKTGnGKNYRGTMSKTKNGITCQKWss-----tsPHRPRFSPathp----segLEENYCRNPDNDpQGPWCYTtdp- 70  human
1URK       42 SKTCYEGnGHFYRGKASTDTMGRPCLPWns-----atVLQQTYHAhrsda-lqlglGKHNYCRNPDNR-RRPWCYVqvgl 114 human
4758502   191 SDDCYVGdGYSYRGKMNRTVNQHACLYWns-----hlLLQENYNMfmeda-ethgiGEHNFCRNPDAD-EKPWCFIkvtn 263 human
290665     14 DVPCVRReGRDYRGDLNITWTGKPCLPWrgsy-snflPSQFTTAG-----------LTSNYCRNPDGDsEGVWCYTkgve 81  Pacific hagfish
547643    283 DERCFLGnGTGYRGVASTSASGLSCLAWns------dLLYQELHVdsvgaaallglGPHAYCRNPDND-ERPWCYVvkds 355 human
2499868   216 DGDCYTGnGLAYRGTRSHTKSGASCLPWnsvfltskiYTAWKSNApal------glGKHNHCRNPDGD-AQPWCHVwkdr 288 cow
542586    234 TENCYWEdGSTYRGVANVSASGKPCLRWsw------lMKEISDFPe---------lIGQNYCRNPGSVeNSPWCFVdssr 298 fruit fly
1351379   125 RATCYEGqGVTYRGTWSTAESRVECINWns-----slLTRRTYNGrmpda-fnlglGNHNYCRNPNGA-PKPWCYVikag 197 common vampire bat
6434248   325 THWCYVNsGTQYEGTVAQTSSGKQCAPWi-------dSTSRDFNVhrfp----elmNSKNYCRNPGGKkSRPWCYSkpm- 392 Caenorhabditis ele...
Feature 1         #         
1NK1_A    168 -evrYEVCDIPQCS 180 human
1CEA_B     71 -ekrYDYCDILECE 83  human
1URK      115 -kplVQECMVHDCA 127 human
4758502   264 dkvkWEYCDVSACS 277 human
290665     82 -gtdVDYCQLNYCE 94  Pacific hagfish
547643    356 -alsWEYCRLEACE 368 human
2499868   289 -qltWEYCDVPQCV 301 cow
542586    299 -eriIELCDIPKCA 311 fruit fly
1351379   198 -kftSESCSVPVCS 210 common vampire bat
6434248   393 --gqEEYCDVPQCP 404 Caenorhabditis elegans

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