2ESB


Conserved Protein Domain Family
DUSP18_21
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cd14573: DUSP18_21 
dual specificity protein phosphatases 18 and 21
This subfamily contains dual specificity protein phosphatase 18 (DUSP18), dual specificity protein phosphatase 21 (DUSP21), and similar proteins. They function as protein-serine/threonine phosphatases (EC 3.1.3.16) and protein-tyrosine-phosphatases (EC 3.1.3.48), and are atypical DUSPs. They contain the catalytic dual specificity phosphatase domain but lack the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. DUSP18, also called low molecular weight dual specificity phosphatase 20 (LMW-DSP20), is a catalytically active phosphatase with a preference for phosphotyrosine over phosphoserine/threonine oligopeptides in vitro. In vivo, it has been shown to interact and dephosphorylate SAPK/JNK, and may play a role in regulating the SAPK/JNK pathway. DUSP21 is also called low molecular weight dual specificity phosphatase 21 (LMW-DSP21). Its gene has been identified as a potential therapeutic target in human hepatocellular carcinoma. DUSP18 and DUSP21 target to opposing sides of the mitochondrial inner membrane.
Links
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Statistics
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PSSM-Id: 350421
Aligned: 5 rows
Threshold Bit Score: 295.931
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:x x C x x x x x RClick to see conserved feature residue pattern help
Evidence:
  • Structure:2ESB: Human DUSP18 binds a HEPES molecule in the active site; contacts at 4A
  • Comment:based on the structures of some DUSP family members with bound phosphorylated substrates (peptide and non-peptide)
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #                                         #                         
2ESB_A        19 GLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNtlyEDIQYMQVPVADSPNSrLCDFFDPIADHIHSVemkQG 98  human
NP_001089745  22 GLNRISEGLYLASAKAASNRTLLATHRITCVINVSQEIAKneaPELEYVNIPVSDTPDTcLLQYFEDIADKIHTVkagGG 101 African clawed ...
Q9H596        21 SFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNvffEGIQYIKVPVTDARDSrLYDFFDPIADLIHTIdmrQG 100 human
ACO51905      15 RFSKVTESLYLSNKEAAYNRTLLHAHRITCVINVTLEGPVgvpPVPEYLHVPLEDVPETpLRDYFTTVADKIHEIeanGG 94  bullfrog
XP_415295     87 RLSRITPCLYLSDGVAAGNAQLLAANHITTVINVSLELANmlhPGIEYLRIPVADSPTArISACFNSAADLIRSVgerGG 166 chicken

Feature 1             #######                                                                  
2ESB_A        99 RTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNsGFWEQLIHYEFQLFGKNTVHMVSSPVGMIPD 176 human
NP_001089745 102 NTLLHCVAGISRSPTLCLAFLMKYHGLSLQAAHDWVKTCRPIIRPNlGFWTQLMTYEMSLFGKNTVTIIDSPVGPIPS 179 African clawed frog
Q9H596       101 RTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNnGFWEQLINYEFKLFNNNTVRMINSPVGNIPD 178 human
ACO51905      95 CTLVHCVAGISRSATLCLAYLMKHRAMTLLEAHIHLKKCRPFIEPNiGFWGQLIGYEQELYGENTVHLITSPIGIIPS 172 bullfrog
XP_415295    167 RTLLHCAAGVSRSATVCIAYLMKHHAMSLASAHAWVRSCRPIIRPNnGFWRQLIHYEYLLFGINTVHMVHSPFGMIPD 244 chicken

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