Conserved Protein Domain Family
Telomere_reg-2

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pfam10193: Telomere_reg-2 
Telomere length regulation protein
This family is the central conserved 110 amino acid region of a group of proteins called telomere-length regulation or clock abnormal protein-2 which are conserved from plants to humans. The full-length protein regulates telomere length and contributes to silencing of sub-telomeric regions. In vitro the protein binds to telomeric DNA repeats.
Statistics
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PSSM-Id: 462990
Aligned: 147 rows
Threshold Bit Score: 52.5055
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KDE06835      688 PVYVAELTAYLKgldpegkkeeVD-QEVERVEVGLREGEGLVR-RKKGwggELEE-NAVDLAFALMGLQDQY--DIEGFE 762 
XP_015795552  477 PIYVVDCISGLR----------DV-ENCDWNQICLKSTMEIID-KNAS---MIED-YAEDFAISLLNLQDTF--ETPDFV 538 
CDS40641      537 PHYLRECLDGLGgak----hnpDDiASNEVALSCFAHAEELIYrHCGG---AVHE-VAAIFADTLLHTEPPIcpYIEEVN 608 
EJW04874      292 PYSVQQCLKALE----------NP-KNKDNLETTLKLIPNILN-KTSK---RVLErYSCKLFYSILNISEEY---LKKSR 353 
Q22HE2        362 PKHLYDCLLGLR-----------S-DNSKRFELSLKHLNFLIR-KNVD---DLAV-LWEELTNQLLRI-HQIdvWIPQFD 423  Tetrahymena t...
EFA82729      610 KLYLRDCMMEFQ----------TNkHTAESWESALISIASIVW-SNPD---DLDE-LSESVTKSLLHLTNEY--GVDNFE 672 
EGG14925      582 KLYLMDCLMEFQ----------TNkHTPESWESALTSISSIVWnSKPD---DLDE-FSVPLTRSLLHLANEY--GLENFE 645 
XP_003285130  597 KIYLRDCLLELQ----------SSkHTAESWENSLFSISKIVW-SNPD---DLDE-LAQPLASSLLHLSNEY--DLDGFS 659 
Q54J89        603 KIYLRDCLLELQ----------SQkHTAESWENALNSISNIVW-SLPD---DLDE-LSVQLANSLIHLTNEY--DLESFS 665  Dictyostelium...
CAP28845      568 VVYIQDAFEKLL----------EK-ERYEIFEEALYSLKELIE-REAI---GFAD-IAEKLFVRLINLQNLF--GTKNFS 629 
KDE06835      763 HSKRKIIIALVAACPTKVAPCIIEQYFTPSYSVVQRYTMLTALALGA 809 
XP_015795552  539 TLRRDALVKLLTVSPITVATYLTGQFYDNNLDIERRLLILETLAMAS 585 
CDS40641      609 ASRHRALVALAVVSPRRTVHYLTGQLMQSGLAVNQLSAVIAALTDAA 655 
EJW04874      354 KPRNSVLVLLAKLDFNNISNFCINNLFENRLCLASKILIIQIISEIT 400 
Q22HE2        424 EYKKRALVSLCIFKPEQVSKVLIDRFFSAESYVGDKHFLINLFIESA 470  Tetrahymena thermophila SB210
EFA82729      673 VVRHEALVALAVNSTKIVVKYLTDCFYQNTFSLGQRLEILSVLTDAA 719 
EGG14925      646 VIVQESIVALAIHSTGPVVDYLTSTFSKPNYSIGQRLTILSTLIDTA 692 
XP_003285130  660 QHRHEALVALATQSPAIVVPFLTNSFKESNFSVGQRLEILDTIAESA 706 
Q54J89        666 SIRHESLVSLATQSTSLVIPYLTDAFKQKNFSIGQRIEILETISESA 712  Dictyostelium discoideum AX4
CAP28845      630 ETCDLCALLCIKHRPQ-IVPALVRLILSPGQGLQKQNHLLHLIHRAA 675 
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