Conserved Protein Domain Family
Complex1_LYR_SF

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cl40429: Complex1_LYR_SF Superfamily 
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily
The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.
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Statistics
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Accession: cl40429
PSSM Id: 477356
Name: Complex1_LYR_SF
Created: 8-Jan-2020
Updated: 4-Oct-2023
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