Conserved Protein Domain Family
Rep_2

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pfam01719: Rep_2 
Plasmid replication protein
This family consists of various bacterial plasmid replication (Rep) proteins. These proteins are essential for replication of plasmids, the Rep proteins are topoisomerases that nick the positive stand at the plus origin of replication and also at the single-strand conversion sequence.
Statistics
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PSSM-Id: 396331
Aligned: 7 rows
Threshold Bit Score: 133.814
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6LWI0          1 MAKEKARYFTFLLYP--ESI-PQDWQT----KLETLgvPIAISPLHDKDLSsVEGqKYKKAHYHVIYISKNPVTAESVRL 73  Lactobacillus ...
WP_014106744   22 QPYKRGRNWAIVAYP--ESL-PKNWKD----IISQE--PVAISPLHDKDVN-PDG-TKKKKHYHLVLNYKGNKSFEQIDQ 90  Lactobacillaceae
WP_022317769    2 EKQKRTRNFATVVYPtsEKT-PENWQD----ILREQiiPAFISPLHDKDKN-TTG-EVKKAHYHIIIMFEGVKTIEQARE 74  [Ruminococcus]...
CAR41779        2 TKDKRSNKWAFLLYQ--ESA-PDNYLE----VLEELhiPFVLSPWHDRDVNkETG-EIKKAHKHGALFFESLKSYSQVSE 73 
CDD50264       36 lkklKKRHWLYIIYP--ESA-PEDWKE----QLALTgvQFAVSPLHDRDLL-VNG-DLKKAHWHMIVIFDGPSTFLTAAS 106
bgi:05SSU0864  19 EKVPSIRHTAYMFCStvESVsIKNLQEiiklFQETLnpFEIAGIIHDKDID-------TEPHYHIIVRFKNAVWLNSIIN 91 
Q5FLQ6         16 KKIVRARQFTYVQDTdhLKVePKQFQD----FLSKSgaVEWAYILHDKDADqNNK---IRDHYHVVLKYANPQTISKIAN 88  Lactobacillus ...
Q6LWI0         74 kIKRALGDKS-VAKVQivvqSMENMYLYLTHESKdaiaKNKHKYSKHDIAVLNNFDIDRYitLDVEDKDDMLNDVCDLID 152 Lactobacillus ...
WP_014106744   91 -IARALRAPI-PERIN----SLTGAVRYLTHMDN----PEKYQYDSSDIQTFGGFDLENClaLSTGDKRQTLRDMLAFIS 160 Lactobacillaceae
WP_022317769   75 -VFDLIGGVG-IEPIK----SIRAYVRYLCHLDN----PEKAQYSIEDVICCSGADYQSMi-ESPQDKYILLGEIMDYCE 143 [Ruminococcus]...
CAR41779       74 lLTKHLKTPNhVEIIM----SPKGMYDYFIHAEN----PDKTLYDINDIETGCGFELDKF--LTSNNHDKFLSLIIDIIE 143
CDD50264      107 -FREITHGSY-PKVCE----NLRGSFEYFTHKND----PDKAQYSSSDIELFNGFEID----LSAKDVQRIKKELCEIII 172
bgi:05SSU0864  92 kLSQNGFEVQ-SNFFEawkgKVNNAYSYLIHRTEd--aSEKHQYTVDEV-------------IANFDYAERIENIESKIQ 155
Q5FLQ6         89 iFKDK------EQYVQiwngRIDNAYSYLIHETSd--aQNKYRYSPKEV-------------VASFNFEKRIEKIRTSIK 147 Lactobacillus ...
Q6LWI0        153 -----DHNL-------------------ANMREL---RRFLKAHGSEygmPGIKVVNSVlrahtglirLYFDAVYQERKY 205 Lactobacillus ...
WP_014106744  161 -----ENDI-------------------IHLKDL---ADYCMSENAPagwFEILTERNT---------LFIKEYIKSNWQ 204 Lactobacillaceae
WP_022317769  144 -----QKDI-------------------VSYAEL---LKYARENNRA---WFIVLCDNT---------LPVVQYLKSRyw 184 [Ruminococcus]...
CAR41779      144 -----EHNF-------------------IEFNNL---VRYARTENPQ---LLNLIMDKT---------YFFAKYLDSRRY 184
CDD50264      173 -----KHNI-------------------TEYMEFnlyVQYYLEAD-----YFDVASNNT---------YYFNSLINSFRH 214
bgi:05SSU0864 156 -----SNSRkektinvvrnlinkiiagdISFDEAikeVD-----------------------------GY--TLVKYDRE 199
Q5FLQ6        148 rkssfKNDIeeklkd--------yaeniISLYELrksIG-----------------------------DYAFTTPSIQRH 190 Lactobacillus ...
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