2RRA,2KXN


Conserved Protein Domain Family
RRM_TRA2

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cd12363: RRM_TRA2 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
This subfamily corresponds to the RRM of two mammalian homologs of Drosophila transformer-2 (Tra2), TRA2-alpha, TRA2-beta (also termed SFRS10), and similar proteins found in eukaryotes. TRA2-alpha is a 40-kDa serine/arginine-rich (SR) protein that specifically binds to gonadotropin-releasing hormone (GnRH) exonic splicing enhancer on exon 4 (ESE4) and is necessary for enhanced GnRH pre-mRNA splicing. It strongly stimulates GnRH intron A excision in a dose-dependent manner. In addition, TRA2-alpha can interact with either 9G8 or SRp30c, which may also be crucial for ESE-dependent GnRH pre-mRNA splicing. TRA2-beta is a serine/arginine-rich (SR) protein that controls the pre-mRNA alternative splicing of the calcitonin/calcitonin gene-related peptide (CGRP), the survival motor neuron 1 (SMN1) protein and the tau protein. Both, TRA2-alpha and TRA2-beta, contains a well conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), flanked by the N- and C-terminal arginine/serine (RS)-rich regions.
Statistics
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PSSM-Id: 409798
Aligned: 22 rows
Threshold Bit Score: 117.716
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2RRA; Human Tra2 beta RRM protein binds RNA (GAAGAA), contacts at 4A.
  • Structure:2KXN; Human Tra2beta1 RRM binds RNA (AAGAAC), contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       #   ##                          # #        # # # #                     ####  #
2RRA_A     15 NCCLGVFGLSLyTTERDLREVFSKYGPIa---DVSIVYDQQsrrsRGFAFVYFENvDDAKEAKERANGMelDGRRIRVDF 91  human
3929384   104 SRCIGVFGLNTnTTQQKVRELFNKFGPIe---RIQMVIDAHthrsRGFCFIYFENlGDARVAKDACTGMevDGRRIRVDY 180 Drosophila virilis
Q54Y98    112 SNVLGVFGLAPqTEERDLKDEFSRFGKId---HVDLIMDRKtgrsKCFGFVYFENkEDAVRAKEECQDLqlHGKSIRTDF 188 Dictyostelium disc...
EFX90042  116 TRCLGVFGMGLyTTETELQHVFAKYGPLe---KVQVVKDAKtgrsRGFAFVYFESlEDAKLAKEQCTGLeiDGRRIRVDY 192 common water flea
EGO27172   82 SNVLGVFGLSIrTQERDLDEEFSRFGRVe---KVTIVYDQRsdrsRGFGFIKMSTvEEATRCIQELNGVdlNGRRIRVDY 158 Serpula lacrymans ...
NP_585779  59 SRAIGIFGLGAhITEDDVRDLLKERISEilnyRVVIVYDKYkrmsKGYGFVQFDSvDDAITARNRLVGQtiKGKEIRVDY 138 Encephalitozoon cu...
CCD82415   74 SRCLGVFGLSLhTQERNLYDIFSQYGNIe---DVQLVFDNYtgrsRGFGFVYFTHvADAKAAKADAHGMeiDGRPIRCDF 150 Schistosoma mansoni
CBY18192  130 SRCLGVFNLGRrTTDEEFRRVFERYGKMe---SCKLVYDQKreesRGFGFITYDSiEDAIYAKKDATGMdiNGHEIRIDY 206 Oikopleura dioica
EDQ90533    1 SNVLGVFGLSRdTDERQLDSIFGDFGQLe---KCIIIHDRQngrsRGFGFVTFVSdEDAQRAREKLNGAriDGRNVRVDF 77  Monosiga brevicoll...
EHY65492  134 VNVLGIFGIDIrVTEDELKQWLNEKLESlpftKTELVLDKYtgysRGYAFVYFDTvEEATAAKGKLTDQmlNGSIVRVEY 213 Nematocida sp. 1 E...
Feature 1     ###
2RRA_A     92 SIT 94  human
3929384   181 SIT 183 Drosophila virilis
Q54Y98    189 SAT 191 Dictyostelium discoideum AX4
EFX90042  193 SIT 195 common water flea
EGO27172  159 SVT 161 Serpula lacrymans var. lacrymans S7.9
NP_585779 139 SIE 141 Encephalitozoon cuniculi GB-M1
CCD82415  151 SIT 153 Schistosoma mansoni
CBY18192  207 SIT 209 Oikopleura dioica
EDQ90533   78 SVT 80  Monosiga brevicollis MX1
EHY65492  214 SIT 216 Nematocida sp. 1 ERTm2

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