Conserved Protein Domain Family
DsbA_FrnE

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cd03024: DsbA_FrnE 
DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.
Statistics
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PSSM-Id: 239322
Aligned: 79 rows
Threshold Bit Score: 148.112
Created: 22-Dec-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:based on known function of DsbA
  • Comment:CXXC motif
  • Citation:PMID 9655827

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #  #                                                                    
AAC18100      6 VEIWTDVVCPWCYIGKRRFERALAAFda---keDVRVHWRSFELDPAALRVTdet---ipERMLRRQGIPPEQAAellag 79  Streptomyces ros...
YP_018562     5 MKVYSDFICPFCFLAKGPLDEVAKEK-------DVEIEWMPFELRPSPYSKId------pWNEPEKLGSWDAFIL----- 66  Bacillus anthrac...
AAV47258     10 ITVFSDYVCPFCYLGRESLRQYQSTRe-----dELEVDWHPFDLRSGKRNPDgsidhsvdDGKDDEYYEQAKESVr---- 80  Haloarcula maris...
P39598        5 IKVYSDYVCPFCFVGKAAFEEAIKGK-------DVEVEWMPFELRPSPSPQLd------pVNDPSKQYMWQTSIQ----- 66  Bacillus subtilis
NP_444183     5 ITVYSDYVCPFCYLGRQSLETYREARdda--apALEIDWQPFDLRSRQRRPDgtldesvdSGKDEAYYEEARQNVerl-- 80  Halobacterium sa...
ZP_00283366   6 VEVNYDFICPWCWIGQRNLAAALAETga---haAVSIRYVPFELNPAMPAEGmd----rrAYRSRKFGSWARSQImda-q 77  Burkholderia fun...
ZP_00597187   6 IIITYDFICPWCWIGHQSLKAGIEQAgm---agRFRSQYQPYELNPDMPKPSsn----rkAYRSRKFGSWERSQVlda-e 77  Ralstonia metall...
NP_522470     5 VTITSDFICPWCLIGERRLAKAIGALpg---dvAVELKWRPFELNPAMRPEGmd----rqTYRSLKFGSWERSRMlda-h 76  Ralstonia solana...
ZP_00216223   6 IQVTYDFICPWCWIGHEHLKTALREVdl---avAPTVKYLPYELNPTMPKDGid----rkAYRSAKFGSWARSQAmda-d 77  Burkholderia cep...
ZP_00167999   9 VEAYFDLICPWCLIGKRHLETAIDLLarerpdvTVQLEWRSYPLIPATPPDGip----yrDFYVARLGSPQAVAVrqa-q 83  Ralstonia eutrop...
Feature 1                                                                                       
AAC18100     80 vsAQAEAEGLEYHLDRArp-cnTFDAHRLAHHAGTr---gLAETFQERLMCAYTAEGVSVGDhpTLLALAEEAGlda-aa 154 Streptomyces ros...
YP_018562    67 --PTAKKLGIDMRLPRVsphpyTHLAFEGCQFAKEr---gLGNEYHHRVFTAFFQEEQNIEDidVLTKLAVEVGlpe-ae 140 Bacillus anthrac...
AAV47258     81 --RLQAKYDVEMDLDIAtd-idSLPAQIASYYVKEhydyeTWLAFDVAVFEALWQDGQDIGDedLLVELAEDAGvdg-de 156 Haloarcula maris...
P39598       67 --PMAEKLGVEINFPNVsphpyTDLAFEGFHFAKEy---nKGHEYNTRVFQAFFQEDQNIGDidILTKLAEEVGldg-as 140 Bacillus subtilis
NP_444183    81 reEYGADEMSTDLVGDVd----GFRAQVASLYVKEtf-peQWLAFDEGVFAALWADDRDVGDadVLADIADGVGldg-ee 154 Halobacterium sa...
ZP_00283366  78 vtAAGLAAGVHFNYDKVlrtpsTRLAHRLMQFAQQrndpqATAALYQAIYAAYFSEGRDIGSldTLVAITAEHAfda-da 156 Burkholderia fun...
ZP_00597187  78 vaAAGKRVGLAFNYDRIlvtpnTRLAHRLMRYVLDqd-aaRADDLFSAVMEAYFTRGQDIGSldVLVDIAVSIGfda-ag 155 Ralstonia metall...
NP_522470    77 tvEAARDDGIAFDYAAIaktpnTFLAHRLNWFAARr---gLATPIANAVFSAYFEHGRDIGDaaVLADIAAENGlgr-de 152 Ralstonia solana...
ZP_00216223  78 vtLAGKRAGVEFNYDRVavtpnTRLAHRLMFLAQSkgnaaRTEALFEAIFSAYFSEGQDIGMaeVLVSLAESAGfda-de 156 Burkholderia cep...
ZP_00167999  84 viAAAREAGLTLALDRIetfpnTMLAHRLVRFVREqdgaaAAATLVDNLFMRYFMRGANIGDgqVLREALTECGipsple 163 Ralstonia eutrop...
Feature 1                                                                  
AAC18100    155 AAEVLAGDAHa-eDVRADEDRAARLGv---GGVPAFVIGgRWSVSGAQpa-eLLTGLLE 208 Streptomyces roseofulvus
YP_018562   141 FKDTLVTRKY---KEKHQEAIQHAYDeaniMAVPTVMIG-DEVIQGLAsk-eTLERVID 194 Bacillus anthracis str. 'Ames Ancestor'
AAV47258    157 IRSALADGALr-sEVRENFTAAKRQGi---TGVPTFAYD-GHAARGAVpp-eQLERLVE 209 Haloarcula marismortui ATCC 43049
P39598      141 FKSALETRTY---QDVQRQALKHAYEeadiTAVPTFIIG-DTVIPGAAgk-dVFEKAIS 194 Bacillus subtilis
NP_444183   155 IRTVVDDEAWr-dRLRDEFADAREAGi---TGVPTFVYD-GHGARGAVpp-sQLERLVE 207 Halobacterium salinarum NRC-1
ZP_00283366 157 VRASLQGSAGn-eAIEAARARAGSLGi---QAVPTIRID-GDVISGAQpp-aVFINALR 209 Burkholderia fungorum LB400
ZP_00597187 156 VREYLNGSAGe-tSVVAQELQAQFDGv---RSVPTYRVG-NQRITDGQpp-qHFARVLQ 208 Ralstonia metallidurans CH34
NP_522470   153 VSAFLAGDEGt-rDVREAERAVQAGGv---RSVPLFDID-GETVSGAQsv-aAFEAALR 205 Ralstonia solanacearum GMI1000
ZP_00216223 157 VRSFLATNDGe-rEVVADELRAAATGi---RSVPTIHVG-GVPVSGAQpv-sVLAQVLR 209 Burkholderia cepacia R18194
ZP_00167999 164 QGTPVQHDMDwlpPLNGPDDPPPRAG----LGVPHFIFNgTHSVSGSRppaaLLEAMLR 218 Ralstonia eutropha JMP134

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