Conserved Protein Domain Family
GEF_RalF

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NF038045: GEF_RalF 
T4SS guanine nucleotide exchange effector RalF
RalF, a virulence factor secreted by type IV secretion systems (T4SS), is a guanine nucleotide exchange factor that acts on host cell ADP-ribosylation factors.
Statistics
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PSSM-Id: 468325
Aligned: 11 rows
Threshold Bit Score: 521.974
Created: 11-Oct-2024
Updated: 3-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_080580413      5 MDSLLKNEVIKLFNDKPKSGIARIKK-WCTDNNQ-DFIAETAKIFYEEKSNLNLEFVGDYLGTDGVDNQKVLESFTKQFD 82  Rickettsia p...
1_ncbifamImport   1 EIEKAQREIIEAFNAKPKNGINKIKE-ICEQYKI-SPNEEIAEFFHQQRKNLDLEAVGDYLSSPEAENQQVLKAFTSQMN 78 
WP_018578688      4 KIEEASREIIELFNAKAKNGIARIKE-ICDKENI-SSAETIGEFLYQQRQNLDLESVGDYLSGPEEENKEALQAFTGQLN 81  Legionella s...
WP_028385386      4 KITTAQREIVEAFNTKPKNGIQKIKDlLVGEEEV-QVEEEIAEFFIKQKQNLDLEAVGDYLSLPDAESQAVLSAFTPKLD 82  Legionella m...
WP_058472902      4 KITAAQRDIAEAFNIKPKNGINMIKDlLTGEENV-QVAEEIAEFFIQQKQNLDLDAVGDYLGGKEAENQAVLNSFTLNFD 82  Legionella q...
WP_058514496      5 EIEKAQNEIIASFNSNPKEGIQQIKN-ICGIHNI-ASAEQIADFFHRQQHKLDLNAVSDYLSKPDKENQEVLQKFTSQIN 82  Legionella s...
WP_150866241      5 ELEKAQNEIITSFNSDPKKGIQLIKN-ICSTHGI-DSAEQIADFFHRQKHKLDLDAVSDYLSKPDEESKKVLQNFTSQIN 82  Legionella l...
WP_027272333      5 ELEKARNEITTSFNSDPKIGIQLIKN-ICSIHCL-DSAEQIASFFHRQRHKLDLNAVSDYLSKSDEENKKILKNFTSQIN 82  Legionella s...
WP_058445186    113 DIQARKREIAHTFNVKAKDGIQKIKD-ICQAHNVkEVGKQIADFFHEEHRNLDLEAIGDYLSSPDAENKEALQAFTARIN 191 Legionella f...
WP_126044610      5 FSEDIKIQIAKQFNKKPKDGINAIIR-FCDENGIeNVDKQIAEFFIEQKENLDLEAVGDYLSGENILNQKVLKAFTQQFN 83  Candidatus A...
WP_012149483      4 MDSLVQNEVIKLFNDKPKSGIVRIKQ-WCADNNK-DFAKETAQFFYEEKSNLNLEFVGDYLGTDGIDNKTVLESFTKQLN 81  agent of ric...
WP_080580413     83 FKEKDYLESLRRFLQSFKLPGEAQKIDRLVESFGTHYYEQNl----NIDINSKDAAYILAYQTIMLNTDLHNPSIAKSKK 158 Rickettsia p...
1_ncbifamImport  79 FNGQSFVEGLRTFLKTFKLPGEAQKIDRLVQSFSGAYFQQN-----PDVVSNADAAYLLAFQTIMLNTDLHNPSIPEKNK 153
WP_018578688     82 FEGQSFVNGLRIFLKAFKLPGEAQKIDRLVKSFSEAYCQQN-----PDVIANEDAAYLLAFQTIMLNTDLHNPSIAEQNK 156 Legionella s...
WP_028385386     83 FGGQSFITGLRTFLKAFKLPGEAQKIGRLVESFSQTFSEQN-----PGVFINSDAAYLLSFQAIMLHTDMHNPSIAEKNK 157 Legionella m...
WP_058472902     83 FEGQDFTTAFRTFLTSFKLPGEAQQIDRIVASFGKAYFNSN-----PGIFADSDAAYVLAFAVMMLQTSLHSSSVAPKDK 157 Legionella q...
WP_058514496     83 FRGQSFTEGFRVFLNTVKLPSEAQKIDRLVQSFGETYHQQNy----KGHIADKDAAYILAYQVLILNTSLHNPKLRPKDR 158 Legionella s...
WP_150866241     83 FREQSFTEGFRVFLNTIKLPSEAQKIDRLVQSFGETYHQQNy----ENHIATIDAAYILAYQVLILNTSLHNPKLRPKDR 158 Legionella l...
WP_027272333     83 FRGQSFTEGFRVFLNSVKLPSEAQKIDRLVQSFGETYHQQNy----KNHIANKDAAYILAYQVLILNTSLHNPKLRPKDR 158 Legionella s...
WP_058445186    192 LAGQKFLPALRNYLKTFLLPKESQKIERLLESFGEAYCMQNp----QGNLADKTAGYMLAVQAMFMATTFHNPQAA-KYK 266 Legionella f...
WP_126044610     84 FQNKTFTEGLREFLFSHKLPGEAQKIDRLVQSFSDIYYGQQqesahEQIFSDADAVYVLAFQTIMLNTDLHNSAI--KDH 161 Candidatus A...
WP_012149483     82 FKEKDYLESLRGFLQSFKLPGEAQKIDRLVESFGTNYYEQNl----NGEIKSKDAAYILAYQTIMLNTDLHNPSIVKPKK 157 agent of ric...
WP_080580413    159 MTFEQLKNNLKGTN------ESKNFNDNFLKKIYDEIEAKPFKLNFVDSSPGYQINNISSQNDKTFKQLNQFL--EEKRN 230 Rickettsia p...
1_ncbifamImport 154 MTVDGLKRNLRGGN------NGGDFDAKFLEELYSEIKAKPFELNFVKTSPGYELTSTTLNKDSTFKKLDSFLh-STDVN 226
WP_018578688    157 MTLDGLVRNLKGTN------NGGDFNPEFLRTIYNEIKAKPFEFNFVKVNPGYEINFGASDNDPAFEKLNSIMg-SSVID 229 Legionella s...
WP_028385386    158 MTFEALVKNVRGCN------DGQDFDRAFLQEMYDQLKREPFELNFVKMNPGYEFHSSILGDDPTFIKLDSLL--QSTAN 229 Legionella m...
WP_058472902    158 MTLESFENMLRGCNtekdseNKKDYDKVFLKKIYDDIKGKPFEFNFVKTNPGYEFNTSILGTDPTFKKLDSLL--QSNTK 235 Legionella q...
WP_058514496    159 LPLESLKICLHGLN------NGKNFEDTFLKKIYEEIKHKPFEFNLVKTAPGYQLTSSTLTNDPVLKKLDLLFq-LPNSN 231 Legionella s...
WP_150866241    159 LTLSALKICLKGLN------NGQDFEDAFLKKIYEEIKCKPFEFNLVKTTPGYLLTSSTLDDDLMFKKLDLLLq-SSDST 231 Legionella l...
WP_027272333    159 LTLNALKICLQGLN------NGNNFEDAFLKKIYSEIKCKPFEFNLVKTTPGYLLTSSTLDNDCMFKELDLLLq-SPTSK 231 Legionella s...
WP_058445186    267 MDFKQVKNILKGDN------GGADFDEDFLQEIYDDIKANPFELNFVKASPGYEFNSPTLDHDSTFNKLDLLL--QSPAK 338 Legionella f...
WP_126044610    162 MSIDSLKQNLRGVN------GGENFPDEFLLGLYEEIKENPFEFNFTKISPGIQMNTSLLDYDQTFKSLKTFMneAGNGQ 235 Candidatus A...
WP_012149483    158 MTFEQLKNNLKGTN------ESQNFNDTFLKKMYDGIKAKPFVLNFVDSSPGYEIYNISSQNDQTFKKLNKFL--EEKST 229 agent of ric...
WP_080580413    231 IQNIFPKLQn-NNLTIEFKNPKTFLSKFTGYKGSVIIKDEKSGA--AEIQVYKPSIFSRWFLGEKSKIIIQPlREEgrqp 307 Rickettsia p...
1_ncbifamImport 227 INTVFPGIG--DNVKTTVDQPKSWLSFFTGYKGTITLTDNKTSAq-ATIQVYTPNIFSKWLFGEQPRVIIQP-GQT---- 298
WP_018578688    230 PKNLIPGIS--DSVKATVAKPKPWLAFLTGYEGTILLADEKTKGe-ASIQIYKPGIFSKLFFGEQPKVIVQPaGTN---- 302 Legionella s...
WP_028385386    230 PKGVFPHVS--ADVKASVDKPSSWLNVFTGYEGTLTLTDDSAKAs-ATIQVYKPGILSKWLFGEQPRIIIQPvKQDgi-e 305 Legionella m...
WP_058472902    236 AQDVFPGIS--ADVMATVDKPNSWLNILTGYQGTITLTDDNAKAa-VTVQVYTPGIFSKLLFGDQPKVIIQPvNQDgt-d 311 Legionella q...
WP_058514496    232 IQEIFPEID--DTIKVTLDKPKVWLKAFTGYEGTIKFATKTGKEl-VNMQIYKPSFVSKWLFGEQPKVIIQPvYQDeh-- 306 Legionella s...
WP_150866241    232 IQEIFPEIA--NNITVTFDKPKAWLKAFIGYEGTIKFTTESGREl-ANIQIYKPSLVSKWLFGAQPKVIIQPiDQDen-- 306 Legionella l...
WP_027272333    232 IQKIFPELA--DNINITLVKPKAWLKTFTGYEGTIKFAAETGKEl-ANIQIYKPSLISKWLFGEQTKVIIQPiYHDen-- 306 Legionella s...
WP_058445186    339 AQVIFPGIG--EHVKATADQPKSWLSILTGYKGTITLTNENTQEilATLQVYSPSVISKWIFGDTHRVIIQPiSQNgl-v 415 Legionella f...
WP_126044610    236 LKNVFPNISnaDSLEAQVDKPRSLLANLMGYNGTLNLTDKETGAk-CSVQIYEPNIFSKILFNDKPKIIIQPlGDEn--- 311 Candidatus A...
WP_012149483    230 IQDVFSKLQn-NNLTAEFKNPKTLLNKFTGYEGSVIVKDEKGGK--ATIQVYKPSVFSRWFLGEKSKIIIQPlSEEgkqp 306 agent of ric...
WP_080580413    308 sEQSLKLAAQITASFETKVTSIKATYDYLKEDLKSQYD 345 Rickettsia prowazekii
1_ncbifamImport 299 -KESIDLAAKAAADFSSPVKNFKATYDYEVGDLIKAYD 335
WP_018578688    303 -KASIDLAAKVAAGFKTPVSSIKATYDYEHKDLESAYQ 339 Legionella shakespearei
WP_028385386    306 hRASIDLAAKIAADFQSPVSSIKATYNNDLVDLIDAYD 343 Legionella moravica
WP_058472902    312 pKASIDLAGKIAAGFQTPVSTIKATYDNDKADLIKAYD 349 Legionella quateirensis
WP_058514496    307 sKETIDLAAKIAVHFKSPVNSFKATYDYELSDLINAYD 344 Legionella santicrucis
WP_150866241    307 pKEAIELAAKIAVLFESPVNSFKATYDYELSELISAYN 344 Legionella longbeachae
WP_027272333    307 pKEAIDLAAKIAVHFESPVNNFKATYDYELNELIKAYD 344 Legionella sainthelensi
WP_058445186    416 aQAKIDLAAKIAARFELPVTHVKATYDYLKDDLQAAYN 453 Legionella feeleii
WP_126044610    312 qDHSLKLAAQVEASFRTPPETFKSTYGYEADSMEKEYR 349 Candidatus Aquarickettsia rohweri
WP_012149483    307 sEQSLTLASQITASFETKVTSVKATYDYLKEDLKSRYE 344 agent of rickettsialpox
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