Conserved Protein Domain Family
ATS
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pfam15445: ATS 
acidic terminal segments, variant surface antigen of PfEMP1
ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
Links
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Statistics
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PSSM-Id: 373851
Aligned: 24 rows
Threshold Bit Score: 620.285
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8IBD8 2097 TIPFGIALALG-SIAFLFLKKKTKSTI-DLLRVINIPKSDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSgtDS---G 2171 Plasmodium falcipar...
O96294    6 AFPLSVGIAFA-ALSYFLLKKKSKFSV-DLLRVLNIPKGDYEMPTLKSKNRYIPYRSGQYKGKTYLYVEGDT--DEekyM 81   Plasmodium falcipar...
Q9NFB4  894 MVPAGIGVALTlGLLLFKMRTKPKHEV-DMIRILQMSQNKYGIPTTKSPNKYIPYASQRYKGKTYIYMEGDSg-DEdkyI 971  Plasmodium falcipar...
Q8I218 3018 TIPFGIALALT-SIALLFLKKKPKSPV-DLIRVLDVHKGDYGMPTLESKNRYIPYRSGTYKGKTYIYMEGDTsgDDdkyM 3095 Plasmodium falcipar...
Q8IAK2 2448 TIPFGIALALG-SIAFLFIKKKPKSPV-DLIRVLDIHKGDYGMPTLKSKNRYIPYASDTYKGKTYIYMEGDSdsGH---- 2521 Plasmodium falcipar...
Q8IBW9 1747 TIMWSVGIGFA-AFTYFYLKKKTKASVgNLFQILQIPKGDYDIPTLKSSNRYIPYASDRYKGKTYIYMEGDSsgDEk-yA 1824 Plasmodium falcipar...
Q8IIZ5 1753 TLAWSVGIGFA-AFTYFFLKKKTKASVgNLFQILQIPKSDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSgtDS---G 1828 Plasmodium falcipar...
Q8IBX0 1631 TIMWSIGIGFA-AFTYFFLKKKTKSSVgNLFQILQIPKSDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSgtDS---G 1706 Plasmodium falcipar...
Q9U0G6 1746 AFPWTVGVAFM-ALSYWVMKKKSKPRV-DLFSVMEIPQNDYGMPTLKSKNRYVPYSSGKYRGKTYLYVEGDSgtDS---G 1820 Plasmodium falcipar...
Q8IFQ4 1743 TIMWSIGIGFA-TFTYFYLKKKTKSSVrNLFQILQIPKGDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSgtDS---G 1818 Plasmodium falcipar...

Q8IBD8 2172 YTDHYSDITsSSESEYEELDINDIYAPRAPKYKTLIEVVLEPSGNNTTAsgnnttasgnnttasgnnttasdtqndiQND 2251 Plasmodium falcipar...
O96294   82 FMSDTTDIT-SSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNT----------------------------LGD 132  Plasmodium falcipar...
Q9NFB4  972 GNISSSDIT-SSESEYEEMDINDIYPYTSPKYKTLIEVVLEPSKSNGNTpskgd-------------------gntvGDD 1031 Plasmodium falcipar...
Q8I218 3096 FLSDTTDIT-SSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNTpskgd-------------------gntlGDD 3155 Plasmodium falcipar...
Q8IAK2 2522 YYEDTTDIT-SSESEYEEMDINDIYVPDSPKYKTLIEVVLEPSKRDT------------------------------PSS 2570 Plasmodium falcipar...
Q8IBW9 1825 FMSDTTDVT-SSESEYEELDINDMYVPGSPKYKTLIEVVLEPSKRDTMStqs-----------------------diPLN 1880 Plasmodium falcipar...
Q8IIZ5 1829 YTDHYSDITsSSESEYEEMDINDIYAPRAPKYKTLIEVVLEPSKRDIPSdd-------------------------iPNN 1883 Plasmodium falcipar...
Q8IBX0 1707 YTDHYSDITsSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTAsgkntps---------------dtqndiQND 1771 Plasmodium falcipar...
Q9U0G6 1821 YTDHYSDITsSSESEYEELDINDIYPYQSPKYKTLIEVVLEPSKRETNSgd-------------------------iPND 1875 Plasmodium falcipar...
Q8IFQ4 1819 YTDHYSDIT-SSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNTl---------------------------GDD 1870 Plasmodium falcipar...

Q8IBD8 2252 GIPSsK-ITDNEWNTLKDEFISQYLPNTEpN---NNYRSGNSPTN-TNITTTSRH-NMEEKPFITSIHDRNLYTGEEISY 2325 Plasmodium falcipar...
O96294  133 MVGT-TiFTDEEWNQLKDDFISQYLPNTEpN---NNYRSGNSPTN-TNNTTTSHD-NMGEKPFIMSIHDRNLYTGEEISY 206  Plasmodium falcipar...
Q9NFB4 1032 MVPTtNtFTDEEWSELKHDFISNMLQNQP-NdvpNDYKSGDIPFN-TQPNTLYFD-NNQEKPFITSIHDRDLYTGEEISY 1108 Plasmodium falcipar...
Q8I218 3156 MIPTtNtFTDEEWNELKHDFISQYIQSRLpMdvpQYDVSTELPMNiTEVNVLDVG--INEKPFITSIHDRDLYSGEEINY 3233 Plasmodium falcipar...
Q8IAK2 2571 DAPM-NkFTDDEWNQLKQDFISGILENEQ-KdlpKNNISGNTPMN-TQPNTLYFN-KPEEKPFITSIHDRDLYSGEEINY 2646 Plasmodium falcipar...
Q8IBW9 1881 DKLDsNkLTDEEWNKLKQDFIS-ILQNPQ-NdlpQNNISGNIQMD-THPSVSILHdDMEEKPFITSIHDRDLHNGEEVTY 1957 Plasmodium falcipar...
Q8IIZ5 1884 DTPSsK-ITDNEWNTLKHDFISNMLQNTQ-NtepNMLGY-NVDNN-THP-TMSRH-NVEEKPFIMSIHDRNLLNGEEYSY 1957 Plasmodium falcipar...
Q8IBX0 1772 GIPSsK-ITDNEWNTLKDDFISQYLQSEQpKdvpNDYSSGDIPFN-TQPNTLYFD-KPEEKPFIMSIHDRDLYSGEEYNY 1848 Plasmodium falcipar...
Q9U0G6 1876 NTPAnKpITDEEWNTLKDEFISNMLQSTQ-NtepNILHD-NMHYN-THPNTLYFD-KHEEKPFIMLIQDRNLLIREEYSY 1951 Plasmodium falcipar...
Q8IFQ4 1871 MVPTtNtFTDEEWNELKHDFISNMLQNQp-----NDYKSEDIPLN-TQPNTLYFN-KPEEKPFITSIHDRNLYSGEEYSY 1943 Plasmodium falcipar...

Q8IBD8 2326 NI--------NMSTNSMDD---------------------PKYVSNNVYSGIDLINDTLSGNKHIDIYDEVLKRKENELF 2376 Plasmodium falcipar...
O96294  207 NI--------NMSTNTNNDi--------------------PKYVSNNVYSGIDLINDTLSGNKHIDIYDEVLKRKENELF 258  Plasmodium falcipar...
Q9NFB4 1109 NI--------HMSTNSMDD---------------------PKYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELF 1159 Plasmodium falcipar...
Q8I218 3234 NI--------NMSTNTNNDi--------------------PKYVSNNVYSGIDLINDTLSGNKHIDIYDEVLKRKENELF 3285 Plasmodium falcipar...
Q8IAK2 2647 NI--------NMSTNSMDD---------------------TSYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELF 2697 Plasmodium falcipar...
Q8IBW9 1958 NInlddhknmNFSTNHDNIp--------------------PKNNQNDLYTGIDLINDSISGNHNVDIYDELLKRKENELF 2017 Plasmodium falcipar...
Q8IIZ5 1958 NV---------NMVNSMNDi--------------------PMSGKNDVYSGIDLINDSLSGGEPIDIYDEVLKRKENELF 2008 Plasmodium falcipar...
Q8IBX0 1849 NV--------NMSTNSMDDi--------------------PINSHNNVYSGIDLINDTLSGNKHIDIYDEVLKRKENELF 1900 Plasmodium falcipar...
Q9U0G6 1952 NM----------STNSGGNgsysgispisdnpdslsdkngPTSGNHNLYSGTDLINDALSGD--YDIYDEMLKRKENELF 2019 Plasmodium falcipar...
Q8IFQ4 1944 NI--------NMSTNSMDDi--------------------PINRDNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELF 1995 Plasmodium falcipar...

Q8IBD8 2377 GT-NHTKKnTSTNSVAKLT-NSDPIHNQLELFHKWLDRHRDMCEKL--KN-DNERLAKLKEEWENET--HSgdinsgips 2449 Plasmodium falcipar...
O96294  259 GT-NHVKQ-TSIHSVAKNTySDDAITNKINLFHKWLDRHRDMCEKW--EN-HHERLAKLKEKWENDNd-GG--------- 323  Plasmodium falcipar...
Q9NFB4 1160 GT-NHPKN-TSNNSVAKLT-NSDPIMNQLDLLHKWLDRHRDMCDKW---NtKEDILNKLNEQWNKDNnvGG--------- 1224 Plasmodium falcipar...
Q8I218 3286 GT-NHTKN-TSNNSVAKNT-NSDSIMNQLDLLHKWLDRRRNMCEKWekHN-KEELLDKLNEQWNKDNd-GI--------- 3351 Plasmodium falcipar...
Q8IAK2 2698 GT-NYKKN-TSNNNVAKLT-NSDPIMNQLDLLHKWLDRHRDMCEKW--KS-KEDILHKLNEQWNKDNd-GG--------- 2761 Plasmodium falcipar...
Q8IBW9 2018 GT-NHTKH-TTTNSITKKT-HNDPIVNQINLFHKWLDRHKNMCEQWd-KHkKEELLDKLKKEWEQDYnnNSddihts--- 2090 Plasmodium falcipar...
Q8IIZ5 2009 GT-NHVKQ-TSIHSVAKPI-SDDPIHNQLELFHTWLDRHRDMCEKW--EN-HHERLAKLKEEWENET--HSgnth----- 2075 Plasmodium falcipar...
Q8IBX0 1901 GT-NHVKQ-TSIHSVAKLT-NSDPIHNQLELFHKWLDRHRNMCEKW--EN-HHERLAKLKEEWENET--HSgnth----- 1967 Plasmodium falcipar...
Q9U0G6 2020 GT-NHTKH-TTTNRVATQI-CDDPITNQLNLFHKWLDRHRNMCEKW--EN-HHERLDKLKELWDNET--HSgnkhngiqs 2091 Plasmodium falcipar...
Q8IFQ4 1996 GTkHHTKR-TSTQNVAKPA-RDDPIHNQLDLFHKWLDRHRDMCKKW--NN-KEGLLDKLKEEWNKDT--NSgklsdni-- 2066 Plasmodium falcipar...

Q8IBD8 2450 gklsdipsdnnihsdihpsdihsgklsDIPSGKQ-------VLNTDVSIQIHMDNPKTTNEFtyvdsnpnqvddTYVDSN 2522 Plasmodium falcipar...
O96294  324 ---------------------------NVPSDNH-------VLNTDVSIEIDMDNPKPINQF------------SNMDIN 357  Plasmodium falcipar...
Q9NFB4 1225 ---------------------------DIPNDNK-------MLNTDVSIQIDIDENKGKKDL------------SNMDT- 1257 Plasmodium falcipar...
Q8I218 3352 ---------------------------NVPSDNR-------SLNTDVSIQIDMDENKGKKEF------------SNMDTN 3385 Plasmodium falcipar...
Q8IAK2 2762 ---------------------------NVPIDNR-------SLNTDVWIEIDMDDPKGKKEF------------SNMDT- 2794 Plasmodium falcipar...
Q8IBW9 2091 ------------------------dnnivsTVNH-------VFNTDVSIQIDMDDPNPVNPF------------TNMYTN 2127 Plasmodium falcipar...
Q8IIZ5 2076 ----------------------------psdSNK-------TLNTDVSIQIHMDNPKPINEF------------TNMDTY 2108 Plasmodium falcipar...
Q8IBX0 1968 ----------------------------psdSNK-------TLNTDVSIQIHMDDPKPINQF------------------ 1994 Plasmodium falcipar...
Q9U0G6 2092 nipss---------dihpsdihsgklsDTPSDNNihsdipyVLNSDVSIQIHMDNPKPTNED------------NVVDCN 2150 Plasmodium falcipar...
Q8IFQ4 2067 --------------------hsdnkpgDIPSDNH-------VLNSDVSIQIDMGNPKYINQF------------TCVDSN 2107 Plasmodium falcipar...

Q8IBD8 2523 PDNSSMDTIledleky---nepyydvQDDI-YYDVH-DH---------DASTVDSNAM--DVPSKVQIEMD-VNT---KL 2582 Plasmodium falcipar...
O96294  358 VDTPTMDNM-----------------EDDI-YYDVN-DNdddndqpsvYDIPMDHNKVdvDVPKKVHIEMKiLNNtsnGS 418  Plasmodium falcipar...
Q9NFB4 1258 --------Ild-------------dmEDDI-YYDVN-DNdddndqpsvYDISMDHNKVdvDVPKKVHIEMKiLNNtsnGS 1314 Plasmodium falcipar...
Q8I218 3386 VDTPTMDNIlddletcn--epfydiyEDDI-YYDVN-DEnp-----svDDIPMDHNKV--DVPKKVHVEMKiLNNtsnGS 3454 Plasmodium falcipar...
Q8IAK2 2795 --------Ild-------------diEDDI-YYDVNdDEnp-----svDNIPMDHNKV--DVPKKVHVEMKiLNNtsnGS 2845 Plasmodium falcipar...
Q8IBW9 2128 SDNSTMDNIlngmekhr-epyfydiyEDDItYFDID-DEktpmgdiyvDHNNVNSNNM--DVPNKVHIEMNiVNNk-kEI 2202 Plasmodium falcipar...
Q8IIZ5 2109 PENSTMDTIlddldky---kepyydvQDDI-YYDVNdDN---------DISTVDSNNM--DIPSKVQIEMD-VNT---KL 2169 Plasmodium falcipar...
Q8IBX0 1995 ---TNMDTIledleky---nepyydvQDDI-YYDVN-DH---------DTSTADSNAM--DVPSKVQIEMD-VNT---KL 2051 Plasmodium falcipar...
Q9U0G6 2151 Pv------------------------GNNI-YVDNNpNQtf-----psNPNPVENNTYv-NAPTNVQIEMD-VNNh--KV 2196 Plasmodium falcipar...
Q8IFQ4 2108 PNL----TLrsnpnlmgnqnpnlnlvENNI-------NPnhqnqnqvgDTNFVDTPTN----PTNVQIEMD-VNT---KL 2168 Plasmodium falcipar...

Q8IBD8 2583 VKEKYPISDVWDI 2595 Plasmodium falciparum 3D7
O96294  419 LEQQFPISDVWNI 431  Plasmodium falciparum 3D7
Q9NFB4 1315 LEQQFPISDVWNI 1327 Plasmodium falciparum 3D7
Q8I218 3455 LEPEFPISDVWNI 3467 Plasmodium falciparum 3D7
Q8IAK2 2846 LEPEFPISDVWNI 2858 Plasmodium falciparum 3D7
Q8IBW9 2203 FEEEYPISDIWNI 2215 Plasmodium falciparum 3D7
Q8IIZ5 2170 VKEKYPIADVWDI 2182 Plasmodium falciparum 3D7
Q8IBX0 2052 VKEKYPIADVWDI 2064 Plasmodium falciparum 3D7
Q9U0G6 2197 VKEKYPISDMLDI 2209 Plasmodium falciparum 3D7
Q8IFQ4 2169 VKEKYPIGDVWDI 2181 Plasmodium falciparum 3D7
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