Conserved Protein Domain Family
DUF1180

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pfam06679: DUF1180 
Membrane protein FAM174-like
This entry represents a group of animal membrane proteins, including human Membrane protein FAM174B, which is essential for Golgi structural integrity.
Statistics
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PSSM-Id: 429067
Aligned: 11 rows
Threshold Bit Score: 114.602
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015327856  10 LSRALASALLLs-----------LLLPElsgpsagrpPAARAAPDLQPAARGPRTR------------PPPPP------G 60 
Q8TBP5        10 LSHLLASVLLL------------LLLPElsgplavllQAAEAAPGLGPPDPRPRTL------------PPLPP------G 59  human
XP_003479489  10 LRNLLASALLL-------------LLPAlsrp-vavlRAAEASPGLGPLASGPRTL------------PPLSP------G 57 
Q5FVQ7        10 PCHFLASAFVL------------LLLPAlnqsvvlpsTVPRAVQESKPLEPGPRTL------------SPLPP------G 59  Norway rat
XP_851027     10 VSPLLAAALLLl-----------LLLPPpppg--pggAWASLLRAAAPGPAAPGTS------------PPLRP------G 58 
XP_016286766  12 CRRFLSAALLLalsgqlssllllLLLRDg--------AASDISRPLSPEASLPPSR------------PPLPPla--sgS 69 
XP_002059356   7 NWHLLALVLLLt-----------LFL-----------SHHDQSDAAAPNATSTNANtdprrtvkkdqaPPLPPaqdtavQ 64 
XP_006010435   9 SSCSLAWGLLIp-----------LLLS----------AAAGLSSTLPPAQKMDSSN------------RPSPP------- 48 
XP_015221295   9 FRASLFVCILLp-----------VLL------------------------------------------PPV--------- 26 
Q1RMK9         7 PARLLPLLLLL------------ALLGA---------PAARASRAQSAAPPQPGAErqp-------rpPPGPG------- 51  domestic cattle
XP_003753342   6 PPPPLPLLLLLl-----------VLLAA---------PAVLARRAESASASQPEADhq---------sPPS--------- 47 
XP_015327856  61 SSAARP--AGRAPAlEAAGARGAEGGNGST------PGAGPAaddpggkagaggpAGGVLAVSP------------DPGD 120
Q8TBP5        60 PTPAQQ--PGRGLA-EAAGPRGSEGGNGSN------PVAGLEtddhgg-kagegsVGGGLAVSP------------NPGD 117 human
XP_003479489  58 PTAAQS--PGRAPA-ESPVLRGPEGGNGSS------PGAGLSaddlsg-kageasLGGSLAVSP------------NPGD 115
Q5FVQ7        60 PTAAQP--RGQAQS-EGAGPRGAESRNGSI------PGAASEadgpeg-kagessLGGSLAVSP------------NPSD 117 Norway rat
XP_851027     59 PTAAGS--PGRAPA-DAAGPRGAEGGNGSS------PRAGLAaddsggkareedsAGGSLAVSP------------NPGD 117
XP_016286766  70 ATAAGSglPGSSRT-EFPSGQAGLSGNGSS------PGAGPAe-----------vGGGGLSVSP------------SPRD 119
XP_002059356  65 QTSAESsvPEKVVViSEKSQQAAAQHEHPT------------------------------GVLPeedvhiehsnmnDNTD 114
XP_006010435  49 PVSG----PGNASTkPALHPNSNNHNNNNSnkpmndTRAGSG-------------GGGNLASVPgi---------pGSPE 102
XP_015221295  27 ATVG----PYKAPStKIQVGISQNTGNASSgntkmnTHTGSVgvregknnstgdfQSTSRTVAAel---------aANDS 93 
Q1RMK9        52 --------PGNATGtGSGEAAGGGGSSNSS----------------------------GDALVTri---------sSLLR 86  domestic cattle
XP_003753342  48 --------PGNATQlGSG--MAGGGGSNSS----------------------------VDAVVTri---------sSLLR 80 
XP_015327856 121 KPMT-QRALTVLMVVSGAVLVYFVVRTVRMRRRNRKTRRYGVLDTNIENMELTPL-----EQD-DEEDDNTLFDANHPRR 193
Q8TBP5       118 KPMT-QRALTVLMVVSGAVLVYFVVRTVRMRRRNRKTRRYGVLDTNIENMELTPL-----EQD-DEDDDNTLFDANHPRR 190 human
XP_003479489 116 KPMT-QRALTVLMVVSGAVLVYFVVRTVRMRRRNRKTRRYGVLDTNIENMELTPL-----EQD-DEEDDNTLFDANHPRR 188
Q5FVQ7       118 KPMT-QRALTVLVVVSAAVLVYFVVRTVRMRRRNRKTRRYGVLDTNIENMELTPL-----EQD-DEDDDNTLFDANHPRR 190 Norway rat
XP_851027    118 KPMT-QRALTVLMVVSGAVLVYFVVRTVRMRRRNRKTRRYGVLDTNIENMELTPL-----EQD-DEDDDNTLFDANHPRR 190
XP_016286766 120 KPMT-QRALLVLMVVSAAVLVYFVIRTIRMRRRNRKTRRYGVLDTNLENMELTPL-----EQD-DDDDDTTLFDANHPRR 192
XP_002059356 115 FPDTyAAVFYILVGITSSAILVLVVRVYRL-RLSRAERKYGV-QGDRANQELTPLpmaieDVNsDEEEDHTLFEVN---R 189
XP_006010435 103 RPMT-QRALCVLVIVSAAVIVYFVIRTVRMRRKNRKTRRYGVLDTNIENMELTPL-----EQE-DDDDDNTLFDANHARR 175
XP_015221295  94 RPMSiQRALYVLVAVSALVIVYFVIRTVKM-KKNRKTRRYGVLDTNLA-MEMTPL-----EQDeDEDDDTTLFDARISRR 166
Q1RMK9        87 DLHTlKAAVIVACAFTAFLIACLLLRVFRSGKRLKKTRKYDIITTPAERVEMAPL-----NEEdDEDEDSTVFDIK---Y 158 domestic cattle
XP_003753342  81 DLPTlKATVIVACAFSALLIACLLLRVFRLGKRLKKTRKYDIITTPAERVEMAPL-----NEDeDEDEESAVFDIR---Y 152
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