Conserved Protein Domain Family
UP_IIIa

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cd09970: UP_IIIa 
Uroplakin IIIa
Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.
Statistics
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PSSM-Id: 197379
Aligned: 4 rows
Threshold Bit Score: 335.413
Created: 10-Mar-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001378435   9 PAVDLEPQMAsitFATNNPTLTTITLEKPFCMFNAsnlgnvSYEVNLYVMENSgsvryaviknnrsfpinstfqetaggq 88  gray short-tail...
O75631        17 SAVNLQPQLAsvtFATNNPTLTTVALEKPLCMFDSkealtgTHEVYLYVLVDSaisrnasvqdstntplgstflqteggr 96  human
NP_008884     17 SAVNLQPQLAsvtFATNNPTLTTVALEKPLCMFDSkealtgTHEVYLYVLVDSaisrnasvqdstntplgstflqteggr 96  human
NP_001083096  18 FARSAVPLLAnsdFFSLNPTQTTITLERPFCMFKD------AIDVYLFAIVKGatniqvadaakkvi--asnytgtqggl 89  African clawed ...
XP_001378435  89 raPYKAASFILPQCgdlpnldeagdvskvaeilsaYLVRVGDNGYCSlnpnfkgtCNPPLTRATEYRFKYVLinpssgfv 168 gray short-tail...
O75631        97 tgPYKAVAFDLIPCsdlpsldaigdvskasqilnaYLVRVGANGTCLwdpnfqglCNAPLSAATEYRFKYVLvnmstglv 176 human
NP_008884     97 tgPYKAVAFDLIPCsdlpsldaigdvskasqilnaYLVRVGANGTCLwdpnfqglCNAPLSAATEYRFKYVLvnmstglv 176 human
NP_001083096  90 lgPYQVAKLDNPKCeniqasn-------imadpnkYIVRVGGDVNCLtdpnfkgiCNPPLQNNLQYRFTYVFtigd--vv 160 African clawed ...
XP_001378435 169 edQTLWSQPIRTNQIspyleIDTWPGRRSGAMIVITSILSTLVFFLLVGFAA 220 gray short-tailed opossum
O75631       177 edQTLWSDPIRTNQLtpystIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 228 human
NP_008884    177 edQTLWSDPIRTNQLtpystIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 228 human
NP_001083096 161 qyQTDWSPPISTVNVkssgtIDTWPGRRSGGMIVLTSILSTLMFFVFFAYIV 212 African clawed frog
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