1GXA,1BSO,1EXS,1YUP,4NLI,4R0B,4TLJ,5EED


Conserved Protein Domain Family
lipocalin_beta-LG-like

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cd19416: lipocalin_beta-LG-like 
beta-lactoglobulin and similar proteins
Beta-Lactoglobulin (beta-LG) is the major whey protein of ruminant species and present in the milk of many other species, with a notable exception of human. It is the major allergen of bovine milk. Beta-LG has been shown to bind hydrophobic ligands such as curcumin, vitamin E or fatty acids, or hydrophilic such as vitamin B9. This group also includes human glycodelin (also known as placental protein 14, pregnancy-associated endometrial alpha-2 globulin, and progestagen-associated endometrial protein) which is involved in crucial biological processes such as reproduction and immune reaction. Four glycoforms of glycodelin have been identified in reproductive tissue that differ in glycosylation and biological activity. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
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PSSM-Id: 381191
Aligned: 11 rows
Threshold Bit Score: 200.065
Created: 6-Feb-2006
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:hydrophobic cavity binds different hydrophobic ligands; ligands are bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on Bos taurus beta-LG and on lipocalin/cytosolic fatty-acid binding protein family members with structure
  • Structure:1BSO; Bos taurus beta-LG with bound 12-bromododecanoic acid , contact 4A
  • Citation:PMID 9827560
  • Structure:1GXA: Bos taurus beta-lactoglobulin with bound palmitic acid, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #   #                  #  #  # #       # # # #        # # #        #
1GXA_A      3 VTQTMKGLDIQKVAGTWYSLAMAASDISLLDaqsaPLRVYVEELKPTPEGDLEILLQKWENgECAQKKIIAEKTKIPAVF 82  cattle
1BSO_A      3 VTQTMKGLDIQKVAGTWYSLAMAASDISLLDaqsaPLRVYVEELKPTPEGDLEILLQKWENdECAQKKIIAEKTKIPAVF 82  cattle
1EXS_A      3 VTPIMTELDTQKVAGTWHTVAMAVSDVSLLDakssPLKAYVEGLKPTPEGDLEILLQKRENdKCAQEVLLAKKTDIPAVF 82  pig
1YUP_A      3 VTQTMKDLDVQKVAGTWYSLAMAASDISLLDaqsaPLRVYVEELKPTPGGDLEILLQKWENgKCAQKKIIAEKTEIPAVF 82  reindeer
4NLI_A      3 VTQTMKGLDIQKVAGTWYSLAMAASDISLLDaqsaPLRVYVEELKPTPEGNLEILLQKWENgECAQKKIIAEKTKIPAVF 82  sheep
4R0B_A      2 IPQTKQDLELPKLAGTWHSMAMATNEISLMAtlkaPLRVHITSLLPTPEDNLEIVLHRWENnSCVEKKVLGEKTENPKKF 81  human
4TLJ_A      3 VTQTMKGLDIQKVAGTWYSLAMAASDISLLDaqsaPLRVYVEELKPTPEGNLEILLQKWENgECAQKKIIAEKTKIPAVF 82  goat
5EED_A      3 VTQTMKGLDIQKVAGTWYSLAMAASDISLLDaqsaPLRVYVEELKPTPEGNLEILLQKWENgECAQKKIIAEKTKIPAVF 82  sheep
125916      3 NIRSKNDLGVEKFVGSWYLREAAKTMEFSIP----LFDMDIKEVNLTPEGNLELVLLEKTD-RCVEKKLLLKKTKKPTEF 77  eastern gray kangaroo
P33685      3 VPRTMEDLDLQKVAGTWHSMAMAASDISLLDsetaPLRVYIQELRPTPQDNLEIVLRKWEDgRCAEQKVLAEKTEVPAEF 82  dog
Q29614     21 NIRSKNDLGVEKFVGSWYLREAAKTMEFSIP----LFDMDIKEVNLTPEGNLELVLLEKAD-RCVEKKLLLKKTQKPTEF 95  tammar wallaby
Feature 1      # ##   # # # #        # # #          # # #                                     
1GXA_A     83 KIDAL---NENKVLVLDTDYKKYLLFCMENSaePEQSLACQCLVRTPEvDDEALEKFDKALKALPMHIRLsfnPTQLEEQ 159 cattle
1BSO_A     83 KIDAL---NENKVLVLDTDYKKYLLFCMENSaePEQSLVCQCLVRTPEvDDEALEKFDKALKALPMHIRLsfnPTQLEEQ 159 cattle
1EXS_A     83 KINAL---DENQLFLLDTDYDSHLLLCMENSasPEHSLVCQSLARTLEvDDQIREKFEDALKTLSVPMRIl--PAQLEEQ 157 pig
1YUP_A     83 KIDAL---NENKVLVLDTDYKKYLLFCMENSaePEQSLACQCLVRTPEvDDEAMEKFDKALKALPMHIRLsfnPTQLEEQ 159 reindeer
4NLI_A     83 KIDAL---NENKVLVLDTDYKKYLLFCMENSaePEQSLACQCLVRTPEvDNEALEKFDKALKALPMHIRLafnPTQLEGQ 159 sheep
4R0B_A     82 KINYT---VANEATLLDTDYDNFLFLCLQDTttPIQSMMCQYLARVLVeDDEIMQGFIRAFRPLPRHLWYlldLKQMEEP 158 human
4TLJ_A     83 KIDAL---NENKVLVLDTDYKKYLLFCMENSaePEQSLACQCLVRTPEvDKEALEKFDKALKALPMHIRLafnPTQLEGQ 159 goat
5EED_A     83 KIDAL---NENKVLVLDTDYKKYLLFCMENSaePEQSLACQCLVRTPEvDNEALEKFDKALKALPMHIRLafnPTQLEGQ 159 sheep
125916     78 EIYISs-eSSYTFCVMETDYDSYFLFCLYNIs-DREKMACAHYVRRIE-ENKGMNEFKKILRTLAMPYTVi--EVRTRDM 152 eastern gray kangaroo
P33685     83 KINYV---EENQIFLLDTDYDNYLFFCEMNAdaPQQSLMCQCLARTLEvDNEVMEKFNRALKTLPVHMQLl-nPTQAEEQ 158 dog
Q29614     96 EIYISsesASYTFSVMETDYDSYFLFCLYNIs-DREKMACAHYVRRIE-ENKGMNEFKKILRTLAMPYTVi--EVRTRDM 171 tammar wallaby
Feature 1        
1GXA_A    160 CHI 162 cattle
1BSO_A    160 CHI 162 cattle
1EXS_A    158 CRV 160 pig
1YUP_A    160 CRV 162 reindeer
4NLI_A    160 CHV 162 sheep
4R0B_A    159 CRG 161 human
4TLJ_A    160 CHV 162 goat
5EED_A    160 CHV 162 sheep
125916    153 CHV 155 eastern gray kangaroo
P33685    159 CLI 161 dog
Q29614    172 CHV 174 tammar wallaby

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