Conserved Protein Domain Family
FolK

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COG1634: FolK 
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase MptE (tetrahydrofolate and tetrahydromethanopterin biosynthesis) [Coenzyme transport and metabolism]
Statistics
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PSSM-Id: 441241
Aligned: 96 rows
Threshold Bit Score: 191.226
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013866508   1 MElk--------eWKPIY---DKIMDDFGFNKENDLKSAFILSDIINNt----------KNNIPLDSMee-liKNKDVYV 58 
AAM02289       1 MSd---------pLKGII---EEIRADLGYKESEDLWAASFLCELLRDh----------PRVLRPEDLp----VEEEVVV 54 
EHR75736       1 MEptnmheavdqrLVDIQ---DEVRDAFGWGLEEDLLAAEALVQRTYElvaavpswsqeGRLASLDALratlfAAERVTV 77 
BAJ50762       1 MKtt--------eWLKHY---HEICRILGIDEEKDRIAAETLSNLLKG------------WSASRQELsdllhRGAFAAV 57 
ALI37527       1 MHfn--------nWYPYY---LIIAGLLDIHIQKDFLNSLNLSGLKQI------------GFLGPKCFrk--iQYSKALV 55 
WP_083756410  37 VSps--------lWLELY---EDIRRVMGYSRDGDCYAAKLLSTLLHEaa-------teARYVELREVcrllaSCSTICV 98 
WP_013267132   1 MAra-------evGVRAYr--EIAERMLGYPEVNELNSAMHFDGFISCd----------ELCAKLLEImr-rvSGKEVCV 60 
WP_013336631   7 FDpm--------eWLLVRsyyMALLP--QLNFRGDYLAAELAPSFCNY---------------DGD-Lre--fRWDVVNI 58 
WP_052296942  17 AKpsk------qlILEIL---EAIRASLGFDPLADRRAAVLLETLLYEam-------seERLASIRDIka-ivEGRLVSV 79 
WP_082419582  30 LSpl--------lLGELV---DAIRGFMGYSLREDCRAARILDWLLYEar-------leGRYRSICEVcn-iiRDTHVCI 90 
WP_013866508  59 FGAGPSLKKH-IKILksiied-----ennknDKNFIIISADG-ATKALLEEDI-VPDIIVSDLDGDLNAIFESNERGSVV 130
AAM02289      55 VGAGPSIAEL-PKIVg--------------eLEDSVVYAADG-ACRALLELGI-VPDVVVTDLDGPKEYLLMSSECGSIT 117
EHR75736      78 LGAAATEEEA-RRVA----------------QQEGVIIAADG-SVGALRVRN--RLACVVSDFDGGVH-LHSAAKEGVPI 136
BAJ50762      58 FGAGPSLETD-LKQYlqv-----------fdPERAVTIAVDG-AVRCFLTWGI-LPKIVVTDLDGGDDVLVKAAENGCFM 123
ALI37527      56 IGAGPSIEEStVQNFiieickcgknefstamSENPVVIAADG-ATEMCLDLGI-IPDYVVTDLDGDYESLLRADSGGSIM 133
WP_083756410  99 TGGSESLEKW-VHSLg---------------STCECIVAVDG-STSLLLGYGI-KPDIVIGDLDGSWQATLEAART-AIV 159
WP_013267132  61 VGPLASPDEI---------------------RGCDTIMAPEG-GIISLLEAGL-RPLAVTTDGDSSPQVLYQAVEVSDYV 117
WP_013336631  59 V--MPPAEVKp--------------------SDDGLLIAVEGySVKLLRDWGL-SPDIVVTDFDFSPEEV---INCDCLV 112
WP_052296942  80 VASGACLEKE-ANLI------------------EGVIIAADG-ATSVLLHMGFdCPDIIVTDLDGPLEDILWCAYRGSLI 139
WP_082419582  91 AGGSESLEKR-IRLL----------------HECERVIAVDG-AVALLSSYGV-RPDIIVTDLDGSWFYILEASRAGAVV 151
WP_013866508 131 VVHAHGDNIALIKNYAPKLKN------IIGSSQVpEE-IPYLINYGGF--TDGDRCCFFAEHFGAKRIILCGMDFGEYTT 201
AAM02289     118 VVHAHGDNVTELAELVPTLGR------ILGTCQV-EPpCDLLHNFGGF--TDGDRAVVMAARLGAERVLTVGMDFGNLTT 188
EHR75736     137 VAHSHGDNVQRFTRALSEWSQfdtppsLILTHQTpAQ-CQGAHNFRWLyrRRPSRMLYLAMGVNLMNIDLVGFSLNT-VG 214
BAJ50762     124 VVHAHGDNIEKIRRLVPLMRGr-----VLGTTQT-EP-IGVLENFGGF--TDGDRAVYMCEELGVEKIVVAGMDFDGEIG 194
ALI37527     134 VVHAHGDNFDKIASYVPSLSN------VIGTTQN-FP-LRNVYNFGGF--TDGDRGVSLAVEFLAREILLIGMDFDSRIG 203
WP_083756410 160 VVHGHGDNIAALRYMVPRLPA------VHGTVQC-EP-TPYTSLVPGF--TDGERALGLALLCGVESIHVYGMNVRERVG 229
WP_013267132 118 LLHIHGDNLNRASSLAKEIPRs----kLLLTSQV-YT-PYCVYPSGAF--TDGDRAIAISMEMGASEVKVFGFNFDF-VS 188
WP_013336631 113 LGHAHGDNIAYYPKYASRVRR------LLPTVQV-WP-RGCSLLVPGF--TDGDRAVYLAYYMGAKEIRIYGFNPGKVv- 181
WP_052296942 140 VVHAHGDNAWLLHEIVPRTPL------VAGSVQV-EPlLGLAMLLPGF--TDGDRAAWLAHVAGASKIRLVGWCPDAPQH 210
WP_082419582 152 LVHAHGDNIAALRAVVPRIER------VAGTVQC-MV-SELAYMASGF--TDGDRAFGLAVMCDASKISLYGMNTRERVG 221
WP_013866508 202 KYSrpylkndiEKADGVKIKKLKYAEKLINWLMENGNSE---ILFINNII 248
AAM02289     189 EYSrpgegrgvFRADPVKRKKLAWGERVLRLVERELGVE---VESLTVRR 235
EHR75736     215 MWSa-------TTVPEQKLKKLAWMYRILEMVELHDAVAp---------- 247
BAJ50762     195 QYSkpr--plsEEMEKRKKLKLQIGKNLLETLAAQTTAT---LLDASNTF 239
ALI37527     204 FFSkr-----kVANLKLKKQKLQIGKYLTGMLLENSSAL---VTHITTSN 245
WP_083756410 230 WWSkpwl-nrsVPAWGEKARKLVIAEAVFKAFRVYAERNnirLVW-H--- 274
WP_013267132 189 CVHk-------DYCADTKLQKLRAGREVLLNIASELGYG---VSIKNNLM 228
WP_013336631 182 -----------KRDDEIKRMKLEIARTLINRIMRKAVSNnaaMINLI--- 217
WP_052296942 211 PLSk-------RLVNPLKRRKLVIAEKLLEMLKGYRGEL----------- 242
WP_082419582 222 WWSkpwl-kksIPPWPEKVRKLHIAEGMMRLFTAYALKKgipVEGL---- 266
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