Conserved Protein Domain Family
MPH1

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COG1111: MPH1 
ERCC4-related helicase [Replication, recombination and repair]
Statistics
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PSSM-Id: 440728
Aligned: 82 rows
Threshold Bit Score: 636.773
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ALI35173       1 MIKYRQYQEDIVNRALYN--NSLVVIPTSLGKTIVALLVSLDILlnwKKSKVLVLAPTRPLVFQHFQLFKKNTf-lLDQC 77 
AJF61502       4 dFAPRLYQQTILATASEK--NTLVVLPTGLGKTYIFLMLASLRLkefPDSKILLLGPTKPLVVQYYNVFLRHLeidEKDM 81 
AMD29682       3 SIELREYQKNILESCLRE--NTLVILPTGTGKTIIAFFLIIERLklfPDKKIYFLAPTKPLVTQHYNNFIKFFpdlKDKS 80 
WP_010877027  14 KIEARTYQQLLAADVIRKg-NSMIVAPTALGKTVVAVLVAAERLrkyRGSKVLILSPSKPLAIQHEESFREFMl---aTC 89 
WP_011405626  14 VIEGRLYQQNLAMSVLKKg-NTMIVAPTAMGKTVIAALVSAERLkhyKNSKILILAPSKPLTLQHEHSFKKFLk---aSV 89 
WP_012956887  14 AAEARIYQQVLAANVLKNg-NTMIVAPTALGKTIIAILVAADRLqklKGSKVLILAPSKPLAIQHEENFKHFLn---lPC 89 
WP_013414012  18 KIESRLYQKIIAAKILKNnkNTMIVAPTALGKTVIAILVAAERLhkyKNSRVLILAPSKPLALQHHQKFKEFMi---vPT 94 
WP_013643711  28 KIESRLYQQVLAADVLKKg-NTMIVAPTALGKTIVAALVSAERLktfEDSKVLVLAPSKPLVIQHEESFREFLk---tSV 103
WP_013798537  12 TIEARIYQQVIVASALKK--NTLCVLGTGLGKTAIAALTIAGILs-kKDGKVLIIAPSRPLVEQHYNSMRNFLnidEDKI 88 
WP_088819691  19 GIEARAYQINIIRSIINGg-NTLVVLPTGLGKTLIAVFSIACTLy--DGKKALMLAPTKPLSEQHFNSLRSLLninEDDI 95 
ALI35173      78 IALTGKIGPEIRKTIWKSssFRVYFATPELVKNDIRDGTLNKDEFYLIIFDEAQRAVKDYSYTSISRHFynnsdhgkHPL 157
AJF61502      82 AIFTGNVTPAKREELWKT--SKIIFSTPQGLENDIIANRIRLEEVSLLGFDEAHRAVGNYSYVWIAGQYmrk---akSKR 156
AMD29682      81 IVITGDIQQERRNYLYKQ--GKIIFVTPQTLQNDLISGRITFYDASTIIFDEAHRAVKKYSYTFIAKKFveq---akDYR 155
WP_010877027  90 TSLTGSIKPEERKERWIK--SQIISATPQTVESDILAGRYDLRDVSLIVFDECHRAVGSYSYVFLASNYiqn---arHPL 164
WP_011405626  90 TSLTGNDKPSDRKKLWNE--NQVICATPQTIESDIISKEYNFEDISLLILDECHHAVGSYSYVYLAQKYvqq---akNQL 164
WP_012956887  90 TSITGAVKTDEREKRWDA--SSIICATPQTIESDLLNERYTLDDVSLLVFDECHHAVGSYSYVYLAHRYvke---snNHL 164
WP_013414012  95 SCLTGDIPPKKRVELWEN--SRVICATPQTIESDLIRGNYSLKDVSLVVFDECHRAVGSYSYVYLASKYled---aeNPL 169
WP_013643711 104 SSLTGSIKPEERVKLWNN--SQIICATPQTVESDIISSRYDLKNVSLMVFDECHRGVGSYSYVYLADKYvke---akNPL 178
WP_013798537  89 IVLTGKTPPNKREELWKE--GKIFIATPQIVENDLIAGRLNVDDFVLLIADEAHHTTGNHSYTFVANKFkgk------vh 160
WP_088819691  96 LLLTGKLPIAKRKVLEER--ARIIIATPQTVANDLKSSNLDLDQFGIAIFDEVHRAVGRYAYTYVADKCke-----kNIK 168
ALI35173     158 ILGLSASPGAKEEKIKEICSNLFIEQIIAKSERDDDVLPYIFDTNIEHYSIEMNDYQKDLSALLNSLINDKILWLINNQF 237
AJF61502     157 ILALTASPGSELEKIKEVIKNLHIEDVEIRTDDDPDVAPYVQDVNVKWVHVDLPEHFRSAQKFLSDCFKEKISRMKELv- 235
AMD29682     156 IIGLTASPGWNIERIEEVINNLYIKNIEIRTGEENDIKKYMTGIEIKRIDVELNNELNNIRDLIIKAIDLRISKIKELDP 235
WP_010877027 165 ILGLTASPGADEDKIKTVCENLFMNEVVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLKNRLKMLKNLGV 244
WP_011405626 165 ILGLTASPGWEESKIKEVSHNIYVNEIIIKSEDDADVAPYFNQVQTKWIKVKLTEELKEIKDLLSETLKIRLRTLKKLGI 244
WP_012956887 165 ILGLTASPGHDKSKIKEVCENLFIQDITIKTEDDPDVKPYFNPIQIDWVRVQLGEELEKIRDLVNKALKVRLKGLKSLGV 244
WP_013414012 170 IIGLTASPGSDKEKINEVCKNLSIDDVIIKTEKDKDVSPYFNPIETKWVKVKLDDELIRIKKLMEKSLKRRLKLLKRMDI 249
WP_013643711 179 LLGLTASPGWNEDKIQEVCQNLYIKEVEIKSEEDSDVEPYFNPVEVKWIKTELNQELKDIKMHLEKALKARLTTLKKMGV 258
WP_013798537 161 VLGLTASPGSDMDRILEVCENLGIEHVEIRTEDDEDVKPYIAKVRIIPKRVPLPKEFEESLKLIKDALKERLKVLKESGV 240
WP_088819691 169 ILGLTASPGNSRDKIMELIDTLAIDNIEVRTPEDPDVAPYVKEKNVTKILVEKGETVERISSLLKGLIEEHLYALFHIGL 248
ALI35173     238 IrkRKVESV-YRKDLLSLGDYIKSKLDp-kNMNFFLLRALKVQSLSLILLYCRDLVESQGSFALKKFLD----NAKDNfA 311
AJF61502     236 ---PMNRALdNKTDLLATQRELLVNVKd--SRDYESMKAISLLAEALKVQHALELLESQGITPLLEYMEslvaKAKTT-K 309
AMD29682     236 S---IDISK-GKKDILKWIEEIKKNLEi-rGRDYRLREIVELLSETLKIYHALEVLETQTLYTFISYFKdienDIR---K 307
WP_010877027 245 Id-TIS--V-GKKDLLKARGRVQNRIArstSPPRACYRAISLLASCINVEHALELLETQGIRPLHQYLLrlkeK-----K 315
WP_011405626 245 Id-SIS-KP-SKREILVEQKRLQQKIAsssNPKKEYFTGVSILTEVINIMHSQELLETQSIKTLNNYFNklekK-----K 316
WP_012956887 245 In-TVS--V-TKRDVLKARSRVQRKIGqsvNPPKECFQAISILSAVINLQHSLELLETQGVVPFNDYIKrlrkK-----T 315
WP_013414012 250 Ik-NE--NV-TKKDLLDARKELKKMLTi--DSSRKLYTAISLLVASINIEHALELLETQTINALYKYLErlkkK-----Q 318
WP_013643711 259 Is-SIS-NV-SKKDVLKAKGRAQKRIGvslHPPQKCFLAVSILTAVINIQHSVELLETQGTIPLQKYIErlkkK-----K 330
WP_013798537 241 In-SI--NL-TKTELIELQKEIFA------LDGDEKYELLRIASEALKLFHALEVLETQGRGVFLNYIErlsnQ-----R 305
WP_088819691 249 CpfKKLESI-SKMRILDIGKNIDQL-----KGSNYKFIAIFHYIYVLDLLHAYDLVTTEGIQPFMSYIDsirnKEK---K 319
ALI35173     312 SKTYQELFLDSRVNEIIEKLKDH---NNEpPPKLIKVLSVVSQFldlkediktswsssrdtdtfitkqgnlnykdckdkl 388
AJF61502     310 TKAVKNLVSDLNFKSALITIRNLkemKIE-HPKYYELKSIL-QKygk--------------------------------- 354
AMD29682     308 SKADYEILSDIRIKKAIYLANEYinkNIE-HPKLLKLIEILKEnk----------------------------------- 351
WP_010877027 316 TKAAKGLLADPDFTRAMHLTRRAmmsGVE-HPKLDRLMEILKRElkg--------------------------------- 361
WP_011405626 317 TKAAKSLKNDYKFNKAVLLTRRYkqqDID-HPKMKRLIELLNQIidd--------------------------------- 362
WP_012956887 316 TKAAKNILLDPNFSKAIYFAKEAeekGLE-HPKMNKLVELLKLElgvdeaqtrltslrn-------------dsdssmde 381
WP_013414012 319 TKASRSLVKDIYFRKAISLVERRfmrNQE-HPKLNELIKILKKEia---------------------------------- 363
WP_013643711 331 TKAAKGLLNDAEFQMAVGLADKAvenGVD-HPKLKRLMQILKKElkn--------------------------------- 376
WP_013798537 306 TKSAKSIVNDERIIKVVNNLRQL---DIE-HPKFDKLVEIVEEIlkk--------------------------------- 348
WP_088819691 320 NRSVQSMLKNHVFLKAVGIAETAlknGEE-HPKMKALVQLITEnh----------------------------------- 363
ALI35173     389 vptnyqKKILIFSQYRDTLEEITNFLNY-NCIPCRGFYGQsnkngqRGLSQDKQLSILGDFKMGKFPVLVATSVAEEGLN 467
AJF61502     355 ---ekdAKIIVFSQYRDSISSLVEEINKiPGMKAKMFVGQqkk-kgTGLSQKEQIGLIEQFKSNDFNVLVMSSVGEEGLD 430
AMD29682     352 -----dKKIIVFAQIRKTLDRIKEYCDM-NNIKAEKFVGK------KEMSRSEQIKLLKDFSEGKFNILLSTSVGEEGID 419
WP_010877027 362 ----deARIIVFTQFRDTLEEIYQRCKR-EGINAVKFYGQnsrsgeKGLTQKQQRDIIKSFRMGNHDVLLSTSVAEEGID 436
WP_011405626 363 ---dkkSKVIVFSQFRDTTKSIYENCNK-NNLKALRFYGQasrendKGLSQKKQIETINAFKNEDYNILISTSVAEEGID 438
WP_012956887 382 kvkedsPKIIVFTQFRDTLDMIHERCER-EGIKSVRFFGQgtsdgkKGLTQKEQKKIIKSFKTGNYDVLISTSVAEEGID 460
WP_013414012 364 ----nkNKVIVFTQFRDSVEQIHKKCQE-NNISSVKFYGQrgrdgeKGLSQKEQKEIIKKFKAGVYDVLISTSVAEEGID 438
WP_013643711 377 ----snSRIIIFTQFRDSVENIYQHCME-TNINAVKFYGQasreneKGLTQKKQKEIIKSFKNGEYDVLISTSVAEEGID 451
WP_013798537 349 ---nrdEKIIVFAQYRDTVDKIVRLLNE-RGIKAIRFVGQsnr-egKGMSQKEQIKALEEFKKN-GNVLVSTSVSEEGID 422
WP_088819691 364 ----idNKIIIFAQYRYTISKIVEVLNN-AGLKAMAFVGKk-----EGVTQDQQMQVIKDFRDGKFNILVATSIGEEGLD 433
ALI35173     468 IPNVDLVLFYEPVPSEIRFIQRKGRTGRFSNGKVVILISKNSIDTKYLEISKRKVNRMKSSLQNSN-FI-FEKHDK--RT 543
AJF61502     431 IPEVDVVIFYEPVPSAIRTIQRRGRTGRQKKGDVIVLVAKKTRDEGYRWSSYHKERRMEDILRKLK-KE-FNAEKRt--- 505
AMD29682     420 IPKVDIVVFYEPVPSEIRYIQRRGRTGRGEIGEVIILVTKNTMDERFYWVSIKKEKKMLYIIKRIK-KY-LKINNNieEN 497
WP_010877027 437 IPSVDLVVMYEPVPSEIRMIQRRGRTGRKRKGRMVVLITEKTRDEAYYYSSIRKERSMKENLRGGS-VN-VEVNPI---- 510
WP_011405626 439 IPSVDYVILYEPVPSEIRMIQRKGRTGRKHSGEMFILMTKGTLDESYYWSSQRKEKAMRNNVYNSH-KK-EITLENyvAK 516
WP_012956887 461 IPAVDLVIMYEPVPSEVRMIQRRGRTGRKSSGRMKVLITEKTRDEGYYWTSMRREDKMKTQLATQE-AI-EELKLNavEK 538
WP_013414012 439 IPAVDTVILYEPVPSEIRMIQRRGRTGRKRKGKMIVLISEGTRDEAYYWSSIRKENKMKKQLKRPI-HVkFRKERKh--- 514
WP_013643711 452 IPSVDLVVLYEPVPSEIRMIQRRGRTGRKNRGRMFILITKGTRDESYYWSSINKEKQMKKQLNKNFnKD----------- 520
WP_013798537 423 ISAVNYVIFYEPVPSEIRFIQRRGRAARGEGGIVIILIAKGTVDEIYYRSAIAKEKNMKRILKNMQ-KI-LNKKLK--ER 498
WP_088819691 434 IPSVDTVIFYEPITSSIRSIQRKGRTGRFNVGNIYVLITKDTKDETYFMVSSFREKKMYDMILRIK-KS-LERMPKpaAA 511
ALI35173     544 Fkn----pDKMLESE---Lffly--eksKQyse----------------svNEDNYNENINPILDSISSNSNKKIKSLVK 598
AJF61502     506 ------------EKK---L---------TEf-------------------vLPKTEITIFADYREKSSGVIKKLIELGIK 542
AMD29682     498 Ninn-kmmTESVEKSg-gIfk----------------------------yiTGSQTSQEKDNSSNVINTKSNVPMIIVDY 547
WP_010877027 511 ------------------M--------------------------------EPSGEGPFIYADSREVNSRVLRELKKIGV 540
WP_011405626 517 ------------KED---V---------KVydsnkn----------kidtqEVSDEAEVVIYVDYREKNSNIMRELDKIN 562
WP_012956887 539 Ieve-ksaKDLGKREkviIedprdddssDNfeeea-----------knediEEISLENDNEEKQKELMEKEAKKKQSLED 606
WP_013414012 515 ---------------------------------------------------KNKKEVVIYADSREYNSGVLRELTKLNAK 543
WP_013643711 521 ------------------L---------TDfkpvktk-------tnsedaeKPADENRPIIYADSREGSSRVLRELERLN 566
WP_013798537 499 KetleetrEEQLKEK---Ieen---iqtKEvnetkevkkeenetekdtkksIYPDILELLKIKAKETKEKTLLEKVDDEK 572
WP_088819691 512 ---------KAGQKR---Lf------------------------------------------------------------ 519
ALI35173     599 KLSYRHRSSHDSEQSIPFTKRNLEDLYEVSLNLDRKKLVERVQRQIHDLLGKAGKTGLEVSYLNEVMGIDHEIIGKAIEN 678
AJF61502     543 INLEKLDVGDYVLSPDICVEYKTIPDFIDSLIDKRLFTQLKDMQKYRKQIIILEGDEDIYSQRQLHPNAIRGMLAAITID 622
AMD29682     548 KEKESGVVQTLANTDILIKLENLDVGDYIIGDLIIERKNILDFINSIIDGRLYNQLEKLKDKKSILILEGTEDNFGIDTN 627
WP_010877027 541 DFELKPLAVGDYQISEDTIIERKTTQDFIGSIIDKRLYKQAREMVKNFKRPVMIIEGDDLYSGFINPDAVRGALAAVAVD 620
WP_011405626 563 CEVKVRTMGVGDYQITDDIIIERKTIDDFSKSITDKRLYQQAKELSNNCQKPLMIIEGENIYHTFLHPNAIRGALATIAL 642
WP_012956887 607 SIIEELAKSSTSDELVVYVDSREGNSRVIRALDTIGVKVKVNTMAVADYQVSDDVAIERKTASDFVDSIVDKRLFKQAKA 686
WP_013414012 544 IKIRSLAVADYQVSDEVGIERKTVDDFINSIIDKRLYKQAERLTEEFTRPVLILEGKNLYSRFMNPNAIRGALASIALDF 623
WP_013643711 567 VDIKVKSLAVADYQVSDDVAIERKTNTDFVSSIMDKRLHKQAKELVDNFKKPVIIIEGSEFYSGFIHPNAVRGALASIAV 646
WP_013798537 573 EKEIEKIKVEGAKKIKIIVDVRERHVGRLLADKAKVEFKVLEVGDYIISDRVAVERKTAEDFVNSIIDKRLFMQLKDLRK 652
WP_088819691     --------------------------------------------------------------------------------    
ALI35173     679 LTKMKRTIWLNKNTVALIESIKFISGSKYSVSVEKIVMGKAIVIVNEKWYASLEPRDYFGPRALLKKGNTFDIIGELYRR 758
AJF61502     623 YGVPILATKNSDDTALLMAMIAKREQTEEKKGFTLHSSKPLTLKEQQEYIVSALPGVGPILSKPLLKKFGSVKKIINASE 702
AMD29682     628 ISISYIRTLILKIILEYKIPVIRTSDFLETANYLYLLAKNYNKFPNIPEKVKNYEDLDEVKLEILKSIPGIGENLALKLL 707
WP_010877027 621 FGIPVIPTRSAEDTAAMIRRIAIREQREGRPDMRVRTDKKPLTLREKQLFIVESLPNIGSKYAERLLEAFGSVEGVMNAS 700
WP_011405626 643 DFKIPIIQTQNETDTAFMLKRIALREKDKDNKKPVSIRTQTKPVTLPEQQLFITESLPGIGPVSAKNLLRHFKNVKNIVN 722
WP_012956887 687 MMEEFKKPILILEGDDFYTGFINPNAIRGSMASIAIDYGISIIPTRTPEDTAAMIKRIAIREQQGEKKSIQIRTERKPQN 766
WP_013414012 624 NIPIIPSQSPEDTAAIIYRIAVREQLHEKREIPIRTERKPLTLREKQLYVIESLPHIGAVNAKKLLRKFGSVKNVINASE 703
WP_013643711 647 DFGIPIIPTRSPEDTAAMINRIAIREQTHERSDIQIRTEKKPLTTWEQQIFIVESLPNIGPVTARKLLEEFKTVRGVINA 726
WP_013798537 653 YQKPILIVEGKNFFRLHENAIKGAILSIILDFGIPIIFTENIEETVDILIKLAEKEQIKEKRGVYVRYGKTAMSLKEQQR 732
WP_088819691     --------------------------------------------------------------------------------    
ALI35173     759 AGTLHLIVKKII 770
AJF61502     703 EKLKEVELIGEK 714
AMD29682     708 EKFKSLKNIFLA 719
WP_010877027 701 EKELRSVEGIGA 712
WP_011405626 723 ASKNELKDVEGI 734
WP_012956887 767 LWEQQLFIIESL 778
WP_013414012 704 KELMKVEGIGEK 715
WP_013643711 727 SEEELKKVDGIG 738
WP_013798537 733 FIVESLPDVGPQ 744
WP_088819691     ------------    
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