Conserved Protein Domain Family
HYS2

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COG1311: HYS2 
Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B [Replication, recombination and repair]
Statistics
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PSSM-Id: 440922
Aligned: 76 rows
Threshold Bit Score: 473.167
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_048163902 215 Pk------------------------------------------------------------------------------ 216
AAR39093     109 Tkkp---------------------------------------------------------------------------- 112
BAJ51233       1 Mslqkrqlykelistavsegfqlteralrrleeysnpfqalts------------------------------------- 43 
ALI34834       1 Mtdnsdllkiisfitskgfqihpdalvlienlqvdvyqiveeilmikrerdgskvil---------sddiknilkfstns 71 
AMD29512       1 Mnkddlikllwennifiekkaydllsslkeedfdiifkeaiksninridedfinriigknsnnnkenvekkenninkkqn 80 
CUR52868       1 Mlkeevssaityalskgfqihpdafkilekidvke--------------------------------------------- 35 
WP_084790908   1 Msyatskgyqihpdafamlkgletdvlkavq------------------------------------------------- 31 
WP_048104262   1 ------------------------------------------------------mdeeissavsyalnkgfqihpdalei 26 
WP_048186633   1 ------------------------------------------------------misdigaalnfvinkgfqihpdalki 26 
WP_088820326   1 Medsrikefserlskvkmlpkseinsevignvdldrlvdrli-------------------------------------- 42 
WP_048163902 217 -----------------------------------------ALEME---AKAKVVFDVknvklsppkaknaNGKEGEIVI 252
AAR39093     113 ------------------------------------------edvD---TSIEIIKPI-------------EAKAKKWTV 134
BAJ51233      44 -------aierlkknrpeavvidvedlqqpvekpaesspppasekpihvPRLETISVId------------NDYRIEGDI 104
ALI34834      72 slivndnasngttivnkldhseiidtkknneetilelvtrdFDDFEnnyYVNNIIYDSn------------NSINSGEGV 139
AMD29512      81 kvnikdffnikenkqnvekesnnviliestkkhigeeielsVKEMKe-tKEINILKKF-------------EIQKNKPDI 146
CUR52868      36 --------lqsiikqvvrekakqnmflidqsdlkmfveseiDDRIE---NNHVIMFDPt------------KKVTSAEGI 92 
WP_084790908  32 -------------eiikqkkqtkmivvddiknvvnpgrqeelvPVE---QIAKVLVDPt------------PNVNTGEGV 83 
WP_048104262  27 lhkidvkelgqiikdvvkektkqkqflineedfeiylgikddeEHQ---VEFEILSDPt------------EKITSAEGV 91 
WP_048186633  27 leqidvkeleriikqivkekerqqlylisqkdlesflgikedefIE---DDHEIIYDPt------------PYIASAEGV 91 
WP_088820326  43 -ldigsfvgfhfvtleevtqaigeinnakipmpveviksssFKPIA---SEYHEKFEIen----------rDVEHANGNV 108
WP_048163902 253 KSYELFFKSRLRKMRRILRET-HELR--GVVDIGRLSyt---------------sGYEDEVVIIGLVNSKKETAKG-FTF 313
AAR39093     135 QDFVNFYKNKLDFYKRLLKGR-LNPI--SIRNVLNLK-------------------ENTEVSIIGRVFEIVK-RDNyASL 191
BAJ51233     105 AEFRSYFLSRYHLIKRILSKRrLEFT--PVSEVPAIR-------------------DGGETVVAVMILSKKE-GPGnIKI 162
ALI34834     140 EGYTSLFRSRFDKSLKILSNR-PDSK--RIKKIAFIKqflnqsri--npksqskeNLEESLFIAGLIMEKKIKKNS-YNL 213
AMD29512     147 ISWISYYKQRLDKIKKILREH-SEMR--GIYPLNKIP-------------------ENEEVAIVGLIYDKKITEKG-IIF 203
CUR52868      93 EGFHALFQNRYSKLLKIMMQR-SQSK--KLTPISNVTn----------------gKLDEETYIAGLLMDRRIDRDV-TKL 152
WP_084790908  84 DGYASLFKSRFEKTMRILAQR-PDSK--RMTKISTVKqmgkgagprpaaagerslGSAGTYVVSGLLMSRRTKKNG-IEL 159
WP_048104262  92 EGYGALFASRFNKLRQIMSDR-PESK--KVKDIESVKsv---------------tKNDDELYVWGLVTDRKSDRNI-TKI 152
WP_048186633  92 QGFTALFTSRFNKLKRIMSNR-PEAK--MIKTVSAVLa----------------tKSKDEVYVCGLVTDRRTDRNV-TKI 151
WP_088820326 109 NDFVDYFRDRLHRIRRILETH-VSTDgiPVGNLSLLKd-----------------MVGRDVYITGIVSSKITTKKGnIMV 170
WP_048163902 314 EVEDATGVVRVFIGR-----DKED--YRKSFEVLPDSVVAFSGHYSKR-GLFFANKLFLPDVPLYRrEKPPLEEKVYAAL 385
AAR39093     192 VLEDTTGRVIVKLFP-----DTPA--WEKLKMMVPDDIVGVQGIVGKNa-SIIAKDIIYPDIPTK--QIKRANDDVYALF 261
BAJ51233     163 TCDDPSGQLEVVASKr----NQQL--YKQALELLTDTVVAMRIKRLG--GINILTEIIHPDIDEQQfRRTPQTEEAYICL 234
ALI34834     214 TIDDQSGLLEAFAY------DEDL--KKQISSLILDQMVMIELENNSKrKNHIIKKIFSLDVPDR--IPNRSHSEVYSVL 283
AMD29512     204 VIEDGNNIIKAFVNK-----DNENidFKVVKDIPLDSVIGLVGTYKN--RMFFVNNVILPDVPIRK-PKTFGEDDVYILF 275
CUR52868     153 VIDDPTGSIELLIF------NKEI--QDTANSLQIDQFVMISIASGKNg-GFFVKEILVPDIPDH--IANRSKTETYAVF 221
WP_084790908 160 EVDDYTGRLQVTAM------SEDA--KKQAASLALDQVVMLELENAKGmPGLAIKNVFSPDIPDH--LPNKSRSEAYAVL 229
WP_048104262 153 TVEDPTSSMEIVVF------EGDL--KDAADTLLMDQFAMFKIVPAKNg-GFFAKDIILPDIPEH--TTNRSKTETYAVF 221
WP_048186633 152 TLDDQTGIIETIVI------DEEL--QKTASGLLMDQFVMEKIVASKNg-GFIVKDIILPDIPDH--AANRSKTEAYAVF 220
WP_088820326 171 VMEDETDSVKVIFSNspseiGKRL--YNEASTLVDDEVIAVKGKLIN--QFVIAKQIIWPDVTIT--ERKNVEEDLGIAF 244
WP_048163902 386 ISDIHVGSDQFCEKAFMKFLEWLNGYAGskdeeDILDRLKYIIIAGDVVDGVGIYPGQYNELEIPDIFDQYEALANLLEN 465
AAR39093     262 ITDIHVGSKYFLENHFKKFLDWLNLKKGd---iEIAKKVKYLIITGDLVDGVGIYPEQEKELVITDIEEQYEYFAKLLTE 338
BAJ51233     235 ISDIHVGSKHFRRDYFESFLDWLNRGRDg-----VVKRLTHLVIGGDLVEGVGIYPGQEKDLMYRNVEEQLREAGKLLAE 309
ALI34834     284 ISDLHIGSKFFMEDEFQMFLNWLNGNEEn---kDIVSKIKYICICGDLIDGIGIFPHQDRELFEKDSFSQMEHATNLLAK 360
AMD29512     276 TGDWQIGNKYTFYDLFDRFLKFLNGKTEnekinEIARKIGYIIIIGDVADGVGVYPEQKEELILKTYEDQYKSFEDYILK 355
CUR52868     222 ISDLHVGSKFFMEKEFAEFVSWLSSPD------PIARKVRFVLVGGDIIDGIGIFPNQDKELLLLDVDQQMAKATELLDK 295
WP_084790908 230 ISDLHVGSKYFMQQEFLRFLDWLASGDDd----DVVRKIKFLCIGGDLIDGIGIFPNQDKELLMMNAAAQMAYTTKLLSK 305
WP_048104262 222 LSDLHVGSKFFMEEELSEFIKWISSAD------PIARKIRFVVIGGDLIDGVGVFPGQDKVLDQLTTEDQLQKTFEVLDK 295
WP_048186633 221 VSDLHAGSKYFMEKEFTDMIAWLSSPD------PIAKRVKFVILGGDVVDGIGIYPNQDKELVALNTADQLKLLYDILDK 294
WP_088820326 245 ISDVHVGSKLFLEQNFENMIKWLNGGAQderskEMAGKVKYLVVSGDVVDGIGVYPNQDRDLSVPDMYMQYQMFFDLIED 324
WP_048163902 466 I--PKHIEVFIGPGNHDAARTALPQPGFYDEYAYPLYKlKNVTIISNPAVIDL------HGRKFLVAHGRGIEDIVGVIP 537
AAR39093     339 YlnRDDIKVILIPGNHDAVRLEEPQPPIPRDIAKSLYr-EGFYLLPNPSWVRIhkkddfEGFDLLLYHGYAFDWIISNTE 417
BAJ51233     310 I--PPNIEIVFIPGNHEPVRKALPQPPLQDRYRKLLDEyRRMIHLSNPAELVF------DGRRVTVYHGQGLDDIIQSLP 381
ALI34834     361 I--PKHIKVFMIPGNHDLGRRALPQPAIPRKYADKIYSlNNITMLGNPCMINM------EGVKTLMFHGQSLDDTIATIP 432
AMD29512     356 I--PESIKTIIIPGNHDIPRLAEPQPELPRSLLKESYSmKNIYYLSNPSYVKIh-----NSIVGLLYHGYVLDWLVSNIS 428
CUR52868     296 I--PKHIKVFIIPGNHDPGRRALPQPAIPEKHNMHLWNrENFFMLGNPSMVEL------NGVKILMFHGQSLDDVVGSTP 367
WP_084790908 306 I--PKHIKTFIIPGNHDPGRRALPQPIFPEATSGGLYGlENCTMLGNPAYVEL------NGVKVLMFHGQSLDDVIATTP 377
WP_048104262 296 I--PKHIKVFLISGNHDAGRKALPQPAIPKMYNSELWDrENFFMLGNPSMVSL------NGVKVLMYHGQSIDDVVRTTP 367
WP_048186633 295 I--PKHIKVFIAPGNHDPGRRALPQPAIPAKYCPDLWGrKNFFMIGNPAIISL------NSVKVLIFHGQSVDDIVKTTP 366
WP_088820326 325 I--PDYIHVFVLPGNHDSVRRAEPQPAFPSTIIKDYKk-DNIHFVSNPSYLTL------NGIQVLAYHGTSLDSIISSIP 395
WP_048163902 538 KM----SH----HEPAKPMVELLKLRHLAPTFGGKVPIAPDPEDLLVIEDVPDFVQMGHVHVLDYQIYRGVFLLNSATWQ 609
AAR39093     418 AVm--dGY----LHPEKVMQLLLVKRQLFSGHGSS-PYVPQLPDPFLIDIVPDIFVTGHIHRVGLGEYKGTILLNAGCWQ 490
BAJ51233     382 TT----SYstlpENAAEVVTALLRYRHLAPIYGGSVQLLPSKEDRLVIVEQPNLLQTGHIHVLVNTSYRGVKLVNAAAWQ 457
ALI34834     433 GL----SY----SKPAEAMKILLKSRHLSPIYGQRTPIAPELEDMMVIEDVPDIFHSGHVHVIDVDSYKGTLVVNSGAWQ 504
AMD29512     429 FLrergGY----EKPGELMKFMLMLRLIFTSHGSNPYVPYINEDASVIEIVPDFFHTGHIHRASYDEYRGIDLINSSTFQ 504
CUR52868     368 GL----SY----AQPAKAMRVLLKTRHLSPIYGKRTPIAPELEDMMVIDEVPDIFHSGHIHVVELDMYKGTLIVNSGAWQ 439
WP_084790908 378 GM----SY----QRPAEAMKVLLKARHLSPTYGGRTPVAPESEDMMVMTEIPDIFHAGHVHVTDVDSYRGTLVVNSGAWQ 449
WP_048104262 368 GV----SY----DKPAAVMRHFLRARHMSPIYGSRTPIAPETEDMMVIDDVPDIFHSGHVHFVGLDMYKGVLIVNSGAWQ 439
WP_048186633 367 GL----SY----DKPAKVMQYLLKARHLSPIYGANSPLAPELEDYMVIDEVPDIFHAGHVHVVDLDLYKNILILNSGAWQ 438
WP_088820326 396 GM----SY----DKPEYPMLELLKRRHLSPIYGGNV-IVPSKTDKLVIDKVPDILTMGHVHKNAISKYKGVTIINSGTWQ 466
WP_048163902 610 AQTEFQKMVNIVPTPAKVPIIDVDTARLKt--VVDFSK 645
AAR39093     491 ETTPFQKKVGHVPDPGKAIAINLKTRDKT---ILKFYE 525
BAJ51233     458 DQTDFQRSLGLEPDVGYAAVLNLASMNVE---MKPFAS 492
ALI34834     505 TQTPFQRAMGITPTPGIAIVVNLATLRPY---QINFAN 539
AMD29512     505 DVTPFQRELGHKPEPGILFLRNIKNGEVFginLFNFEI 542
CUR52868     440 SQTPFQASVGISPTPGIAIIVNLATMKVF---TKDFTE 474
WP_084790908 450 AQTKFQQTMGITPSPGIAIVVNLATLQPF---KQDFNL 484
WP_048104262 440 RQTDFQESVGVTPTPGMAIIVNLQTMKVY---QKDFRV 474
WP_048186633 439 SQTPFQSGVGITPTPAVAVLVNLKTFKVY---TKDFTK 473
WP_088820326 467 ARTAFQVKYGQIPTPARMPVFEMKTYKVT---TVNFSS 501
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