4JQ0,4DCK,1Q1U,3HBW


Conserved Protein Domain Family
beta-trefoil_FGF11-like

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cd23309: beta-trefoil_FGF11-like 
FGF domain, beta-trefoil fold, found in the fibroblast growth factor 11 (FGF11)-like family
The FGF11-like family includes FGF11-14. FGF11, also called fibroblast growth factor homologous factor 3 (FHF3), may be involved in nervous system development and function. It plays roles in angiogenesis, tumorigenesis, adipogenesis, or liver regeneration. FGF12, also called fibroblast growth factor homologous factor 1 (FHF1), or myocyte-activating factor, is involved in nervous system development and function. It plays a role in the positive regulation of voltage-gated sodium channel activity. It promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. FGF12 interacts with the C-terminal region of SCN9A. FGF13, also called Fibroblast growth factor homologous factor 2 (FHF2), is a microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, it may participate in the refinement of axons by negatively regulating axonal and leading processes branching. FGF13 plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. It may regulate voltage-gated sodium channels transport and function. It may also play a role in MAPK signaling. It is required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons. FGF13 interacts with SCN1A, SCN5A, and SCN8A. It may also interact with SCN2A and SCN11A. FGF14, also called fibroblast growth factor homologous factor 4 (FH-4), may be involved in nervous system development and function. It interacts with SCN8A. Members in this family contain a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 466995
Aligned: 24 rows
Threshold Bit Score: 228.84
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JQ0_A        72 GIVTRLFSqqGYFLQMHpDGTIDGTKDensdYTLFNLIPVGlRVVAIQGVkASLYVAMNgEGYLYSSDVftpECKFKESV 151 human
1Q1U_A        10 GIVTRLFSqqGYFLQMHpDGTIDGTKDensdYTLFNLIPVGlRVVAIQGVkASLYVAMNgEGYLYSSDVftpECKFKESV 89  human
Q92915        70 GIVTRLYCrqGYYLQMHpDGALDGTKDdstnSTLFNLIPVGlRVVAIQGVkTGLYIAMNgEGYLYPSELftpECKFKESV 149 human
P61328        72 GIVTRLFSqqGYFLQMHpDGTIDGTKDensdYTLFNLIPVGlRVVAIQGVkASLYVAMNgEGYLYSSDVftpECKFKESV 151 human
NP_001071250  71 GIVTRLFSqqGFYLQMQpDGSIDGIKGensdYTLFNLIPVGlRVVAIQGVkAGFYIGMNgEGFLYSSEMftpECKFKESV 150 zebrafish
NP_990219     72 GIVTRLFSqqEYFLQMHpDGTIDGTKDensdYTLFNLIPVGlRVVAIQGVkAGLYVAMNaEGYLYSSDVftpECKFKESV 151 chicken
NP_990108     75 GIVTRLYCrqGYYLQMHpDGSLDGTKDdssnSTLFNLIPVGlRVVAIQGVkTGLYIALNnEGFLYTSELftpECKFKESV 154 chicken
NP_001012382  70 GIVTRLYCrqGYYLQMNpDGSLDGTKDdssnSSLFNLIPVGlRVVAIQSVkTGLYIAMNgEGHLYTSELftpECKFKESV 149 zebrafish
XP_007885222  71 GIVTRLYCrqGFYLQMHpDGAVDGTKDdstnSTLFNLVPVGlRVVAIQGVkSGLYVAMNgEGYLYTSELftpECKFKESV 150 elephant shark
XP_005994553  75 GIVTRLYCrqGYYLQMHpDGSLDGTKDdssnSTLFNLIPVGlRVVAIQGMkTGLYIAMNgEGYLYTSELftaECKFKESV 154 coelacanth
4JQ0_A       152 FENYYVIYSSTLyrqqesgRAWFLGLNkeGQIMKGNRVKktkPSSHFVPK 201 human
1Q1U_A        90 FENYYVIYSSTLyrqqesgRAWFLGLNkeGQIMKGNRVKktkPSSHFVPK 139 human
Q92915       150 FENYYVIYSSMLyrqqesgRAWFLGLNkeGQAMKGNRVKktkPAAHFLPK 199 human
P61328       152 FENYYVIYSSTLyrqqesgRAWFLGLNkeGQIMKGNRVKktkPSSHFVPK 201 human
NP_001071250 151 FENYYVIYSSTMyrqqesgRAWFLGLTkeGQVMKGNRVKktkPSSHFVPR 200 zebrafish
NP_990219    152 FENYYVIYSSTLyrqqesgRAWFLGLNkeGQIMKGNRVKktkPSSHFVPK 201 chicken
NP_990108    155 FENYYVIYSSMLyrqqesgRAWFLGLNkeGQVMKGNRVKktkPAAHFLPK 204 chicken
NP_001012382 150 FENYYVIYSSMLyrqqesgRAWFLGLNkdGQAMKGNRVKktkPAAHFLPK 199 zebrafish
XP_007885222 151 YENYYVIYSSMLyrqqesgRAWYLGFNkeGQIMKGNRVKktkPAAHFLPK 200 elephant shark
XP_005994553 155 FENYYVIYSSMLyrqqesgRAWFLGLNkeGQAMKGNRVKktkPAAHFLPK 204 coelacanth
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