2IHR,1RQ0


Conserved Protein Domain Family
RF-1
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pfam00472: RF-1 
RF-1 domain
This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.
Links
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Statistics
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PSSM-Id: 459823
Aligned: 797 rows
Threshold Bit Score: 36.247
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2IHR_1         216 EEVE--VVLKPEELRI-DVMRASGPGGQGVNTTDSAVRV---VHlPT----------------------Gi-TVTCQTTR 266 Thermus therm...
BAM05053       226 DDGK--LEIDENELEVtAFARSSGPGGQNVNKVASAVRI---VHkPT----------------------Qi-MVVCSVHR 277
Q5QU74           2 IQISqrVELADSEIEW-QFIRSSGAGGQNVNKVATAAQLifdIQ-ASslpdfyksrll-kksdhritqsGkvIIKSQETR 78  Idiomarina lo...
Q8EJF4           2 IKISnrVELPENEIEW-QFIRSSGAGGQNVNKVSTAAQLifdIK-NSslpefyqqrll-qkadhritasGkiIIKCQASR 78  Shewanella on...
Q12J16           2 IKISyqVELADNEIEW-QFVRSSGAGGQHINKVSTAAQLsfdIA-QSslpdfykekll-akadhritksGkiLIKCQQSR 78  Shewanella de...
Q07X45           2 IQITqrVILQDNEIEW-QFVRSSGAGGQHINKVSTAAQLsfdIA-SSslpefyqqkll-ekadhritksGkvIIKCQQSR 78  Shewanella fr...
BAJ03750         2 IKITnrVLLQDNELEW-QFIRSSGAGGQHLNKVSTAAQLifdIR-KSslpelyqqrll-akadhritksGkvIIKCQASR 78 
zuci:PHZ_c0776   2 IEVTpaIQIADEEVQL-RAVRASGPGGQHVNKVSTAIELrfdVR-ASpslpepvrarlyglagsrltmdGvlVLVAQEHR 79 
tigr:AHA_0648    2 LVISnsVTLPWHELQF-QTMRAQGNGGQHVNKTDSAVWLrfdYR-NSpsltplykegl-dklsdsrvhdGfiMIRVETHR 78 
IBRC:GU3_15290   2 LEVSarVQIPEQELEF-ITMRAGGPGGQHVNKTDSAVQLrfdYA-GSpslpehykealakmrdhrvlasGliLIRVESER 79 

2IHR_1         267 SQIKNKELALKILKARL------YELERKKREEELKAlRGevrpiewgsQ-----IRSYVLdK-NYVKDHR 325 Thermus thermophilus
BAM05053       278 KQEQNRKQALGILRAKLelieeeKRQAEMDDatgg-----------kvdRgwgtqIRSYVF-YdNRVKDHR 336
Q5QU74          79 SQARNRELALEQLIDLIrsa---------sqVQKKRIpTKpsr---sakE-----RRLTTKkQqGQKKALR 132 Idiomarina loihiensis
Q8EJF4          79 SQDANRQTALVQFIALVasv---------adVAKKRIpTRatk---ssqT-----KRLDTKkQrGATKAMR 132 Shewanella oneidensis
Q12J16          79 SQDFNRQQALAQFIELVagv---------ahVQKKRVaTKatk---asqK-----RRIEGKkQrGATKAMR 132 Shewanella denitrifica...
Q07X45          79 SQDFNRQTALEQFIELVrsv---------giVQKARIpTKatk---gsqK-----RRIETKkQrGATKAMR 132 Shewanella frigidimari...
BAJ03750        79 SQDSNRQTALAQFIELVasv---------ghTPKKRIaTKptr---gsqR-----RRVDTKkQkGATKALR 132
zuci:PHZ_c0776  80 SQELNRQAAVERLIELVrea--------arPPPPPRKkTRptk---askE-----RRLKAKaQrSGVKSMR 134
tigr:AHA_0648   79 SQDMNRKEAMNRLVELLkka---------awRPKARHaTKptr---ssqR-----KRVDAKkRkGEIKSTR 132
IBRC:GU3_15290  80 SQLMNKEAAKAALVALLqqa---------gkPVKVRRpTKpsk---aakA-----KRADSKtHrGKIKSGR 133
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