Conserved Protein Domain Family
Fuzzy
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cd21091: Fuzzy 
protein fuzzy and homologs
Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.
Links
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Statistics
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PSSM-Id: 411043
Aligned: 13 rows
Threshold Bit Score: 522.677
Created: 23-Dec-2019
Updated: 17-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3UYI6        12 LLCLAASSGVPLFCRSSsggapsrqQLPFSVIGSLNGVHMFGQNLDVq--------------lNSARTEDTTVVWKNfHD 77  Mus musculus
XP_006229121  12 LLCLAASSGVPLFCRSSsggapsrqQLPFSVIGSLNGVHMFGQNLDVq--------------lNSARTEDTTVVWKNfHD 77  Rattus norvegicus
XP_002130176   5 ILCITASGGIPLLTRTKpg----csPLSFPVVGALNGVHMFAANRDVk--------------lLSTLTGNKRIVWKVfQD 66  Ciona intestinalis
XP_027210129   6 LVGLWAPSGVPLFVRHTgh----gkPPPYALIGSLNGVHVFGESHGVt--------------lCTTRTQNASLTWKTyHD 67  Penaeus vannamei
XP_011405750   6 LAVIISSTGVPLFIRTKgd----vpQLSFPVVGSLNGVHWFTENAKAs--------------lLSCTSKNVRIVWKNfHD 67  Amphimedon quee...
NP_079405     12 LLCLAASSGVPLFCRSSrggaparqQLPFSVIGSLNGVHMFGQNLEVq--------------lSSARTENTTVVWKSfHD 77  Homo sapiens
XP_005280837  10 LLCLTASSGVPLFCRSMgap--skhQLPFSVIGSLNGVHMFGANLDVl--------------lTAACTTNTHVVWRVfHN 73  Chrysemys picta...
XP_018418947   8 LLCLTATSGVPLYCRSKss----srQLTFSVIGSLNGVHMFANNQDVl--------------lTSTRTENSRVLWRTfHD 69  Nanorana parkeri
XP_014341041  17 LLCLTASSGVPLYCRSRgts---qkQLPFPVIGSLNGVHMFGSNQDVl--------------lTTTCTENARVAWRVfHS 79  Latimeria chalu...
Q2HZX7         8 LLCLAASSGVPLYSRSKgs----srQLTFSVIGSLNGVHMFASNQDVl--------------lTSTCTENTRVAWRAfHD 69  tropical clawed...
XP_028660119  10 LLCLTASSGVPLFCRGRga----crQLPFSVIGSLNGVHMFGSSQDAq--------------lSSTVTEWGRVLWRVyHE 71  Erpetoichthys c...
O16868         5 LLCLTTNGGLPVFTRKKge----ceNLPFSTVASLNGFHMFFKSLGIqleatttskqqpiqnqAPADAEEWTYIWRD-RE 79  fruit fly
Q9BT04        12 LLCLAASSGVPLFCRSSrggaparqQLPFSVIGSLNGVHMFGQNLEVq--------------lSSARTENTTVVWKSfHD 77  human

Q3UYI6        78 SITLIVLSSEEGTSELrl-------------------------------erMLHMVFGAMVLIVG-LEELTNIRNVERLK 125 Mus musculus
XP_006229121  78 SITLIALSSEEGTSELkl-------------------------------erMLHMVFGAMVLIVG-LEELTNIRNVERLK 125 Rattus norvegicus
XP_002130176  67 SIVLIAIVPSLDAKMCgksnpddeeeqdaafilqdssrnssstitdahisrLLENVFHSLVFLTG-LQELTNIQNVDRLK 145 Ciona intestinalis
XP_027210129  68 SIRLVLVRGSETTGDSsd-------------------------------ssLLDLMFASLVLLLG-LDTVTSSTNIERLK 115 Penaeus vannamei
XP_011405750  68 CLTLILVSTNDSPTDThc-------------------------------nyLSTLIFNAMVLLIG-LPDLLRIEDPENLK 115 Amphimedon quee...
NP_079405     78 SITLIVLSSEVGISELrl-------------------------------erLLQMVFGAMVLLVG-LEELTNIRNVERLK 125 Homo sapiens
XP_005280837  74 SITLIVLSSEEGVSDFal-------------------------------grLLDNAFSAMVLILG-LEELVNVRNIERLK 121 Chrysemys picta...
XP_018418947  70 SINLIVMSCDMKTSDHsl-------------------------------nkLLENVFSAMVLVIG-LEDLMNIKNVERLK 117 Nanorana parkeri
XP_014341041  80 SITLIVLTSDDCASDLyl-------------------------------grLLENVFNAMVLVVG-LDDLINIKNVERLK 127 Latimeria chalu...
Q2HZX7        70 SITLIVMSSESGASKLsl-------------------------------nrLLENVFNAMVLVIG-LDDLVNIKNVERLK 117 tropical clawed...
XP_028660119  72 SITLIAVSSEEGASELyl-------------------------------erLLENVFSCMVLILG-LDDLANIKNVERLK 119 Erpetoichthys c...
O16868        80 SITLIVCGCGVGSEQLlq--------------------------------tLADLVFGAIGMFITrAAEMAHATLLDRLK 127 fruit fly
Q9BT04        78 SITLIVLSSEVGISELrl-------------------------------erLLQMVFGAMVLLVG-LEELTNIRNVERLK 125 human

Q3UYI6       126 KELRASYCLIDSFLGNS--------ELIGDLTQCVDCVIPPEGSAMQETLSGFAEATGTAFVSLLVSGRVVAATEGWWRL 197 Mus musculus
XP_006229121 126 KELRASYCLIDSFLGNS--------ELIGDLTQCVDCVIPPEGSVMQETLSGFAEATGTAFVSLLVSGRVVAATDGWWRL 197 Rattus norvegicus
XP_002130176 146 KDLRSCNSLIDTYLDTSekqkqpqfEMFGDLTQCVDVMLHEDSKLLEEHLTAFAEAADSTYGCLVNNGQVVCATAKWWLL 225 Ciona intestinalis
XP_027210129 116 RDIRPCFPLLDELLFRAvgg--enhQGFSHLTGCAECVIPPEHHALQNEIEKFAESADSTYACVMMEGQVVSGTRNFWTL 193 Penaeus vannamei
XP_011405750 116 RDLRCCYPLIDLLLGNQ--------FTMSPLTQTVEVLVDHEHKSLMDGLGSLSEAIESNYSCLIVNHQIIHATESWWQL 187 Amphimedon quee...
NP_079405    126 KDLRASYCLIDSFLGDS--------ELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVSGRVVAATEGWWRL 197 Homo sapiens
XP_005280837 122 KDLRACYKLIDSFLAPL--------ERSGDLTQCVECVPVPHGAALQECLEAFVAAAESRFGCLVAGGRLALATEPWWQL 193 Chrysemys picta...
XP_018418947 118 KELRACYKLIDSFLTES--------EKMGDLTQCVDCVIAHDAAILQECLDGFTQAAESEFGCLLTGGKVVVATEKWWRL 189 Nanorana parkeri
XP_014341041 128 RDLRASYQLIDSFLEVS--------EMVGDLVQCVDCVLSNNNGVLQSCLDAFTQAAESQFGCLLVRGKVVVATEKWWRL 199 Latimeria chalu...
Q2HZX7       118 KDLRACYRLIDSFLLET--------EKMGDLTQCVDCVIAYDVPILQECLDNFTQAAESNFGCLMAGGKVVVATEKWWRL 189 tropical clawed...
XP_028660119 120 RDLRSCYKLIDSFLEVPn-------EDVGDLTHCADCLIPQEPTILQECLDGFSQAAESEFGCLLVDGKIVVATEKWWRL 192 Erpetoichthys c...
O16868       128 KDAKKYVPIVDAILEAA--------CAGTQLLGYTDCLLAAENAQLLQCLNEFSGHCGSLFCCLVVGHRIAVATEGWWDL 199 fruit fly
Q9BT04       126 KDLRASYCLIDSFLGDS--------ELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVSGRVVAATEGWWRL 197 human

Q3UYI6       198 GMPEAVLLPWLVGSLPPQaa-rDYPVYLPHGSPTVPHRLLTLTLLRGL------ELCLLCGPRPPLGQLDPQlmERWWQP 270 Mus musculus
XP_006229121 198 GMPEAVLLPWLVGSLPPQaa-rDYPVYLPHGSPTVPHRLLTLTLLRGL------ELCLLCGPRPPLGELDPQllERWWQP 270 Rattus norvegicus
XP_002130176 226 TGLELALLSRLINTLSSSitscDIPIYLPHSSPNIAHRLLVFTLVSGVgvksgvRVCVLCGPQPSLTQVQETllESFWRS 305 Ciona intestinalis
XP_027210129 194 SHTELVLLPLLVTTNTFTva-rDLPIYLPNKSPNVPFRMLVVQLTSHV------SVVTLCGPTPSLADMIRSa-TSFWAP 265 Penaeus vannamei
XP_011405750 188 DVIDSNLLTLLPSSLPPTqc-tDVPVYLPVASNTSPHRLLVFRLYDSV------SLLVLCDTEPSLDVAQKIv-VQIWLP 259 Amphimedon quee...
NP_079405    198 GTPEAVLLPWLVGSLPPQta-rDYPVYLPHGSPTVPHRLLTLTLLPSL------ELCLLCGPSPPLSQLYPQllERWWQP 270 Homo sapiens
XP_005280837 194 APQELLLLSWLVGSLPPHaa-rDYPIYLPHGSPTVPHRLLTCQLLPGL------EACLICGPSPALHTVETElvPRFWKA 266 Chrysemys picta...
XP_018418947 190 ASQDVMLLCWLVSSLSTHss-rDYPVYLPQGSPTVPHRLLTFQLVPGV------DVCILCGPSPSLQKVQSElvERFWKP 262 Nanorana parkeri
XP_014341041 200 SAQEVMLLAWLVASLAPCss-rDYPIYLPQGSPTVPHRFLSFQLLPGV------DVCVLCGPTPSLQEVENElvERFWKP 272 Latimeria chalu...
Q2HZX7       190 SSQEVMLLCWLVASLAPHss-rDYPVYLPQGSPTVPHRLLTFQLVPGV------DVCVLCGPKPSLQKVETEliERFWKP 262 tropical clawed...
XP_028660119 193 APQEVVLLSFLVRSLGGSss-rDYPVFLPQGSPNVPHRLLCFQLLAGV------DVCVLCGPTPSLQKVERElvCRFWSP 265 Erpetoichthys c...
O16868       200 DTRDRELLLFLLNSSSTMq--hDVPVYLPVKSPHIAYRFVSIPVASNS------ALCVLCGAENASFRELHAhaMSAYRN 271 fruit fly
Q9BT04       198 GTPEAVLLPWLVGSLPPQta-rDYPVYLPHGSPTVPHRLLTLTLLPSL------ELCLLCGPSPPLSQLYPQllERWWQP 270 human

Q3UYI6       271 LLEPlRACLPLGP--RALPEGFPLHSDILGLLLLHLELRRCLFTMEPSKDK-------------EPSPEQRRR------- 328 Mus musculus
XP_006229121 271 LLEPlRACLPLGP--RALPDGFPLHSDILGLLLLHLELRRCLFTVEPSKDK-------------EPSPEQRRR------- 328 Rattus norvegicus
XP_002130176 306 AMNTlQRCAHSHT--IPDPLIQTLPSPLLGFLLIDTENRRCVSLMRPSSGDad---------hmSRRKQQKNEekfessw 374 Ciona intestinalis
XP_027210129 266 FYQVlEALSSLLPwnIAPALLAQLDNSVIGLLLVNYDHKRCVGCLHLSEDSrs----------rSLCVNKKSA------- 328 Penaeus vannamei
XP_011405750 260 LRDKiISLPLLVP--RAFPLSVTMDSSVIGFCFVNLLTRRSLLSVLSYETQernpallskgyqgALDDNKKRD------- 330 Amphimedon quee...
NP_079405    271 LLDPlRACLPLGP--RALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDK-------------EPSPEQRRR------- 328 Homo sapiens
XP_005280837 267 LLEPlQACVSPQP--HGLPPGTALPPGVLAFLLIHREQRSSQSSVQPPGSGg-----------eGLSPKRRAR------- 326 Chrysemys picta...
XP_018418947 263 VLDPiKSCLRVQL--RSFPASVPLHHGIQGILLVNRDLNKSLYTVQVHPMEdmqr------sdmKCILEQRRE------- 327 Nanorana parkeri
XP_014341041 273 LLEPlKDCLRIQA--RAFPGCISLHQGIMGLLLINREQKKSLYTVQPHAGEarp--------esTLSAEERQS------- 335 Latimeria chalu...
Q2HZX7       263 VHDPiKSCLRVQM--RSFPASVPLHHGILGLLLINRDMNKSLYTVQAHPMEemqk------tdlKLTLEQRRS------- 327 tropical clawed...
XP_028660119 266 LIDClRICVRLKG--RCFPGTVSIPQGILGLLLINRDNSRALCSIQGFQESaqs--------saSFSQERRRE------- 328 Erpetoichthys c...
O16868       272 EGNLlAAAERCVP--RSLPEHLEIDGNVLAIILINRHTRKSLFTRNLNQSAsvk--------riIVGDLQRLD------- 334 fruit fly
Q9BT04       271 LLDPlRACLPLGP--RALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDK-------------EPSPEQRRR------- 328 human

Q3UYI6       329 ---LLRNFYTLVATTHf---pPEPGPAEKQEDTVyp-------------------------------aqMPRACYLVLGp 371 Mus musculus
XP_006229121 329 ---LLRNFYTLVATTHf---pPEPGPAEKQEDTVhp-------------------------------aqTPRACYLVLGp 371 Rattus norvegicus
XP_002130176 375 ifgKLTEFYKFVVGTSlp--lPETIEDEPYPDTIhds------------------------------shIGLCHYRCLKr 422 Ciona intestinalis
XP_027210129 329 ---ALQSVYRSIIGPLl---qPPAMPPEDFPTGLhp-------------------------------dhLPLESYVSTDs 371 Penaeus vannamei
XP_011405750 331 ---YLIQFYKTVADNLlpihaPATASDKNTTPTHapptnedndelggvknnnnndsynlvpltkdriphKIIETYSCTKg 407 Amphimedon quee...
NP_079405    329 ---LLRNFYTLVTSTHf---pPEPGPPEKTEDEVyq-------------------------------aqLPRACYLVLGt 371 Homo sapiens
XP_005280837 327 ---ALRHFYALVATRYf---pWEGSPAPAQEPFQagf------------------------------phRARHCYVVSAt 370 Chrysemys picta...
XP_018418947 328 ---ALRSFYALAMSRYf---hPEHHDGKNTVQYEesfpm--------------------------gfshHAHQCYTVSSs 375 Nanorana parkeri
XP_014341041 336 ---VLRSFYTLAVSRYf---vSEDGEDKSMSTQEefqa---------------------------gfshRGKECYVVSSd 382 Latimeria chalu...
Q2HZX7       328 ---ALRSFYTLAMSRYf---pSERADGKNTLPSEesfqs--------------------------gfshSAHQCYTISSs 375 tropical clawed...
XP_028660119 329 ---LLRQFYTLATTRYf---lAEPQGEKHRALTEefqf---------------------------gfthEPVQCYLVTDd 375 Erpetoichthys c...
O16868       335 ---ILKKFFDQTMDAVh---qFETQSSSNKTTLV-----------------------------------DQYSCSDYHK- 372 fruit fly
Q9BT04       329 ---LLRNFYTLVTSTHf---pPEPGPPEKTEDEVyq-------------------------------aqLPRACYLVLGt 371 human

Q3UYI6       372 gm---gwQLVAVQLGLRLLLLLLSPHTPTHGLRSLATRTLQALTP 413 Mus musculus
XP_006229121 372 gm---gwQLVAVQLGLRLLLLMLSPQTPTHGLRSLATHTLQALTP 413 Rattus norvegicus
XP_002130176 423 ------hKAFALVRSQYQLFAVYSNTAPTFALQGLTNQAMDVLLK 461 Ciona intestinalis
XP_027210129 372 ------yKVYVLQSSPFHLLVLFPPALPIHIARQVSKRTLAIFTK 410 Penaeus vannamei
XP_011405750 408 ------fKGYAINNFQYNIFLLFDVNTPTYALREISHDTLQSLVA 446 Amphimedon queenslandica
NP_079405    372 eepgtgvRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTP 416 Homo sapiens
XP_005280837 371 ------hKAYAIHAPQHQLFLLLAPHVPTFALRPLATRTLQRLTG 409 Chrysemys picta bellii
XP_018418947 376 ------nKCYAMKTDLHFLFLLFKTDVPTFSMRAIANKTMQVFTK 414 Nanorana parkeri
XP_014341041 383 ------hKCYGIQHEQHQLFLLFKPEVPTFALRNITTKTLVVFTK 421 Latimeria chalumnae
Q2HZX7       376 ------cKCYGMKTELHLLFLLLKPEVPTFSMRSIANKTIAAFTK 414 tropical clawed frog
XP_028660119 376 ------cKCFGIQTPQYQCFVLTTDSVPTFALRSLATRTLTALTT 414 Erpetoichthys calabaricus
O16868       373 -------CYAHMDELGNVIFLLFVAAVPSHAMRFLAQRIHANILQ 410 fruit fly
Q9BT04       372 eepgtgvRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTP 416 human
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