Conserved Protein Domain Family
Tti2

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pfam10521: Tti2 
Tti2 family
Budding yeast Tti2 is a subunit of the ASTRA complex, which is involved in chromatin remodelling. Tti2 homolog from humans, TELO2-interacting protein 2, is part of the TTT complex that is involved in the cellular resistance to DNA damage stresses.
Statistics
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PSSM-Id: 431336
Aligned: 63 rows
Threshold Bit Score: 148.192
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDN09340     153 VITSIAAFTCRLDPWTTEQAFDDASTI--LQNyesflrsnRREEELTAVLENILRKKVKPLFSKtk-------------t 217
Q6CWH6        48 GLVSLSYFLLNE-HWTRYEQRDRVTHL--IDNyl----------dRDHDLVHSFISALKPMLIKstginndnltpsgrrk 114 Kluyveromyces l...
CCK69106      48 LIQQLSCFALDQd------aKKAQCVIkfVNT--------LWDATDGDPLYVDLIPLLKPHLLLnlgdgs------sakr 107
CCF58588      51 AIKALSYFTMDPd------mKVRKIAIstMEElc----------aKDSNLLPQLIDDVRNSLQKlgh------------r 102
EEQ38378      89 LLCLIGAYINPHVKWSNLELANIASSL---------------SVDEISVHMSQFFDFLKPRFLSmr-------------n 140
EGW31884      93 LIYTLSLHSNPNVPWCNNINSQIVTSIi------------TEINMPNEIIEDFIENEYKRNIQQvk-------------- 146
EAZ63225     127 IMRLLACYTNPNLPWTSEITEKIVGSV-----------------DVEDMMEELIETELKPNLLV---------------- 173
Q6BN22       148 LLAPLSYHMHPKLPWTSELNSKTIENFiaDNN--------KVRDMIHSVIPLYIDKKLKPELLNlsstkgqy-irnslsn 218 Debaryomyces ha...
XP_001483237  44 TIEAISQHANPYLSWCSSEGAALVMEI-------------VDSSCSGKNIDDFVEEKVVPRMQTlps------------s 98 
XP_004204156 140 LLSSISYHIHPSLPWTCSKNANIIHKI--LENf-------SKSASFESAMDTLFNGELKASLLVlsskhvpsqrdkslhn 210
EDN09340     218 pAVTAAGRKNVHpipq--------------prfDPSIFDPES--KPWK-FRYVYIITVLSWVIERYSPSdkfSLESQFPL 280
Q6CWH6       115 iESSRPGLQPRL---------------------GFEQTFGESrwKEWRtNGGLRSIGLFYIILRHLGKQ---EISANLPW 170 Kluyveromyces l...
CCK69106     108 rNRVAPGLNPVL---------------------GVSSQEDEIr-SRWKsQGGWKHVGLFYIVLLHLQHR---DVSVELRW 162
CCF58588     103 gKDEQNGLKPQL---------------------GLALKGDKIm-SDWKsQGGLKDIPIFNTILLNLPRN---QISENLWW 157
EEQ38378     141 sKVTSAGYKRDEspiprglr-----pklglsssYEQNTR-----DTWKrSDDVKALSWVVLLMKVGRRWsg--fDHSWPV 208
EGW31884     147 sERSSSGlrprl----------------gfnsvASEISSSE---QIEKlKAYPISLSQAWFLIEISTDKhr-wcSQVFNL 206
EAZ63225     174 -LPKVAGKKALQgglnpr---------lgyggaKREILEEDAr-RNWKsGTKVKALSVAYFIIKLAPSTfw--sAGNWRV 240
Q6BN22       219 pKTTPAGYAIGNsgstrllqgg-lrpklgyggtRTEVIAEDQr-QAWKsSTKVKSISMIWFVIYTITSNeh--lNQFWPL 294 Debaryomyces ha...
XP_001483237  99 qKTTSAGYAAKRtlgglkp-------rlgftqsEQELSIPETt------------YSMIYFCISCQHKGtw--ySSRWSL 157
XP_004204156 211 pRLTSAGYASTLlkkkdingksalrpslgfsgvNEEINESDQr-RLWKmSSHVKVLSMIYLMIYFSGDFsr--iEDNWAF 287
EDN09340     281 LVPAILSLIDDEN---LSFKAKGCELLLKFLSPLEQSns---dVLQRTNLDSVFQEALYPCLLSIPTITPEAESIHLLQY 354
Q6CWH6       171 ISPGILNIIDDTTlgpENVRVYGIMLLCTLLESVLNKrdtynfNFKDTGLQKVYEPILTNLLYNLPPSSTPEETLRTWKV 250 Kluyveromyces l...
CCK69106     163 ITPGILNLLDDPHd--IPLRVQGVQLVHAFVEVFRDPeh--wvPFSSTGLFLLFEPVLKNMCYLVPTLYSTMDTTRVWRS 238
CCF58588     158 IRPGILSLLDDTTd-lRGIKLNGVKLLGTLVDRCFIDvsdkwiSFKETGLFDLTEPMVRNLCYYLPPTYSMEDSISVFEA 236
EEQ38378     209 ITTFIINVLDDSD---AYYREQGCHLLNIFLSCELGD------LLLKSGMVHVFQEALETSLNFLPSLTPAEKSLSLLSA 279
EGW31884     207 TISFILNLLDLSD---IEIKTHACQLLQFLLSKSSH-------FKFNSGLIKEVSKSLSKCLVYIPPSVSVDRSLPILSQ 276
EAZ63225     241 ISSFILNVGDDHD---PLFKYQSVKLLALMTERLEQLdh--idVIRSSGLIDVLSESVRKCLVYYPSTTTVNTSLLLLDA 315
Q6BN22       295 ITSFILNLIDDHD---PLMKAQSCELLNYFMLMIDHSkdykqhILLKTGLVDLLIESCKTCLTYLPNLTPSDQSFYLLSI 371 Debaryomyces ha...
XP_001483237 158 VTSFILKVLDDPS---AVIKIQGCRLLDHFLLFPQATs-----LLDRTGLRDLFSDSTKVCLSYLPGMTPLDQSLPLLDI 229
XP_004204156 288 ITSFILNVLDDHD---PLIKAQGCYLLHYLILHWRGKggs-snLLLKTGLCDLFKSSIGVCLTYLPNLTPLDQSIFILKL 363
EDN09340     355 AYPALFAVIRTRFSspkvPSAPtllrpyqtkmkhdpdsqkRLESLTRLLRHGILH------SYHHtsnprpientsiSSY 428
Q6CWH6       251 TYPALQLILRVEAS----DNDQd-----------------FRDRLGHMFSENILQltipriGLDY--------------- 294 Kluyveromyces l...
CCK69106     239 VFPALIALYRVEFS----DTLE------------------YFRHLQSMCSEIVLRgliprlGVKY--------------- 281
CCF58588     237 VIPTLRCLYKAQYD----IKDC------------------KDMIGAKILSQILLQhvipriGIRY--------------- 279
EEQ38378     280 TYPTLYSLQHLKKA--------------------------SPMEFVGILDKHILG------SISHvqg-------rhNDA 320
EGW31884     277 AYPCLIEVYSTYG---------------------------TNLDYVELIST-IIS------NVNHll--------tsEVE 314
EAZ63225     316 SYPLLFKLFDISGT--------------------------DWTEIMDVISSNIMG------AISHlig-------tvEAS 356
Q6BN22       372 AYPTVVKLCVLNCK----KEA-------------------NFLSLVELINGNILS------SATHihn-------snGPN 415 Debaryomyces ha...
XP_001483237 230 AYVVMFKLEGKNVH--------------------------KMLDMLSGILRAILS------KINEp----------eIQN 267
XP_004204156 364 AYPTYYSLLQLEQD----KES-------------------KLLSYLDTINSHILT------SISHvfn-------tkGYI 407
EDN09340     429 PyPRLSALLL-SQLPPALSE-LGIHTTKHLQDLVPTISA-ALSNPFGTA 474
Q6CWH6       295 --PGLSLWIL-GYCQDVVLM-LGKETTLYLQRVIYVLGEfYFRNAFMTL 339 Kluyveromyces lactis
CCK69106     282 --PTLTVQLL-TTLSELLSK-MGPLSVVLLQRTVYTLGEcIVSDPFFTV 326
CCF58588     280 --EKLSELVIsDIMCPMIRS-LGETCVPYLQRIIFTVGEyLVRDPFITT 325
EEQ38378     321 KtNSVLRFLL-SQIAIIVTDyIGPSVLGCLSRLIFVLNQ-LIVNPFVID 367
EGW31884     315 ItEPVLVLLL-DQVLVMSEK-LDTDITICLSKLLYTLNQ-VIVNINICE 360
EAZ63225     357 SgFPVVCFLL-DQLSEIVATsIKTKILISISRLFFMLNS-IITN-ITVL 402
Q6BN22       416 SnYPLLSLLF-NQLDIIIKYyLKTNVLICLSRLNFTINQ-VMSNPDIFE 462 Debaryomyces hansenii
XP_001483237 268 SqYKLPILLL-QKLKKCLGT-LEHRFVASLSRVNYTLNQ-VIVNPGATE 313
XP_004204156 408 SsYSLVTFLF-EQLQIVIGDyMRDFVLTCYDRIHKLIYQ-LLINLDIQE 454
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