1ZHI


Conserved Protein Domain Family
Sir1
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pfam11603: Sir1 
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Sir1, ORC-binding domain
This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
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Statistics
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PSSM-Id: 431955
Aligned: 35 rows
Threshold Bit Score: 88.0575
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1ZHI_B         16 YVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKD-HQRAMIDQMNLVKWNDFKK---YQDPIPLKAKTLFKFCKQIKKK 91   baker's yeast
XP_003674470  298 AISERYTVVDKYVVDTQERKL--IDPEVLRRSGTD-EEKDQLSNYTLLDWNVLKL---SKYPYGSDAEELFDILNAPSED 371 
XP_003671428  296 KISDSLMVTGGFLVDIIEKKIINPNEQDYLRNLTD-EEKEYIEECDLVDWNILKL---TKHPYAVDSPQLFDTLNANNED 371 
CCF59789        4 IISERYCVIEGWIVDQVDR--IIVPKSKIVKNLVP-KKLELLNRQFLIDFKNVDLs--QSVIYEYTSQELHDLIDKEFYE 78  
CCK69126        4 QITDDIVVIDRWIVSIPDRKV--VSSFAAKRQLSQ-ANYRKLVAIEPVDLTRF-----TTTFHTVDSPELFQHIDLHPHE 75  
XP_003959754    6 YITNNIAIIDGWIVDTSKN--FVLTMYNCKQQLDS-YVFTKLNQHVLQNYKSLANp--KNQIFAVESEMLFQHAKLEAHR 80  
P21691          3 QINSRLAVIDGWLVDTVKRKPINFRSPEVRLLLPNdDDYKKLSQQNLVDWTRLKKd-sNSVLVGVKSMELFKHIKLVLRE 81   Saccharomyces...
XP_003672439    3 KLNSRYVAIDGWLVDIDQKRI--INPEDIADDLPN-EDYFKLSQLHLKNWEEVSDe--PQLFISTKSQLLVEKIRWRLQD 77  
XP_003678548    3 SLNDQYSIIDGWLVDFINKCVVDPLHQSIKSSFRD-GNYNELLKHKFVHFRDLEDa--KTILIGIDSKQLFEHVQQRMYI 79  
XP_003670063    3 MLNTRYTFINGWIVDLENGKIINPDLKTYK------PLKKLLGDLQYWNWDEYFKqsdHCQLYCDDSSVLFGLIEMEDYN 76   Naumovozyma d...

1ZHI_B         92 FLRGADFKLHTLPtEa-----nLKYEPERMTVLASCVPILLDDQTVQYLY 136  baker's yeast
XP_003674470  372 FYEDIKGNISTNReM-------LDQKGKIKTVPHRSVSIYFEEFGWKHIY 414 
XP_003671428  372 FYEDKNGDLWIVPp--------TEYKGALTPRKYRSIPLHFKSFGWRHIY 413 
CCF59789       79 FSELLDGRIINKDgRiy----qRSKTKIKRTFTKRCHRVSIHGRQYVYLL 124 
CCK69126       76 FAVLPNGDAVPRSsVay----rRADKSKCNLFTRMSHRVSTGGRRVVYLV 121 
XP_003959754   81 FYKLRDHSVTLRKsRra----eRTKKIVEQTIDVKCHRLALGRRNYIYLA 126 
P21691         82 FFLLEDGRIILKRiRs------KLRYKVVKKLTCKCCRLYLPKWGTVYIH 125  Saccharomyces cerevisiae S288C
XP_003672439   78 FVELLDGRIVPKStQ-------IPTTEVLDEFSRKCHKLTLSNKISKYLF 120 
XP_003678548   80 FVKTVDGELKLKNsV-------IANQSIVNEFTKKCHKITLENGKEVYLF 122 
XP_003670063   77 FLRMKDHTITREKeSiwnrnrnRNRNRIVDIIEVQAHKISISNHKVVYLH 126  Naumovozyma dairenensis CBS 421
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