6P7J


Conserved Protein Domain Family
TGFb_propeptide

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pfam00688: TGFb_propeptide 
TGF-beta propeptide
This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.
Statistics
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PSSM-Id: 459906
Aligned: 61 rows
Threshold Bit Score: 145.928
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6P7J_A         1 LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQg--eVPP---GPLP-EAVLALYNSTR--DRvagesaepepePE- 71 
XP_020845611  43 EGCPVCVWRQHSKELRLESIKSQILSKLRLKEAPNIsrevVKQllpKAPPlQEILDLHDFQG--DAl---------qPEd 111
EDO39129      22 ESSSQRAKHEVRNSADFQMMEQRFLDTMGMRSRPRPkr-------gTRIP-QYMLDLYNSHkahpdwistq--------- 84 
NP_571417     37 ALHLAQ-SHE-----LLRDFEATLLHMFGLQRRPRPsh-------sAVVP-QYLLDLYRLQs--Geleeagaqhvs---- 96 
XP_006097026  43 GGRRSGQSHE-----LLRDFEATLLQMFGLRRRPQPsk-------sAVIP-EYMRDLYRLQs--GEeeeeeqihsia--- 104
XP_005986540  43 GGRRSGQSHE-----LLREFEASLLQMFGLQRRPQPsk-------sVVVP-RYMLDLYRFQs--GDenvkdinfk----- 102
Q804S2        37 GKQSPQQSEG-----FLNEFELRLLNMFGLKRRPTPsk-------qAVVP-QYMVDLYRMHSanGDhsakrpksmg---- 99  spotted green p...
XP_007670287  37 GRSTPQRSED-----ILSEFELRLLNMFGLKRRPNPsk-------gAVIP-PYMLDLYRLHs--GQleepamdy------ 95 
Q90YD7        37 GRSSPQHSQS-----VLNQFELRLLNMFGLKRRPTPgk-------nIVIP-PYMLDLYHLHs--GQlaadqdsspm---- 97  tropical clawed...
XP_005991150  37 GRSSPQQSEE-----ILNEFELRLLNMFGLKRRPNPgk-------sAVIP-QYMRDLYRLYSrsGEdsldqhgssl---- 99  coelacanth
6P7J_A        72 ----------ADYYAKEVTRVLMveTHNEiydkfkqsTHS---------------IYMFFNTSElreaVPEPVLLSR--- 123
XP_020845611 112 fleedeyhatTETVISMAQETDPavQTDGs-------PHC---------------CHFHFSPKV----M--FTKVLKaql 163
EDO39129      85 -frfgdkwigANTIRAF--------------------HHTdndgida--sensnlTRIIFDLST----LPMYETVTSael 137
NP_571417     97 fdyperstsrANTVRGF--------------------HHEehleelqsdgsqetpLRFVFNLSS----IPEDELISTael 152
XP_006097026 105 leyperpasrANTVRSF--------------------HHEehlenip-gtsensaFRFLFNLSS----IPENEVISSael 159
XP_005986540 103 --yperstsrANTVRSF--------------------HHEerlekds-ansddslSHFIFNISS----LPENEVFSSael 155
Q804S2       100 -rhaeraaskANTIRSF--------------------HHEesmeala-rlkgkttQQFYFNLTS----IPKEELITSael 153 spotted green p...
XP_007670287  96 --rleraasrANTVRSF--------------------HHEesleelp-easgttaRRFFFNLTS----VPNEEFITSael 148
Q90YD7        98 dyqieraasrANTVRSF--------------------HHEesmeeip-esgektiQRFFFNLSS----VPNEELVTSael 152 tropical clawed...
XP_005991150 100 npqlersasrANTIRSF--------------------HHEesleelp-etgtktaRHFFFNLSS----IPGEEMPASael 154 coelacanth
6P7J_A       124 --A---------------ELRLLRLKLK-VEQHVELYQKy--------SNNSWRYLSNRLLaP-SDSPEWLSFDVTGVVR 176
XP_020845611 164 wvYl-------------rPVPRPATVYL-QILRLKPLVGkelqevgvgGRRHIRIRSLKIE-LhSRSGHWQSIDFKQVLH 228
EDO39129     138 rlStrsgdl--------------kqpsnsTQLWIRVYQVllpg--mgdTPALRRLLDSREV-D-ARVAGWESFNVELAIQ 199
NP_571417    153 rvYrqqiddafsdpdqtgDH---------GLHRINIYEVlka---preGQLITQLLDTRLV-R-HNTSKWESFDVSPAVL 218
XP_006097026 160 rlFreqvdq--------------gpdweqGFHRINIYEVmkppaelvsGHLITRLLDTRLV-H-HNVTRWETFDVSPAVL 223
XP_005986540 156 rlYreqieq--------------gpsweeHFHRINIYEVmrpp--srnGQLITRLLDTRLV-H-QNATQWESFDVSPAVV 217
Q804S2       154 riYrdqvmgaastnnsstNSSTSDKAHAgGFHRINIYEIfgv---pqgREPLARLLDTRLV-Q-DSLTRWESFDVSSAVF 228 spotted green p...
XP_007670287 149 qvFreqvrea-------------ldnnsgYHHRINIYEIikpa-taisKDPVTRLLDTRLV-N-HNASKWESFDVTPAVT 212
Q90YD7       153 riFregvqep-------------fegdssKLHRINIYDIvkpa-aaasRGPVVRLLDTRLI-H-HNESKWESFDVTPAIT 216 tropical clawed...
XP_005991150 155 riFreevqpt-------------lannssGHHRINIYEIimpa-sstlRDPITRLLDTRLV-H-QSQSKWESFDVTSAVM 218 coelacanth
6P7J_A       177 QWLSRgGEIEGFRLSAHCSc----dSrDNT-LQVDING-----FtTGRRG--DLATihgmnRPFLLLM 232
XP_020845611 229 SWFRQpQSNWGIEINAFDP------S-GTD-LAVTSLG-----P--GAEG-----L-----HPFM-EL 270
EDO39129     200 HWVKNpEQNYGLDIQVTT-------------KEGHSIKdavrtR-EHHAEedWHEE-----RPLIVTY 248
NP_571417    219 RWTQEkRSNHGLAVEVVQm-----kR-NPV-QKGRHVRvs-rsV-HPLPDeeWDQL-----RPLLVTF 272
XP_006097026 224 RWTQEkQPNYGLAIEVTHl-----hQ-TRT-HQGQHVRis-rsL--PQGSgdWAQL-----RPLLVTF 276
XP_005986540 218 RWIRDkQPYRGFAVEVIHl-----nQ-TKT-HQGKHVRis-rsL--PQGDtdWSQL-----RPLLVTF 270
Q804S2       229 QWTSGkGHNHGFMIEVLHPeegeveQ-ERAdKHSRHVRvs-rsL--HQDRdsWPQA-----RPLLVTY 287 spotted green pufferfish
XP_007670287 213 RWIAQgQPNHGFVVEVVHl-----eD-ERG-VSERHVRis-rsL--HQDEqsWPQI-----RPLLVTF 265
Q90YD7       217 RWIAHkQPNHGFVVEVTHl-----dN-DKN-VPKKHVRis-rsL--VPDKdsWPRI-----RPLLVTF 269 tropical clawed frog
XP_005991150 219 RWLMYqEPNHGFVVEVVHv-----dK-EES-ASKRHVRis-rsL--HEDEesWPQM-----RPLLVTF 271 coelacanth
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