1JS6,1XEY,2JIS,2QMA


Conserved Protein Domain Family
DOPA_deC_like
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cd06450: DOPA_deC_like 
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DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Links
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Statistics
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PSSM-Id: 99743
Aligned: 40 rows
Threshold Bit Score: 312.6
Created: 30-Jun-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1JS6_A; catalytic residue (lys) and cofactor (PLP)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1JS6_A     76 FFAYfpta--ssypAMLADMLcgaigcigfs--waaspacteLETVMMDWLGKMlqlpeaflageagegGGVIQGsASEA 151 pig
CAA09590  144 RASGtvys--geekLTELLVKaygdfawsnplhpdifpglrkIEAEIVRIACSLfngg--------pdsCGCVTSgGTES 213 human
NP_616872  67 NLASfvntw-mepeADKLVMEniskniidi---feypqtsrvIHHNMVNMLGRLfngh-------htdfVGTSTAgSSEA 135 Methanosarcina ace...
NP_652032 132 RVSGavyg--ykpdLVELVTEvygkasytnplhadlfpgvckMEAEVVRMACNLfhgn--------sasCGTMTTgGTES 201 fruit fly
NP_499913 138 RVSGavytd-rhaeHINLLGKiyekyafsnplhpdvfpgarkMEAELIRMVLNLyngp--------edsSGSVTSgGTES 208 Caenorhabditis ele...
CAB91763  146 YVSGavys--gedeLLKLQTEaygkftvanpihpdvfpgvrkMEAEVVAMVLSLfnap--------pgaAGVSTSgGTES 215 Neurospora crassa
NP_010580 168 KVSGavyh--ggddLIHLQTIayekycvanqlhpdvfpavrkMESEVVSMVLRMfnap-------sdtgCGTTTSgGTES 238 baker's yeast
AAP37027  116 KVSGcvyl--gekeHTKLLNEayslfslsnplhpsvfpsirkFETESISMVSNMlnah--------skvVGSLTSgGTES 185 Dictyostelium disc...
NP_188403  58 NLASfvttw-mepeCDKLIMDsvnknyvdm----deypvtteLQNRCVNMIANLfhapvg----edeaaIGCGTVgSSEA 128 thale cress
NP_505372 130 RVSGavfnreddkdEREMYEEvfgkfawtnplwpklfpgvriMEAEVVRMCCNMmngd--------setCGTMSTgGSIS 201 Caenorhabditis ele...

Feature 1                                                                                     
1JS6_A    152 TLVALLAArtkvvrrlqaaspgltqgavleklVAYASdqAHSSVERAGLiggvKLKAIpsdgkf-amrasALQEALerdk 230 pig
CAA09590  214 ILMACKAYrdlafe------------kgiktpEIVAPqsAHAAFNKAASyfgmKIVRVpltkmm-evdvrAMRRAIsr-- 278 human
NP_616872 136 IMLGLLAHkwswkks----------grgtdkpNIIFGndAHVCWDKFARyfdvDTRKVpidkdrrtitaeAVAERIde-- 203 Methanosarcina ace...
NP_652032 202 IVMAMKAYrdfarey-----------kgitrpNIVVPktVHAAFDKGGQyfniHVRSVdvdpetyevdikKFKRAInr-- 268 fruit fly
NP_499913 209 IIMACFSYrnrahs------------lgiehpVILACktAHAAFDKAAHlcgmRLRHVpvdsdn-rvdlkEMERLIds-- 273 Caenorhabditis ele...
CAB91763  216 ILMAILSArqkayhe-----------rgvtepEMIIPetAHTAFRKAAEyfniKLHLVacpaptyqvdtkRVARLInr-- 282 Neurospora crassa
NP_010580 239 LLLACLSAkmyalhh-----------rgitepEIIAPvtAHAGFDKAAYyfgmKLRHVeldpttyqvdlgKVKKFInk-- 305 baker's yeast
AAP37027  186 IFMAVKAYrdfykd-------------rtdrpEIVVPvtIHAAFDKACEylkiRIVHIdvgpvsykvdmaAMKKAInk-- 250 Dictyostelium disc...
NP_188403 129 IMLAGLAFkrkwqhrrk------aqglpidkpNIVTGanVQVCWEKFARyfevELKEVklsedyyvmdpaKAVEMVde-- 200 thale cress
NP_505372 202 ILLACLAHrnrllkr-----------gekyteMIVPSsvHAAFFKAAECfr-iKVRKIpvdpvtfkvdlvKMKAAInk-- 267 Caenorhabditis ele...

Feature 1                                                                                     
1JS6_A    231 aagliPFFVVATLGTTsccsfdnLLEVGPICHee------dIWLHVDAAYAGSAFicpefrhl------lngvefaDSFN 298 pig
CAA09590  279 ----nTAMLVCSTPQFphgvidpVPEVAKLAVky------kIPLHVDACLGGFLIvfmekagyplehpfdfrvkgvTSIS 348 human
NP_616872 204 ----nTICVGCVLGTTftgeidpVKDINDLLLeykeekgwdIPIHIDAASGGFILpftepdfe-----wdfrlervKSIN 274 Methanosarcina ace...
NP_652032 269 ----nTILLVGSAPNFpygtiddIEAIAALGVky------dIPVHVDACLGSFVValvrnagykl-rpfdfevkgvTSIS 337 fruit fly
NP_499913 274 ----nVCMLVGSAPNFpsgtidpIPEIAKLGKky------gIPVHVDACLGGFMIpfmndagyli-pvfdfrnpgvTSIS 342 Caenorhabditis ele...
CAB91763  283 ----nTIMLVGSAPNFphgiiddISALSKLALrk------kIPLHVDCCLGSFLVpfldkagfds-qpfdfrlkgvTSIS 351 Neurospora crassa
NP_010580 306 ----nTILLVGSAPNFphgiaddIEGLGKIAQky------kLPLHVDSCLGSFIVsfmekagyknlplldfrvpgvTSIS 375 baker's yeast
AAP37027  251 ----dTILVAGSAVNFphgiidpIDEIAKLAQqy------dIGCHVDACLGGFILpfaekldydi-pvfdfripgvTSMS 319 Dictyostelium disc...
NP_188403 201 ----nTICVAAILGSTltgefedVKQLNDLLAeknaetgweTPIHVDAASGGFIApflypdle-----wdfrlpwvKSIN 271 thale cress
NP_505372 268 ----rTCMLVGSAPNFpfgtvddIEAIGQLGLey------dIPVHVDACLGGFLLpfleedeir----ydfrvpgvSSIS 333 Caenorhabditis ele...

Feature 1         #                                                                           
1JS6_A    299 FNPHKWLLVnfDCSAMWVKrrtdltgafkldpvylkhshqgsglitdyrhwqlplgrrfrSLKMWFVFRmygvkglQAYI 378 pig
CAA09590  349 ADTHKYGYApkGSSLVLYSdkkyrnyqffvdtdwqg--------giyasptiagsrpggiSAAAWAALMhfgengyVEAT 420 human
NP_616872 275 VSGHKYGLTypGLGWLIFRnknalpedlifhvnylg--------emedsytlnfsggsamVAAQYYNFLrfgragyTGIM 346 Methanosarcina ace...
NP_652032 338 ADTHKYGFApkGSSVILYSdkkykdhqftvttdwpg--------gvygsptvngsraggiIAACWATMMsfgydgyLEAT 409 fruit fly
NP_499913 343 CDTHKYGCTpkGSSIVMYRskelhhfqyfsvadwcg--------giyatptiagsraganTAVAWATLLsfgrdeyVRRC 414 Caenorhabditis ele...
CAB91763  352 CDTHKYGFApkGNSTVLYRtaelrsyqyfvdpswsg--------gvyaspgiagsrpgalIAACWASLMsvgeegyLKSC 423 Neurospora crassa
NP_010580 376 CDTHKYGFApkGSSVIMYRnsdlrmhqyyvnpawtg--------glygsptlagsrpgaiVVGCWATMVnmgengyIESC 447 baker's yeast
AAP37027  320 VDTHKFGYAakGTSVVLFGnkklrramyfvapnwpg--------giyasptlpgsrpgglVAACWASLVsmgndgfLEKA 391 Dictyostelium disc...
NP_188403 272 VSGHKYGLVyaGVGWVVWRtkddlpeelvfhinylg--------adqptftlnfskgssqIIAQYYQFIrlgfegyKNIM 343 thale cress
NP_505372 334 ADSHKYGLApkGSSVVLYRnkellhnqyfcdadwqg--------giyasatmegsraghnIALCWAAMLyhaqegyKANA 405 Caenorhabditis ele...

Feature 1                                                                                     
1JS6_A    379 RKHVQLSHEFEAfvlqdprf-evcaevtlGLVCFRlkgs--dglNEALLERINsarkIHLVPCrlr----gqfVLRFAIC 451 pig
CAA09590  421 KQIIKTARFLKSelenikgi-fvfgnpqlSVIALGsrd----fdIYRLSNLMTak-gWNLNQLqf------ppSIHFCIT 488 human
NP_616872 347 KKILAVSQDLAEkvdrlgrfemlnkgerlPIIAFRqkek-tgysLLQLSHKLRek-gWIVPAYclpenaadieIMRIVVR 424 Methanosarcina ace...
NP_652032 410 KRIVDTARYIERgvrdidgi-fifgkpatSVIALGsnv----fdIFRLSDSLCkl-gWNLNALqf------psGIHLCVT 477 fruit fly
NP_499913 415 AQIVKHTRMLAEkiekikwi-kpygksdvSLVAFSgng----vnIYEVSDKMMkl-gWNLNTLqn------paAIHICLT 482 Caenorhabditis ele...
CAB91763  424 TQIVGATKKLAEhirshptlqqeleilgnPLVSVLafqargdlnIYDIADGMSsr-gWHLNALqn------ppAIHVAVT 496 Neurospora crassa
NP_010580 448 QEIVGAAMKFKKyiqenipdlnimgnprySVISFSskt----lnIHELSDRLSkk-gWHFNALqk------pvALHMAFT 516 baker's yeast
AAP37027  392 KGVMETTKKIIKglqsingv-kiigdpkaMVVAFTcd------nIFYVNDYMSkk-gWHLNALqr------pnSLHVCVT 457 Dictyostelium disc...
NP_188403 344 ENCMDNARRLREgiemtgkfnivskdigvPLVAFSlkds-skhtVFEIAESLRkf-gWIIPAYtmpadaqhiaVLRVVIR 421 thale cress
NP_505372 406 RKIVDTTRKIRNglsnikgi-klqgpsdvCIVSWTtnd---gveLYRFHNFMKek-hWQLNGLqf------paGVHIMVT 474 Caenorhabditis ele...

Feature 1                        
1JS6_A    452 srkvesGHVRLAWEHIRGL 470 pig
CAA09590  489 llharkRVAIQFLKDIRES 507 human
NP_616872 425 enl-tpDMASIIVEDLEKA 442 Methanosarcina acetivorans C2A
NP_652032 478 dmhtqpGVADKFIADVRSC 496 fruit fly
NP_499913 483 inqaneEVVNAFAVDLEKI 501 Caenorhabditis elegans
CAB91763  497 ap--vaKNWERLAQDLEGV 513 Neurospora crassa
NP_010580 517 rl--saHVVDEICDILRTT 533 baker's yeast
AAP37027  458 ak--miGMESLFIEDLKDS 474 Dictyostelium discoideum
NP_188403 422 edf-srGLADRLITHIIQV 439 thale cress
NP_505372 475 mnhthpGLAEAFVADCRAA 493 Caenorhabditis elegans

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