6Y79


Conserved Protein Domain Family
NDUF_B7

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pfam05676: NDUF_B7 
NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
This family consists of several NADH-ubiquinone oxidoreductase B18 subunit proteins from different eukaryotic organizms. Oxidative phosphorylation is the well-characterized process in which ATP, the principal carrier of chemical energy of individual cells, is produced due to a mitochondrial proton gradient formed by the transfer of electrons from NADH and FADH2 to molecular oxygen. The oxidative phosphorylation (OXPHOS) system is located in the mitochondrial inner membrane and consists of five multi-subunit enzyme complexes and two small electron carriers: coenzyme Q10 and cytochrome C. At least 70 structural proteins involved in the formation of the whole OXPHOS system are encoded by nuclear genes, whereas 13 structural proteins are encoded by the mitochondrial genome. Deficiency of NADH ubiquinone oxidoreductase, the first enzyme complex of the mitochondrial respiratory chain, is one of the most frequent causes of human mitochondrial encephalomyopathies.
Statistics
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PSSM-Id: 461710
Aligned: 70 rows
Threshold Bit Score: 64.1283
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6Y79_8         8 LSQEDMKKHKILLAYRDRCAALLVPLNECRKKNYY-MPWACGHERHEYEMCEVADFQRRVKAM 69  Yarrowia lipolytica
XP_008187501  40 ASLAEMESAKVPLDARDFCAHMLLNLRGCIRDNFP-FNHHCHHEREEYYECQYHDYLDRMKDY 101
XP_025018631  46 ATEAEMESAGLPDEKRDYCAHWVIKYDACVRDNLP-FLRTCSYYKEGWRDCQYNDMVLRMKEY 107
XP_002405984  48 ATEAELESARIPPKSRNYCAHKLIEFKACRKDHFP-LVYRCQHEKHEYDDCLYQDYLIRYKEY 109
OWR47599      40 AKEEDLISARIPPKYRDYCAHHLLEYQVCRYKNVP-LMYKCAHEKHAYLNCEHQDYVMRMKEF 101
XP_002123568  37 ATSEEMDKAALRREERDYCAHMFMDIMKCRREWFP-ELYNCRPLIEKYQHCTVNDIKHRMLEY 98 
XP_018645208  40 LTEEEMIAAGLKPYERDYCAHLLLAFRKCGDEHVI-PALYCSDLKHKYRHCKESDLLHRMKEY 101
CCE40758      14 PSQQELDDHNVPFYYRDKCASNLIEYYKCLDKGTS----FCNKTKDEFYKCQYYLLKGRLDSy 72 
CAR65779      10 LSEEDLQKYKVPLRWRDRCAANFALYHICLKRQSAnSSVDCKHDKHVWEECENLDFIRRQKEL 72 
EGV60372      10 lSDDDLQKYKVPLKWRDRCAFYFALYQTCLIRQSAnGSVDCGHDKHAWEECENLDLIRRKQEl 72 
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