Conserved Protein Domain Family
Lebercilin
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pfam15619: Lebercilin 
Ciliary protein causing Leber congenital amaurosis disease
Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.
Links
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Statistics
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PSSM-Id: 464776
Aligned: 35 rows
Threshold Bit Score: 128.482
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EGD73137      63 QSAGTRQYtAELEDKLHNKDMQLQELKKEMKVLQDIQRRQEKALDKLEGNDSELPQRLRQRDEEIRSLREQLRKAKDTVH 142
4_pfamImport   1 MSAKLLRV-KQLQNQLAESQSVVNELLTENKLLKTLQRRQDNALKKYEGSQEQLPQLIKSHNEEIRIINTRFKQLKLNYK 79 
OWR48087      57 LSAKTHRV-KQLQNQLADAHYHLQELSNENKVLRALQKKQEIALQRYENSNAELPQVLSSHSEEMRIQQCKYKQLKTQYK 135
XP_008212504 115 CSAKMIRI-KQLQNQLADAHFHLNELSNENKLLKAIQKRQDAALKRYEGTNAELPRIINTHHEDLRVLQTKHKKLRSQYK 193
XP_002068418  78 MSARNLRM-KTFQNQLADAQAEIANLAHENRMLRTLHKRQSSALNKYESTNAELPQLLHSHSEELRVWQTKHRNLQAINK 156
XP_969980     59 LSAKLLKL-KSVQNQLNDANYHLAEVIRENQALKTLQKRQDRALSKYEGANAELPRLIQSHEEEIRFLTEKNKQLRRNVK 137
EEB20088      34 MSAKLLKV-KQVQNQLNETQIQLNELINENKVLRNMQKRQEGALKRYEGNYAELPQLIRSHNEEIRTLKASNKQIKAQLR 112
CDS43312     104 WQASQNLI-GSLRSENHLLQSQLKECRIELRTVQRQCKVQSARLSKVVGREAEMPAVIDRLNAEVRAMQIRLRRKQEAVD 182
CUT98867      66 LMAKQEVL-NDQQCQLDFLKSKVCALKEDNRMLKAQGHVQAAIIEKLDGKNAKLPMLVNSQMEEIRVYREQLKRLKDIFV 144
XP_001742937  66 VSSAEREYqNGLQSRLQAAEKENQELRRELKLLEKIQRRQTKAIDQYEGSNSELPSQLRQREEELRALREQMRNLKARNT 145

EGD73137     143 TMKENQRKKDKHLQSIRDKTRQLDQ-LVQDKGLRERAELESE---LAAMKQRVQEQEEEMGRLRRKAELEEKARVRMEQQ 218
4_pfamImport  80 VLESKLKDRDSELSNLKEQHKHLLK-LSRDKQLYDREKLTKK---LEELEKHVQSQQEKIQILTRKLELEGKSYRHKLNI 155
OWR48087     136 DITQKLKEREMQLQQLRDEHLHLVE-LSKDRNLLEREKLQSQ---VTELNAKVQQQTETINMLQRRIALEAKNFKHQLQN 211
XP_008212504 194 EKCEQLKEKENELHSLQTQNKKLLQ-LSKDRHLGEREKLQTQ---VFDLSHRISQQDETIQTLKRKLALETKYLKHQLHA 269
XP_002068418 157 DLEMKLKQKEALILSLSDQNKHYSQ-LNKDKNLDERQKLQEK---LRSLEQRLQDKDNDMKLMARKVQLETKNFRQQLLN 232
XP_969980    138 ELNEQLKYKNDELQSLQEQLKHYEK-LDKDKHLLEREKLIEE---LEDVKKKLAKADSEIVVLNRKLTLESKTSKQRLNM 213
EEB20088     113 ESNTKLKERENELESLRDSYTKLKK-LSMEKNLLEREKLQKK---VEDLQDVIKEQEEKIQVLSRKILLESKNYRHQLNV 188
CDS43312     183 LAERRALEAEARLLPLLEKRDHKSAtVPSAASANEHEEIKKRtqaIDTLQTTLEEERRKFRDLQRKMELMERNHRTEQAA 262
CUT98867     145 RTNKAMQESESARYRAEEELQHLRD-LAFEQNLPEREELVSA---LQQLREEYESIERDKVALEKYVHNLEKNQRCERTR 220
XP_001742937 146 ELEASHQKKDKHMQQVRDKARRLES-LVKDKDLLEAATATER---VHQLEQELQTKNEAVSKLQHHCDLLQKQLARAEAS 221

EGD73137     219 EVKMKAAHKAKVTALQQQVEDLEAAVAEKDRQL 251
4_pfamImport 156 EICKHKETQAELREARKTIDNLKSSIEGKQKYV 188
OWR48087     212 EMNKHKDTRHDLDLAISNADKLSTIIEMKEKML 244
XP_008212504 270 ELVKHKETQKTLQDTQEKLKKFEQLNKQREKQY 302
XP_002068418 233 EQKKGKEVMLKLEKARLELSGYRKLEEYTLGVN 265
XP_969980    214 EMVKHKQCQKELAQALTEIAKLTKLIEIKEKPS 246
EEB20088     189 EILKHKETQKDLNSALTVINKLESQLFSKDTKS 221
CDS43312     263 ANEQIRKMRKFVSDLQAQLNIVNRSLQEKTK-L 294
CUT98867     221 LLRQQRDLQAKCATLASTVRGLQTDLQEKQRML 253
XP_001742937 222 QGKQVSQVKGEVSHLERRIEELEDKLAARDRQL 254
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