4P0T


Conserved Protein Domain Family
CENP-M
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pfam11111: CENP-M 
Centromere protein M (CENP-M)
The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival.
Links
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Statistics
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PSSM-Id: 463224
Aligned: 14 rows
Threshold Bit Score: 248.386
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4P0T_A         6 MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKE--DCASELKVHLAKSLPLPSSVN--RPRIDLIVFVVNLHSKY 81 
AAI35575       1 MATLRPFDKMPMLNAAALLLVGTEESHREQLASAMLKE--PKTFEVKIHMAQSLPLPYEREhlRPRFDMVVFLINLHSQF 78 
Q1T7B9         1 MAVLRPFDKLPELNSATILLVGAEGGPQQQLAEAMLRE--KKDFNINIHLASSLPLPSERDhlRPRIDLIAFVIDIKSKY 78  chicken
XP_005039726   1 MAVLRPFDKLPMLNSCVILLVGSDEAIQQKLAEAMLQE--KRNFNVSIHLATSLPLPSERDhlRPRIDMVVFMIDIKSKY 78 
Q9CQA0         1 MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKD--DCASELRVHLANSLPLPSNVN--RPRIDLIVFVINLHSKY 76  house mouse
XP_006011016   1 MSVLKPFDKLPELNTATVLLVGAEEHYLEKLAEIIAKE--TQPFKINVRTAKRLPLPTENDyiRPRIDLIVFIINLHNKQ 78 
XP_003447922   1 MSLLKPFSKLPGLNTANILLVESEEQFQQSLADALVE---ETSVTVNVRLAKSLPLPMENDesRPRIDLVVFIINLTSEL 77 
Q7ZZC6         1 MALLSPYSKVPELNTATVLLVENEEELQNKLANAIVQH--EKDFNVNVRLAKKLPLPVENKeaRPRIDLIVFIVSLLSER 78  zebrafish
XP_030840712   9 QPVLHPFNKLPELNSAVVLLIGFQSIKKKELAEAMVAL--NTEFCLQVRTATQLPLPSINDeqRPKIDLIVFILDVNVNM 86 
EEN51762      15 REILKPFNKMPVRNAATVLLVGSYGTGKKQLAKSMVDVctDTGLKLQVRTTTSLPLPEENTdtRPRIDYIAFIIDLTNRL 94 

4P0T_A        82 SLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKLAHTYQSPLLYCDLEV--EGFRATMAQRLVRVLQICA 159
AAI35575      79 SLSTVLASLTHLDVNFFLGKVCFVAIGGGQVKHCMVDIATVKKLADTHLSTLLFSEFDS--EDDVTCTARRLLQMVQICA 156
Q1T7B9        79 SLKNVQASLAYVDVRFFLGKVCFLVTGVGRANNCSVEMNAIWKLGEDYCSPVIFCELEL--EGIRVATAQRLLRMLQICA 156 chicken
XP_005039726  79 SLKNVETSLAHVDASFFLGKVCFLVTGVGRVNACSIETNAVCKLAEAYCSPVLFCELEL--EGVRAATAQRLLRMLQICA 156
Q9CQA0        77 SLQKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQV--ESFRAAMARRLVRILQICA 154 house mouse
XP_006011016  79 SLSVVESALAFVDVKFFLGKVCFLATGVGMVKYCSVEAYSVRKLAESCCCPVIYTELES--RKERESTAQRLVRMLKISA 156
XP_003447922  78 SFQSAEASLKYLDPGYFLGKVCFMVTNARNASSPAERLDAVRKLASSLHCPLLFAEDQT--PDGVASATERLLTILKVAA 155
Q7ZZC6        79 SLQSAESSLSHLHSDCFLGKVCFLVTDARCGSHTQERLVSVRKLAASHHCPVICAEHRT--ADGVSAAALRLLNILQVSA 156 zebrafish
XP_030840712  87 SLKTVADSLPHLDPTYFLGRVCFLALNAPSEKTQCADLGDILALCDAYDSPLICGDLET--QEQRESLARRLVEMTEIAA 164
EEN51762      95 SFSTVQSAVQCVDVEYFLGRACFVVTNVKGTSDHCVEMEEVSRLADMYNTMYICGGIKEgdPDERTTLANRLLQLVEVSA 174

4P0T_A       160 GHVP-GVSALNLLSLLRS 176
AAI35575     157 GLVP-GISALYLGSFMNS 173
Q1T7B9       157 GRVP-GVSALYFSLLMRN 173 chicken
XP_005039726 157 GHIP-GVSALSLVSLMRN 173
Q9CQA0       155 GHVP-GVSALNLMSLLRS 171 house mouse
XP_006011016 157 GFVP-GVSALFFSSLLKT 173
XP_003447922 156 GLVP-IATALYVSNLTRC 172
Q7ZZC6       157 GMTPmSTTALYLSTLTRC 174 zebrafish
XP_030840712 165 GFKN-GISPLLIQSTRRS 181
EEN51762     175 GRKN--VSPLLVDLTCRQ 190
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