1A0A


Conserved Protein Domain Family
bHLH_ScPHO4_like
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cd11392: bHLH_ScPHO4_like 
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basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system positive regulatory protein PHO4 and similar proteins
PHO4 is a transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions in Saccharomyces cerevisiae. The PHO4 protein has four functional domains with the bHLH domain at its carboxyl-terminal region. It regulates transcription by binding to promoter of the genes as a homodimer.
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Statistics
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PSSM-Id: 381398
Aligned: 11 rows
Threshold Bit Score: 70.1723
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:1AOA; Saccharomyces cerevisiae bHLH domain of PHO4 binds DNA, contacts at 4.0A
  • Citation:PMID 9303313
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ######  ## ##                                                             ##   
1A0A_A         1 MKRESHKHAEQARRNRLAVALHELASLIPAEwkqqn----------------------------------vsaapSKATT 46  baker's yeast
P20824       645 SKRTSHKIAEQGRRNRINSALQEIATLLPKApakeggdgdgdghsssgggggsggadredkrekdkdkagggipnSKAST 724 Neurospora cras...
POE77608     565 SKRTSHKVAEQGRRNRINEALKEMQSLLPKAvvlkkeqsgsdaspdaeqr-------adedskdtkedaaaksnsSKAAT 637 Quercus suber
OGE55817     300 QKRTYHRLAERNRRDKFNAAIKEMEALIPAEfvdernkalglaltais-----------nssstkkkekapsaeqTKADV 368 Penicillium sp....
CEO60357     505 SEHDALEVSKEGPRKRINAALKDIESLIPSDfvrprmvkdnaisdv--------------kpenntekepivrarSKATI 570 Penicillium bra...
KFA51440     176 LQRGTHNAAERNRRDRLTFAIERLAKLLEQEccpsgddsaasqqa-----------------saastsklmrkscSKAAV 238 Stachybotrys ch...
XP_009157581  46 SKQRAHMIDERNRRNRLSRAIQTLQGLMPQMdavgk----------------------------------qkkgpCKAIT 91  Exophiala derma...
KFY02612      95 SKRVAHSAAERGRRERLKKALQKLAELMIADrdedlggalsse--------------------ffeagalaaqtgNKAAI 154 Pseudogymnoascu...
POR31058      33 IKRHQRKVSEKARRDHLKKALARLGQLMMTPccegymgaidvagr-----------------spdagpsaasfvgSKTDV 95  Elaphocordyceps...
KOS44032      51 TRRRQHADAQKCQRDRMKAALGQIERIMRMGgtgnk-----------------------------------emsgTKAEL 95  Penicillium nor...
P07270       250 DKRESHKHAEQARRNRLAVALHELASLIPAEwkqqn----------------------------------vsaapSKATT 295 Saccharomyces c...

Feature 1                         
1A0A_A        47 VEAACRYIRHLQQNGST 63  baker's yeast
P20824       725 VEMAIEYIKQLQKEVAD 741 Neurospora crassa OR74A
POE77608     638 VESANEYIRRLQREHGE 654 Quercus suber
OGE55817     369 MEIAADYIKMLRATLDE 385 Penicillium sp. JCN-2016
CEO60357     571 VEMTVDYIKEMQQNLKG 587 Penicillium brasilianum
KFA51440     239 VESAIKYITDFHDRLDQ 255 Stachybotrys chartarum IBT 40293
XP_009157581  92 VERAIDYIIALQREVER 108 Exophiala dermatitidis NIH/UT8656
KFY02612     155 VEMAVEYISSQRKTVVE 171 Pseudogymnoascus pannorum VKM F-3557
POR31058      96 VEFAIQYISCFQRYLLD 112 Elaphocordyceps paradoxa
KOS44032      96 LETAVDYIQHLQKQVEE 112 Penicillium nordicum
P07270       296 VEAACRYIRHLQQNVST 312 Saccharomyces cerevisiae S288C

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