Conserved Protein Domain Family
Adaptin_binding

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pfam10199: Adaptin_binding 
Alpha and gamma adaptin binding protein p34
p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane.
Statistics
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PSSM-Id: 462994
Aligned: 27 rows
Threshold Bit Score: 48.6566
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS69940 277 DKDGIE--RIREALMNHMWNGLirkdqtaslsnrnasletgpalfassdahpsfsdsavgrfkgdeedtdpaeaiqdsae 354
EAY10941 135 EEQQPAgtRIMESLELVDWPIK---------------------------------------------------------- 156
A0C1I4   172 ETLGFP--RIIEIMECNTWTYMrpk------------------------------------------------------- 194 Paramecium tetraurelia
Q22XW2   202 ETDGIA--RIIDILESNVWTDSemfkvekkqnleqqhtklnihiptyeknkdirekyek--------------------- 258 Tetrahymena thermop...
EDL43988 275 EQEDDE--RLVEALHCHMWKGLqikrdhliiqhrgdfpmg---------------------------------------- 312
A5DMM1   176 DKLGID--RLVELFDTHDWSDIetse------------------------------------------------------ 199 Meyerozyma guillier...
EDK46214 218 EKQGKE--RVREVMESHDWPNIdpasfpnvqds----------------------------------------------- 248
Q6FWX8   184 ECKGMA--RLKEIIDTHPWTDCk--------------------------------------------------------- 204 [Candida] glabrata ...
Q6BHQ2   183 DKIGQD--RLLEIIETHEWSQMdlkq------------------------------------------------------ 206 Debaryomyces hansenii
ABN65850 144 EKIGTD--RLVELIETHEWTHMdl-------------------------------------------------------- 165
KIS69940 355 salepsslrhhlatigdsfsdntgfpmldsnahadasdldeqlaklflsandgaraadlAQLEAFLESQDPSWPASTPPP 434
EAY10941 157 -----------------------------------------------------------MSAGKPRMEQRIEQMVALLKS 177
A0C1I4   195 --------------------------------------------------------sqeKKENTGKTKVSEKQTQGLDQL 218 Paramecium tetraurelia
Q22XW2   259 ----------------------ygnnnddeeeeeinlekqnnilkvnkneeiekqelkdKKQEVKEVNSNQEQKQQMEID 316 Tetrahymena thermop...
EDL43988 313 ------------------------------------------eafkgdeaarkgektpqKDEASPNGEKTPQKDEAAPNG 350
A5DMM1   200 --------------------------------------------------------ddgFAARKRKMAESMCQRLLDDDE 223 Meyerozyma guillier...
EDK46214 249 ------------------------------------------------kmkeernrakiKALEDPLVKKQPQQEDLRVEE 280
Q6FWX8   205 ----------------------------------------------------------vVLKNKESTSDKVNKP------ 220 [Candida] glabrata ...
Q6BHQ2   207 -------------------------------------------------------grdqDAYDETKRNKMSDMTKGLLDG 231 Debaryomyces hansenii
ABN65850     --------------------------------------------------------------------------------    
KIS69940 435 KSaadpesadarfdddfddflpfqsalsdatqstsqnasadvddlptmddisqmqnhlfgglaaARIEanppgaatrsns 514
EAY10941 178 ND--------------------------------------------------------------PECE------------ 183
A0C1I4   219 E---------------------------------------------------------------FEDD------------ 223 Paramecium tetraurelia
Q22XW2   317 NKkqeeqqlskeneqlnnndtnkninsnqipeqkednktkeqeenkskdsknkqnkqnikydndDDEEiqen-------- 388 Tetrahymena thermop...
EDL43988 351 ENppqrdapatsgaakidl----------------------------sgtlansaktpegqkeeLFME------------ 390
A5DMM1   224 KDmssen-----------------------------------------------------gvndVNVE------------ 238 Meyerozyma guillier...
EDK46214 281 NEneeenelyanrevynndndky---------------------ddqnddknddkndnkndnsnNNED------------ 327
Q6FWX8       --------------------------------------------------------------------------------     [Candida] glabrata ...
Q6BHQ2   232 QDeqegdd---------------------------------------------------gdetqSKLI------------ 248 Debaryomyces hansenii
ABN65850     --------------------------------------------------------------------------------    
KIS69940 515 tygDLASQLQQLQMHAQRVRN--ITDa-----DQRRKEAALVALA 552
EAY10941 184 ---NFDQALSIMMELKDQIPK--LPD------AERHKYAAAVALA 217
A0C1I4   224 ---QFAQLMHDMTKIRTSK----MTD------EERREKAANLMNQ 255 Paramecium tetraurelia
Q22XW2   389 tlnDFVKILSQMKGLKDNSQQ--LPD------EKRKENAEKFILN 425 Tetrahymena thermophila SB210
EDL43988 391 ---NFNKIVEKIRVAKMENKN--CSNh-----AARRKKAEEIIFE 425
A5DMM1   239 ---EFENVIEKLKQARIKAES--MEG------AERNEYAQQVMED 272 Meyerozyma guilliermondii ATCC 6260
EDK46214 328 ---NLEYLLTRLVLARQKAET--LSG------EERERYAAECVDD 361
Q6FWX8   221 ---DLEYLIDTLKKAKIHYQK--LSNgsdgfsEEAEQFALQMATD 260 [Candida] glabrata CBS 138
Q6BHQ2   249 ---DLDDVLTKVQQAKQNVNNndMDD------AQKEAYVNKVVKD 284 Debaryomyces hansenii
ABN65850 166 --vSVNYQTNKTNRAKEMTKG--LLD----------------VEE 190
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