1OCR


Conserved Protein Domain Family
Cyt_c_Oxidase_VIa

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cd00925: Cyt_c_Oxidase_VIa 
Click on image for an interactive view with Cn3D
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate.
Statistics
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PSSM-Id: 238465
Aligned: 14 rows
Threshold Bit Score: 119.4
Created: 11-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Subunit VIa/I interface [polypeptide binding site]
Evidence:
  • Structure:1OCR_G: Subunit interface with 1OCR_A (subunit I), defined using 3.5 A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                   #   ### #         
1OCR_G      1 ASAAKGDHGGtgARTWRFLTFGLALPSVALCTLNSWLHSGHRe-----------RPAFIPYHHLRIRTKPFSWGDGNHTF 69  cow
NP_649075 146 RTGKKPQIVAqhSKLWQKISLFGVLPMIAILTLLVFSTRSEEe-----------RLEFKNYEHMYRRTKRYWFKDGNRTA 214 fruit fly
NP_611805  24 TAAVAGEHSGg-YKVWKRLSFFVAVPAVGLCMLNAYLKHQEEhd--------kpRQEFVKYDYLRRREKRFPWGEGQKSL 94  fruit fly
O74471     42 EVQAEEEHAKrsSEFWKKVTYYIGGPALILASANAYYIYCKHqeha-----khvEDTDPGYSFENLRFKKYPWGDGSKTL 116 fission yeast
P32799     36 SLMATEKHAKdtSNMWVKISVWVALPAIALTAVNTYFVEKEHaehrehlkhvpdSEWPRDYEFMNIRSKPFFWGDGDKTL 115 baker's yeast
XP_329152  45 EREAVKQHAAetTELWRKISLYGIPPALALAGYNAYTLYNEHwehws---hlppLEERTEYPYQNIRTRNYPWGDGDKTL 121 Neurospora crassa
NP_725504   6 IRLMGNMPANt-AGLWKRVTFLLALPAIVLCAANAFTGHKHVe-----------REPFAKYEYLRRRTKRFPWGDGNRSL 73  fruit fly
Q20779     38 VTPLKQAHNA--SETWKKIFFIASIPCLALTMYAAFKDHKKHms--------heRPEHVEYAFLNVRNKPFPWSDGNHSL 107 Caenorhabditis ele...
AAH81493   15 AAASAGSHEGggARTWKILSFVLALPGVSVCMANVYLKMQAHsh---------eQPEFVPYPHLRIRTKPWPWGDGNHSL 85  zebrafish
AAH99297   24 AAAAEQEHAGa-VRTWKILSAVVALPGVAVCMLNVYLKMQHHse---------eRPEFVPYEHLRIRSKKFPWGDGQKSL 93  African clawed frog
Feature 1                    
1OCR_G     70 FHNPRVNPLPt-GYE 83  cow
NP_649075 215 FHNSHFNALPpaGYE 229 fruit fly
NP_611805  95 FHNPHVNALPd-GYE 108 fruit fly
O74471    117 FWNDKVNHLKk-DDE 130 fission yeast
P32799    116 FWNPVVNRHIe-HDD 129 baker's yeast
XP_329152 122 FWNESVNYHNr-DKV 135 Neurospora crassa
NP_725504  74 FHNAEVNALPe-GYE 87  fruit fly
Q20779    108 FHNKAEQFVPgvGFE 122 Caenorhabditis elegans
AAH81493   86 FHNPHTNALPt-GYE 99  zebrafish
AAH99297   94 FHNAHVNALPn-GYE 107 African clawed frog

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