Conserved Protein Domain Family
TT_ORF1

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pfam02956: TT_ORF1 
TT viral orf 1
TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.
Statistics
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PSSM-Id: 367272
Aligned: 58 rows
Threshold Bit Score: 278.396
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9DUH8     1 MPWgWW---RR-WRRRPrrwrrwrrwgrrRTRWGLRTRRARAAv---Rrrr--rgRVRRRArggRRYHYRRRfrrrRARR 71  Torque teno virus
BAF76121   1 MAF-WWyrrNKpWFGR-------------YKRRRTRRYKRTWRt--rRrr----pIRRRRNr--RTNRRRRRrrykVRRK 58 
BAF76081   1 MAF-WWrrrRKpWFG------------------RWRRYRRRTNykprRkrr--riYRRRRNy--RTTKGRRRrrykVRRK 57 
A4GZ97     1 MPF-WWgrrNKfWYG--------------------RNYRRKKRrfpkRrkr--rfYRRTKYr--RPARRRRRrrrkVRRK 55  Torque teno midi vi...
BAF76089   1 MPF-WWgrrRKyWWGRR------------FTRPKYRRYQr-------Rrk---rpIRRRKPr--RTYRRRYRrrkkVRRK 55 
BAF76101   1 MPF-WWarrKKpWYSN-------------WNRYRRRYKRRRWPr--rRrrr--ipYGRRR--------RRRRrkrkVRRK 54 
BAF76093   1 MPF-WWarrRKpWYGRF------------RRRYRYRPYKKRr-----Rrr---rrFTRRRNf--KASRRRRRrryeVRRK 57 
BAF76077   1 MPF-WWarrRRpWFGRY-------------KRYKTRRYRRRFRp--kRhr---ypFRRRR-------RRRRRrrykVRRK 54 
Q8QVL6     1 MRFr----yRK-WR---------------RPRRLFRSRRRRGYa--rRrwrrrawGRRRRVr--RYRRRR------GGTK 50  Torque teno canis v...
Q5ENW7     1 MAPt-----RR-WRR--------------RFGRRRRRYRKRRYgwrrRyyryrprDYRR-----RWLVRRRRrsvyRRGG 55  Torque teno virus
Q9DUH8    72 RKKI-VLTQWNPQTVRKCLIRGMFPILWCGS---GAAGKNYALHMDDYTPS--------------GGFGGSFSLTTFNLR 133 Torque teno virus
BAF76121  59 QKKI-TLKQWQPESIKKCKIKGTGQIVLGAE---GTQFRCFTVYKNEFTNPk-------------VATGGGFGVELFSLK 121
BAF76081  58 QQKI-LVKQWQPECIRKCKIKGLGTIVLGAE---GTQYRCYTDYLDEWTNPk-------------VPGGGGFGCELFTLR 120
A4GZ97    56 KKTL-IVRQWQPDSIVLCKIKGYDSIIWGAE---GTQFQCSTHEMYEYTRQk-------------YPGGGGFGVQLYSLE 118 Torque teno midi vi...
BAF76089  56 RKTL-LVRQWNPDSILTCKIKGFLDILMGAD---GNQYQCYTQNRYSMPPPk-------------HPCGGGFSVDRFTLQ 118
BAF76101  55 RQRI-IVKQWQPESIVKCEIKGLGCLVAGAQ---GRQPFCYTNSKYEYPQPk-------------APGGGGFGAELFTLQ 117
BAF76093  58 RQKI-VLKQWQPESIKKCKVKGFGCLVLGAE---GRQFYCWTNEASNYPQPk-------------APGGGGFGCEVITLE 120
BAF76077  55 KKKI-VIQQWQPESIKKCKIKGFGCLVLGSQ---GTQYLCYTNEAANYVPPk-------------SPGGGGFGCEYITLE 117
Q8QVL6    51 RQYIsSIMQWNPQHRHLCYIKGITWLCAARAdrmSWPGIKQIAATDSTRYWs-------------TILVGGCGVLTLSMD 117 Torque teno canis v...
Q5ENW7    56 RRAR-PYRLFNPKVMRRVVIRGWWPILQCLK---GQEALRYRPLQWDTERQwrvrsdfedqygylVQYGGGWGSGDVTLE 131 Torque teno virus
Q9DUH8   134 ALYDEHMKGRNRWSHTNEDLELALYFGCRFTFYRHPTTDFIVTFSNTPPMMSNQYTAPLAHPGMLMRSKYKLLLPSFKTR 213 Torque teno virus
BAF76121 122 YLYQEYLARNNIWTSTNAYRDFCRYTGSSFTFFRHPDTDFIIVYDIQPPFTINKHTYMMTHPHFLLQRKHKKILLSKSTN 201
BAF76081 121 YLYKMYLARKNIWTFSNKYKDLVRYTGTRFTFFRHPETDFILAYDIQPPFHITKWTYMSIHPQMLLLRKHKKLLLSTATK 200
A4GZ97   119 YLYDQWKLRNNIWTKTNQLKDLCRYLKCVMTFYRHQHIDFVIVYERQPPFEIDKLTYMKYHPYMLLQRKHKIILPSQTTN 198 Torque teno midi vi...
BAF76089 119 WLYDQWRLRQNIWTKPNTYKDLCRFIVAKITLYRHKTTDFIVQYSRQPPFLIDKWTYMQYHPYMLLQSKHTKIIPSEQTN 198
BAF76101 118 YLYDEWVARRNIWTKTNDYKDLVRFTGATFYLYKHPTTDFIFNYNNQPPFLLEKDFYNDLHPQMLLLAKHHRVIPSRQRK 197
BAF76093 121 YLYQQYKAHNCIFTASNHYKDPVRYTGCEIILYRHPYVDFVVTYSNQPPFSINQFTYPDIHPQNLLLRKHKKIVLSRATK 200
BAF76077 118 YLYKQWKAHNCIWTASNNYKDLCRYTGCTITLFRHKYIDFIFCYSVMPPFDINKLTYPDIQPQNLLLRQRHKLILSQASN 197
Q8QVL6   118 WFFFENLRWRNRWSHSNVGYDLARYMGTHLYFPPLADIWYIVWTDTEF-VDQPKKVMSYTHPWILLMTKKHKVIKPRKWN 196 Torque teno canis v...
Q5ENW7   132 GLYQEHLLWRNSWSKGNDGMDLVRYFGCVVYLYPLKDQDYWFWWDTDFKELYAENIKEYSQPSVMMMAKRTRIVIARERA 211 Torque teno virus
Q9DUH8   214 PGGKKTVSVRIRPPKLFNHKWYAQSDLCDVNLVQFTVTAADFMHPFGSPLTETPCVTFQV-LGD-LYNKCLNIdlpkvdt 291 Torque teno virus
BAF76121 202 PNGKLTKRIKIKPPKMLQTKWYFQEELAEFGLVAIHAAACNFRYPWLACCNENLIITLYY-LQPsFWSHTEWA------- 273
BAF76081 201 PNGKLTTRFKIRPPKQLVTKWFFQKDFAQYGLVAIAAAACNLRYPWLACCNENLIITLRY-LQPqFYHNSAWA------- 272
A4GZ97   199 PRGKLKKKKTIKPPKQMLSKWFFQQQFAKYDLLLIAAAACSLRYPRIGCCNENRMITLYC-LNTkFYQDTEWG------- 270 Torque teno midi vi...
BAF76089 199 PKGRLKKKLIIRPPKQMLSKWFFQRQFATADLFQLVTAACSLNYPRLGCCNENRTLTLYY-INPyFYQYSDWG------- 270
BAF76101 198 PLGKPYIKVKIKPPKQMLTEWFFQQDFATQGLFSIHAAAANMQWAYYNPDQQSRCLTLYS-LNIkFFANTDWS------- 269
BAF76093 201 PHGKLTVKIKIKPPKLLSTRWFFQKEMSSVPLVQLSAAACDFNYPRIGCCNVSQVMTIFF-LNPqFWGQTDWG------- 272
BAF76077 198 PKGKLRVKVKIKPPKTMQTKWYFQKQIAELPLVQLQAAACDVPFVRIGCCNPSQVSTIYF-LNPqFYYDTDWG------- 269
Q8QVL6   197 GKGK---KIFLKPPAVFNSAWYTSDKWCGAGLGRIYFSFLNPFKQIMHTNQTEQSFPFAIeLGNtDYDKPPNN------- 266 Torque teno canis v...
Q5ENW7   212 PHRRKVRKIFIPPPSRDTTQWQFQTDFCNRKLFTWAAGLIDMQKPF---------------DANgAFRNAWWL------- 269 Torque teno virus
Q9DUH8   292 vknassphtkiqvkltdnsgnPTNKEAvktlyeqlfsygqyWQTFITDFMT-ANPPKYDNGNN----KKLfnDNDyntfk 366 Torque teno virus
BAF76121 274 ---------------------QYSTSAyn----------pqGHLHPMPETL-TFKGKIDNREYtwnmSPF---------- 311
BAF76081 273 ---------------------QTTKEyn-----------pvYGTQPMKKTL-TFNYIIGNQRGtytmSNS---------- 309
A4GZ97   271 ---------------------TTKQAPhyf---------kpYATINKSMIFvSNYGGKKTEYN----IGQwiETDipg-- 314 Torque teno midi vi...
BAF76089 271 ---------------------QVKEHAnyy---------kpYNSIADLEFW-SGNTKNPTKYK----PKDeiEKAtd--- 312
BAF76101 270 ---------------------ATHTGTqmy---------fpYNAWPHTKGL-TFWTIDSKGNK----TPHs--------- 305
BAF76093 273 ---------------------QYMAHA--------------YMNIATGVAL-TGTYKDKQDKP----QNItvGDYt---- 308
BAF76077 270 ---------------------ATKNHA--------------YMYIRTGVSL-TGTYKGKDGKD----HEKiiGEWkk--- 306
Q8QVL6       --------------------------------------------------------------------------------     Torque teno canis v...
Q5ENW7   270 ---------------------EQRNDQgemkyielwgrvppQGDSELPKKK-EFSTGTDNPNY----NVQdnEEKniypi 323 Torque teno virus
Q9DUH8   367 t---tfltkKDSGYLFasynpaqvaeniknirdqnfalttgkndvfgdskaqyhnathLLDYKLGIYSPVFLHPGRS-NI 442 Torque teno virus
BAF76121 312 ---------ISDKYTN------------------------------------------SLNKDSGWFNPKVLNAYTVlKG 340
BAF76081 310 ---------DISDYDS------------------------------------------SVSISKGWFQPKILNAYEVkDN 338
A4GZ97   315 -------egNLARYYR------------------------------------------SISKEGGYFSPKILQAYQTkVK 345 Torque teno midi vi...
BAF76089 313 -------ppSTAKYYA------------------------------------------SINYNTGYFSTKVLNAFKVmVN 343
BAF76101 306 --------iKPQNYNQ------------------------------------------SVNYLQGFFSQYVLQAQKItDA 335
BAF76093 309 ---------GENPYYS------------------------------------------SINYTGGWFDTRFLNSYEIkKK 337
BAF76077 307 --------mGEAQYYE------------------------------------------SINYDTGWFNSQFLSSYKIeKT 336
Q8QVL6   267 ----------------------------------------------------------SYDFKDTNEVKKVWN------- 281 Torque teno canis v...
Q5ENW7   324 iiyvdqkdqKPRKKYCvcynktl----------------------------nrwrlgqASTLKIGNLKGLVLRQLMNqEM 375 Torque teno virus
Q9DUH8   443 Q-MW-------------TAYRDIVYN-PFLDKGEGNKVWY-QYHTKTDNKYDPTKCRYMVEDLPLWSLLHG--YADYIIS 504 Torque teno virus
BAF76121 341 DqRQs-----------lVPCGVLRYN-PYTDTGRGNKMWV-NSVLVGAWQEPKD-TDLVMEGYPLWAMLYG--YTSLLKQ 404
BAF76081 339 TvTQa-----------lTPCGVLRYN-PADDDGQGNKLWV-VNTLTYNWKIPTD-DDLILEGYPLWLMLYG--YTSFLYQ 402
A4GZ97   346 SvDYk-----------pLPIVLGRYN-PAIDDGKGNKIYL-QTIMNGHWGLPQKTPDYIIEEVPLWLGFWG--YYNYLKQ 410 Torque teno midi vi...
BAF76089 344 SkESk-----------pLPLGVARYN-PVEDDGKGNEIWV-ASIHSNAYAKPAE-DNLNFNGYPLWLAFWG--YWSYLQK 407
BAF76101 336 DdNVpakyeqysaamstLLIAAFRYN-PEEDTGQGNVVWLtSTLSNTHWERPQL-SDLVIVGKPLWLSFYG--FESFIQK 411
BAF76093 338 NtQQwl---------gyLPVGVARYN-PNEDTGEGNEVWL-TSIQKGHFDKPSKTPDFLLIGLPLWMAFYG--FWNYLEY 404
BAF76077 337 StKQpy---------ahLPIGVARYN-PDQDTGQGNEVWL-ATIFKGHYDKPTVTDDFVIRGLPLWMAFYG--YWSYLKY 403
Q8QVL6   282 -----------------TAGKKYYYR-ADWDTGDGNAIMLpNTLSPT----TPASWLLLEWDAPYWLWFWGktYQDFVSS 339 Torque teno canis v...
Q5ENW7   376 T----------------YIWKEGEYSaPFVQRWKGSRFAV-IDARKADQEN---------PKVSTWPIEGTwnTQDTVLK 429 Torque teno virus
Q9DUH8   505 QIKYGDPLVEGKVLIRCPYTRPAlYNKQSPDEgYVVYNTYFGMGKWVDGSgYIPIPERARW-MVMLKYQLDVFH------ 577 Torque teno virus
BAF76121 405 VKSKTVPFAGSMIVVKSPALYRV-FGEDTKDY-YPLIDKSFMDGKGTNNT-DPIYPKSKLW-YPALFSQRDSIS------ 474
BAF76081 403 VKADKNPFSSSLIVVKSSALQRV-FGTDTTGW-YPLIDKSFMDGKGPGNT-DPILLHRKYW-YPSLYGQRDSIS------ 472
A4GZ97   411 TR-TEAIFPLHMFVVQSKYIQTQ-QTETPNNF-WAFIDNSFIQGKNPWDS-VITYSEQKLW-FPTVAWQLKTIN------ 479 Torque teno midi vi...
BAF76089 408 IK-DKSFFALHYFVVKSPYIYTA-QTESTKNF-FPIIDWAFIQGKDPYDG-YLTSTDKSLW-YPTALRQIVTIN------ 476
BAF76101 412 TKHDKGWLLSGFYVCKCPYLKTL-SATTQTTF--AFIDLDFIQGKLPYGE-TITSQKKALW-YPNVENQVNTVT------ 480
BAF76093 405 TTKAKDIFKTHMFVVKCPAIKRL-STTITTDY-YPFFDQDFLNGNLPYGE-YLSDNEKKLW-YPTAEKQVVTIN------ 474
BAF76077 404 KTKDKGVFTNHMFVVKCPAIKPM-QSAITTDY-YPVIDLEFIQGKWPYEE-QVTENHKKLW-YPTAEHQTVTIN------ 473
Q8QVL6   340 HTPEGNPYYGQIYVKWWPITNPYd-------------------------QgPHTYPEDKEWcLMMLDPQPNFMTcnsiaa 394 Torque teno canis v...
Q5ENW7   430 DV----------------------FGINLQNQqFRAAD--FGKLTLPKSPhDLDFGHHSRF-GP---------------- 468 Torque teno virus
Q9DUH8   578 --DLVVCGPW--AYRDDEKSV-QMP--CKYKFRFKWGGT 609 Torque teno virus
BAF76121 475 --QIVNSGPYipKYNETKESTwQCN--YMYTFYFKWGGS 509
BAF76081 473 --QLVNCGPYvpKYNETKNSTwQCN--YKYTFYFKWGGH 507
A4GZ97   480 --AICESGPYvpKLDNQTYSTwELA--THYSFHFKWGGP 514 Torque teno midi virus 1 (isolate MD1-073)
BAF76089 477 --NICKLGPYvpKYENDRLSTwELP--IKYNFTFKWGGP 511
BAF76101 481 --NLVQCGPYipKYAFRDESTwELT--YKYIFYFKWGGP 515
BAF76093 475 --SLVSCGPYipRLNNQKASTwELN--YMFKFYLKWGGP 509
BAF76077 474 --NFVESGPYvpRLENQKSSTwELN--YSYKFYFKWGGP 508
Q8QVL6   395 alKIAAFGPCvyAPQDTQTSQiPINipMYYLSKWQWGGS 433 Torque teno canis virus (isolate Cf-TTV10)
Q5ENW7   469 --FCVKNEPL--EFQVYPPEPtNLW--FQYRFFFQFGGE 501 Torque teno virus
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