Conserved Protein Domain Family
bHLH_TS_Mesp
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cd18938: bHLH_TS_Mesp 
basic helix-loop-helix (bHLH) domain found in the mesoderm posterior protein (Mesp) family
Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis.
Links
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Statistics
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PSSM-Id: 381508
Aligned: 8 rows
Threshold Bit Score: 117.695
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   # ### #    #                   ####                         
Q9BRJ9        83 QRQSASEREKLRMRTLARALHELRRFLPPSVAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESL 147 human
NP_989897     68 PRQSASEREKLRMRRLAQAMHRLRHYLPPALAPAGQSLTKIETLRLATRYIAHLSALLGLSEEVL 132 chicken
AAI34251     107 KRQSASEREKLRMRDLTKALHHLRSFLPPSVAPAGQTLTKIETLRLAISYISHLSDQLRQAEVPN 171 zebrafish
BAG68482      91 QRQSASEREKLRMRNLSKALQNLRRYLPPSVAPIDKTLTKIETLQLTISYISHLSAQLGLTEEIL 155 African clawed frog
Q0VG99        82 QRQSASEREKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESL 146 human
XP_007906558 165 QRQSASEREKLRMRGLATALHNLRMYLPPSVAAPDQSLTKLQTLRLTIRYIAHLTKLLGLSDRDE 229 elephant shark
EMP36052     100 QRQSASEREKLRMRNLSKALHTLRRYLPPSVAPAGQSLTKIETLRLTIRYISHLSELLGLSEETL 164
KKF30179     217 KRQTASEREKLRMRDLTKAMHHLRAYLPPSVAPAGQTLTKIETLRLTIRYISYLSAQLGISEEAL 281

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