1F6F,1N9D


Conserved Protein Domain Family
prolactin_like

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cd10288: prolactin_like 
Click on image for an interactive view with Cn3D
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.
Statistics
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PSSM-Id: 198438
Aligned: 38 rows
Threshold Bit Score: 191.323
Created: 16-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
receptor
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding interface [polypeptide binding site]
Evidence:
  • Structure:1F6F: Ovine placental lactogen binds to the extracellular domain of the prolactin receptor, contacts at 4 A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     ###        ###    #  ##    #  ##                                    ##         #
1F6F_A      4 PPYCrnq-pgKCQIPLQSLFDRATTVANYNSKLAGEMVNRFDEQYGqgin--------------seskVINCHTSSITTP 68  sheep
P33579     31 IPACmve-dgGCWDPLREAFNSATQRAETLRNLSDQLYVEFFQNQFssrqfadlssqlirkdetvlkaGTYCHSNRAKPK 109 Norway rat
P34207     23 LWENmas-kpTVLVSTEDLYHRLVEQSHNTFIKAADVYREFDINFAkrswm-------------kdriLPLCHTASIHVP 88  Norway rat
ACY09631   10 LWEHvas-kpSGFVSIEDLYYRGVDQSHATYFLAADLYHEFDMKYFnsswi-------------kyrtLSPCHTASIHTP 75  Peromyscus poliono...
NP_082753  30 ISAChtd-eeGCMKPLVETFNNAIQRAEIILNVSEQMHQEFLHNEFssrhfthfnsqlirqdqlvlraRTYCHSTITNPS 108 house mouse
P14059     23 LLWEhvtssaSPRLSTRNLYQRVVELSHCTHDLASKVFTDFNMKFGksicr-------------qklmLYTCHTSSIPTP 89  golden hamster
Q9DAS4     31 IPACmae-ksGCWNPRMETFDSAIRKAETLRTVSKQFYVELYHNQFssgkfatltsklvrrdeivfraASHCHSTLTNPP 109 house mouse
NP_112606  23 LWISvtp-tpYDQMSNEELYDNLLSCSHRTHVVARKMYKILDLNVAer------------------rcFKNKRNNTCHTT 83  Norway rat
NP_034218  30 IPECqtg-enGCSDPLVITFKNALQRAEVINILADKMHEEFYHNPFsagqfetlvsrmyrrdeevlraRNHCHSNVTNPP 108 house mouse
NP_038794  23 LWVYvta-trYDRKSNEEIYDNLLSSSRHIHRVAKKMYKILDSKLT----------------------EGVCFRNKNTKM 79  house mouse
Feature 1           ##                                                #  #  ##                
1F6F_A     69 ns-kaEAINTEDKILFKLVISLLHSWDEPLHHAVTELAnskgtsPALLTKAQEIKEKAKVLVDGVEVIQKRIh---pGEK 144 sheep
P33579    110 s----RGVNIDIEEYLKMSINFCGFMDQPLFHLVIELSamegvpETILSKAKDLEENNRQLLDDLRWILTKVfp--tAEI 183 Norway rat
P34207     89 en-reEVHEIKTEDLLRSIINISVSWKEPLKHFVSAVTdlpgasASMRKKAVDMKDKNLIILEGLQKIFNRTqtkveENE 167 Norway rat
ACY09631   76 qs-reEAHETKTEDLLKTMINISHAWEEPLKLLISAVPtlpgasDKMLKRANVVRNRTRVLQEGMKIILSRSq---kKVE 151 Peromyscus poliono...
NP_082753 109 ni-gpEYKNIKTKKYLKMLINFVGAWISPLYHLVIELSamndvpESILSKANEIEENNRELLNDLRWILTKVyp--tAKM 185 house mouse
P14059     90 en-reQVHQTNSEDLLKVTISVLQAWEEPVKHMVAAVAalpgtsDAMLSRAKELEERVLGLLEGLKIILNRIh---pGAV 165 golden hamster
Q9DAS4    110 nk-giQYITIEIPEYLKTLINYVGAWISPLFHLVIELSamkdvpETILSKAKEIEENNRQILRDLRWIITEVyp--tSKK 186 house mouse
NP_112606  84 s----THTAKTNEDLLKVIISVSNAWIYPLKMLIPAVLthlgsyDGMMARAIELNYGNQKILEGAKFLLSRIq---pGIE 156 Norway rat
NP_034218 109 ah-gpEHENLKTKRYLKTMINFMGAWITPVYYLVEVLSdmqnvpESIYSKAQEIELKFREIHDDLTWVLKKVyp--kVTF 185 house mouse
NP_038794  80 cqtisTHSVKKNEDLLKVIINVSNFWTYPLKMLIPAVLthldsdDGMMTRAVELNYGNKVVLEGAKALLSRIqp--gIEE 157 house mouse
Feature 1                                     ##  ## ### ##  #       #
1F6F_A    145 NEPYPVWSEQssltsqDENVRRVAFYRLFHCLHRDSSKIYTYLRILKCRL---TSC 197 sheep
P33579    184 KEEFPSWDYLsflkssNKNHKFLAIFNLSSCLDYDTQVHYTLSQILNCLIt-gKDC 238 Norway rat
P34207    168 NFDYPAWSGLkdlqssDEDTHLFAIYNLCRCFKSDIHKIDTYLKVLRCRVvfkNEC 223 Norway rat
ACY09631  152 NDPYPAWSGLadlqspDEDTRLFTLYNLVRCLKRDTHKIDAYFKLLRCREvfkNEC 207 Peromyscus polionotus subgriseus
NP_082753 186 KKLFPTWEHLpsikstDKNYQFLAIFNLSHCLRVDIFYTKFHLRTLKCRIt-gKDC 240 house mouse
P14059    166 ENDYTFWSGWsdlqssDEATRNIAFYTMGRCLRRDTHKVDNYLKVLKCRDihnNNC 221 golden hamster
Q9DAS4    187 KEIFPSWELLsflkssSRNSKFLAMFNLSHCLEYDTQFFLFHLRILKCRIt-gKDC 241 house mouse
NP_112606 157 ENDYPVWSSLkelrssNKSIHLFAFCKFFYCLRKDTKKIKDYLQILRPNIi-kNKW 211 Norway rat
NP_034218 186 WEKSIIWEYLpglrstDTSKKFLAMFNLSHCLRVDIFFIKYHLSALMCRIt-gQDC 240 house mouse
NP_038794 158 NNEPDRWSDLrelrssKKSKHLLAFCKFFYCLRKDTKMVTCYLRALKHGKi-kTIC 212 house mouse

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