Conserved Protein Domain Family
Npa1

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pfam11707: Npa1 
Ribosome 60S biogenesis N-terminal
Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.
Statistics
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PSSM-Id: 463325
Aligned: 113 rows
Threshold Bit Score: 177.042
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC73026      120 AASIFSTWELADRQDLPTLLHLPIFCLAQSL---ALLSvH--------YPTHTLGSNIIERILSPnepWLAMLHNYISNl 188 
XP_022519738   75 CCEIVELLEGESQSVTE-LMLIFRSLELILL---RTASdL--------SHFSMVGTTVVKKILST---HAKLLQSSLCS- 138 
4_pfamImport    1 CAEMFKLLDGEKRSESE-MLLVFQTLEAILL---RTASdL--------SHFSVVGMNIVKKLIHG---YMQLLYGALQS- 64  
XP_018873302   78 CVEIFQLLSGEKRPESE-MMLIFQVFEAILL---RTASdL--------SHFHVVGTNIVKKLMNN---HMKLICESLYA- 141 
Q54RN6        112 MTEIFKIWDLCIDKYQ--IYQNVYSLLLEFIailITINdD--------PSLSHYSKILADKILSNkfqDLLKLINNYTD- 180  Dictyostelium...
EGC40124      106 LTELFTIWDTCIDKYQ--VYQTCYALLLEFLaiiITLNdD--------PALQFQTRILADRIITNrflDLQKIINSYSD- 174 
XP_003056485   25 FEDILALWDAYHNTNTQRVCVPLMLLVADLL---RHTPeDrtae---rgfiHLQLDGLARSILQR---RMRAVYSHLNS- 94  
EEF29298       86 FSELFAALKLREGKS---GTHYIFKLISVIL---GHPEgKfipndkgrIGISVGLDKFARSFLEE---KLDFVYKDLVS- 155 
XP_010644440   95 FSELQDAWKRWQGKP---GMSYILSLISAIL---SHPDgIyrpndtrrIAISRIIDKFARSIVEE---KLEDIYKELNS- 164 
XP_023207562   73 CAEIFKLLEAEKPLETE-MMLIFGSLEVILL---RTASdL--------SHFNMVGNVIVKKIASN---YMKLLQGsfhs- 136  southern plat...
GAC73026      189 ggakfasskqrdsrtSKgsDVA-ALASLIL---LREVSTfAKGRYAVKLFDSFNWSMKVLPHIFsmRRRtn-rKskAAKK 263 
XP_022519738  139 ---------------VN--HQF-VRQCLSL---LSAMVS-QGANSAREVFSILVFS-KSLNSLA--RQR----------- 182 
4_pfamImport   65 ---------------ESy--SFqSGVCLSLgpsFKLQVS-PPSENRASVTQRLLHVMNTLFFFF----F----------- 111 
XP_018873302  142 ---------------SG--YRL-ARACLSL---MTAMVT-QGPEAARDVCSHFDLNKKTLYTLV--TKR----------- 186 
Q54RN6        181 ---------------ET--VNL-TLNCFRL---LSSIVP-LSLKIAKSIQTNIDFSSQGFQKAM---------------- 222  Dictyostelium...
EGC40124      175 ---------------ET--VNL-TLNCYRL---LSSIVP-LSIKIAKSLQTNIDFSSNAFQEAM---------------- 216 
XP_003056485   95 ---------------SI--RIR-QKCAMTL---CISITA-RSRQLAWDVFRNLDFTLAAFAKLS--KPPryqiNctWDST 150 
EEF29298      156 ---------------KD--KKR-QNAALSV---MDSVVR-RGSGLASEVAKKFDFKLKGFSKLS--EYKplknEnkRRRS 211 
XP_010644440  165 ---------------KE--GKH-QKAALLL---MASIVR-RSSSLASEVAKSFNFKFPVFPKLA--EYK---------LK 211 
XP_023207562  137 -----------------lnhgF-VRQCLNL---LSAMVS-QGAEAAREVFSHVQI--KTLFGLA--KRK----------- 179  southern plat...
GAC73026      264 PSVALDVslrrPDIRTLYILFLLSFLQQSySNTLKIRLLDLgRDFLPAMLKGL-PQDPPDVVQTILLHLHEDLVKDQ-RI 341 
XP_022519738  183 --DRTGR----LDVRMAYVQFALSFLMCG-DSSIVGKILDA-KDFLCDILSTGlKEDRISIVSLILSTLQTKVVHNP-AI 253 
4_pfamImport  112 --PKQGR----PDVRVAFIQFALSFLIAG-DNAIIGQVLEL-KDFLMDVFSSGlKEDRISAVSILLSTLKTKVKISL-SL 182 
XP_018873302  187 --DSKGV----YDVRQAYVQFALSFLIAG-DDSTIVQVLEV-KEFIPCIFSSGiKEDRISTINILLSTLKTKVVHNK-NI 257 
Q54RN6        223 --NDISIngayLGTRPYVLRFLLSFLKHH-NIKLSEFILEN-DQLLVKYCQKL-QLDHHNVILDLIESLEVNVLKVS-NV 296  Dictyostelium...
EGC40124      217 --TDIPSngayLGTRPYVLRFLLSFLKHH-NLKLSEFILES-EYLLSKYCHKI-QLDHHNVILDLIESLETNILKVD-II 290 
XP_003056485  151 TETRSSHdasaLPTRHIFVEFVMVLLSSG-DVSLLRCVLTQ-KVLLGNVLRHL-ASDPVPLASRVLRVMCDNVIVDGsGV 227 
EEF29298      212 TDDEKRK----YITRKAFIAFAMSFLEVG-KPGLLRWVLQQ-REVYSDILRGL-GEDDDETVMYVLSILRDRVLTEEsLL 284 
XP_010644440  212 QVEKKRK----HSTRKSFIGFAMSFLEVG-KPGLLRWILQQ-KEMYSGVLRGL-GSDDVETVVYVLSTLKDRVLIPEsLV 284 
XP_023207562  180 --DKRGK----PDVRLAFIQFVLSFLVSG-DSAIIGQVLEV-KELLPQILNTGlKEDRMSTVNLILSTLKTRIVLNK-AI 250  southern plat...
GAC73026      342 PRSKKVEFWNEWACGC--VVQLYPREEEhvli-------hadTdav----enPSVAELAHHFLLSICTNPGFGICY---- 404 
XP_022519738  254 NKSQKLRFFSAATLAQ--IASLYKWNGIvdss-------tvdSqge----gkLLVRELVHNFLLDLCCSHKHGIGF---- 316 
4_pfamImport  183 VKLSWKSFASGQQILHskLASVLLFYGVsgtg-------vedPkea----gkVMVRELVHSFLLDLCCSLRHGINFyd-- 249 
XP_018873302  258 TKTQKVRFFTGQLLNH--IASLYNWNGItdvn-------pedVkvsaeeagkTMVRELVHNFLMDLCCSLKHGINF---- 324 
Q54RN6        297 SKILKIKFFSTSFLSK--IGLIFSKDDIge-----------------------dCRQSIFKFLSILCCSSTHGIIS---- 347  Dictyostelium...
EGC40124      291 PKKLKIKFFSPSFLSK--IGLVFSKDDIge-----------------------eSRQSIYKFLTTLCCSPIHGICS---- 341 
XP_003056485  228 SVRLQAALFSDRVLGQ--IVAISGRQAEavsg-------tkgIsk------aACAAELAHSLLLRLCTDPVHGFRR---- 288 
EEF29298      285 PPALRSVLFGSVVLEQ--LADISEKRYGg------------------------pTANLAHNVLLMVCTDPCNGLMPdlkr 338 
XP_010644440  285 PPGLRSVLFGSVTLEQ--LVSISGREDGg------------------------pASELAHRVLVMVCTDPCNGLMPdlkr 338 
XP_023207562  251 SKTQKVRFFTPAVLAN--IASLYKWNGIvdatadddtmaedsDaa-----giSVVRDLVHRFLVDLCCSRKHGISF---- 319  southern plat...
GAC73026      405 -P-DR-GWYPRkasargDTdeaagtgkaggaangldkdsfsfemgstqKAKPTSIsiggSI--------YNKVLSGVLRQ 473 
XP_022519738  317 -HdPSlGTATRa---------------------------------------------------------GNLVLLQFVVG 338 
4_pfamImport  250 ----------------------------------------------------------aSLgtdgrsvpGNLVLLRFILG 271 
XP_018873302  325 -YdASlGTFGRg---------------------------------------------------------GNLTLLHFLLG 346 
Q54RN6        348 -SdPKwTWFRDnen----------------------------------------------------psfENKSLVSLISE 374  Dictyostelium...
EGC40124      342 -SdPKwTWFREndl----------------------------------------------------psfENKSIVSLITE 368 
XP_003056485  289 -EnAS-GRFVGakeeisLGsmseghlqargavksgkassitkieysspVINAITTgyarEVd------eRNETVLRLLRK 360 
EEF29298      339 rPnALkG--------------------------------------------------------------NSKRLFQLMKK 356 
XP_010644440  339 hPyPLrG--------------------------------------------------------------NPKRLLGLMKK 356 
XP_023207562  320 -H-DT------------------------------------------------------SFgts--grpGNLVLLQFLVG 341  southern plat...
GAC73026      474 LA-VAEDLRQQELALSILKACPELVGpYL--ESscagLSVDPRPSSRWLCN 521 
XP_022519738  339 LKqATEDELVCELLVSILKCSPDILPrYFkeTN----FSFTPRVAGAWLDS 385 
4_pfamImport  272 LKtATEDELVAELLVSILKVCPDLLHrFFkeTK----YSFVPRLKSAWLDN 318 
XP_018873302  347 LKtAADDDLVADLVVNILKVCPDLLNkYFkeVT----FSFIPRAKSTWLNN 393 
Q54RN6        375 LN-PIAYQTHQTLFIKIINSCPDLFTsYLkkLG-----TCEVSLSLNWLNR 419  Dictyostelium discoideum AX4
EGC40124      369 LN-PIAYQTHQSLFIKIINACPDLFTsYLkkLG-----SCEVSLSLNWLNR 413 
XP_003056485  361 LK-PTESRRHAEMLLEVCSKQPNIAAsYIphAT----YSLEPRLSWSWITA 406 
EEF29298      357 LK-AKEV-FHRELLLAIVRGRPSLGSaYLeeFP----YNLEDFASPNWCST 401 
XP_010644440  357 LK-ATEVAYHRDLLLSIVKGRPSFCSaYMdeFP----YKLEDHTSSTWFAA 402 
XP_023207562  342 LKqATEDELVAELVVNILKESPDILSrFFkeTQ----YSYTPRIRSAWHDN 388  southern platyfish
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