Conserved Protein Domain Family
MSC
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pfam09402: MSC (this model, PSSM-Id:401378 is obsolete and has been replaced by 430586)
Man1-Src1p-C-terminal domain
MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation. The C terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands.
Links
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Statistics
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PSSM-Id: 401378
Aligned: 111 rows
Threshold Bit Score: 186.728
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EKM55391     397 LLGTSVLTALGmYKTESASIGFCETGK-------------------------NTNDILEGmkvrrtaiqecnrenrttlf 451  Phanerochaete ...
XP_003959028 289 IIALPILFALW-YREQRIRVGYCGKELpliplas------------grtdnvFFQKIDSL-------------------- 335  Kazachstania a...
CCK69393     376 AIASVVLWGVW-YREQRIAVGFCHHELplkklcpdrliqiyqtfvldlsffdSI-------------------------- 428  Kazachstania n...
Q6FMP6       278 VIVLPILFFLW-YREQKIRVGFCGHEL-------------------------PVAKFAPYansnkvw------------- 318  [Candida] glab...
XP_003687595 251 SIILLCFFTLW-YREVCINIGYCGKELayppflktsitdkvl-------------------------------------- 291  Tetrapisispora...
EJT44944     331 SILLPILFGLW-YREQRIRIGYCGHEEpiksla--------------fsafsQTARVDEF-------------------- 375  Saccharomyces ...
XP_003676977 487 MFAVPVVFALW-YREEQIAIGYCNTRYelnntgttseh------------------------------------------ 523  Naumovozyma ca...
XP_003671605 567 LFAIPIVFALW-YREERILVGYCGHESvqsils-------------lsiespFFSCLDTI-------------------- 612  Naumovozyma da...
XP_004180860 510 sILLPILFLIW-YREQKLATGYCGYSL-------------------------SPPSIIHSksnvfsqm------------ 551  Tetrapisispora...
XP_011273519 625 FFTILIISSLW-YREQRILIGYCGLEIndktfp--------------ntdneILIKIDEFl------------------- 670  Wickerhamomyce...

EKM55391     452 lahpdaaqdvpspqptqvatgtegsnvilseacpPPPLLPlprpeTCQLCPEHASCT-PTTVTCENGYLLR--PHPLLsf 528  Phanerochaete ...
XP_003959028 336 ----------------------------------LKFVKP-----KCLPCPSNAKCYsLMDMDCYPQFKRY--SSIFK-- 372  Kazachstania a...
CCK69393     429 ----------------------------------LEKYAP-----KCIDCPENAMCFsHMRLICDAGYIAM--SSWKS-- 465  Kazachstania n...
Q6FMP6       319 ----------------------------asvdktLERFLP-----KCKLCPEGAICKtHLQMSCKDGYVLR--KSWWN-- 361  [Candida] glab...
XP_003687595 292 --------------------nnglfekydiksklSDLIIP-----DCTPCPDNAICYsSMKSVCNKGYVPE--NSFYN-- 342  Tetrapisispora...
EJT44944     376 ----------------------------------LQAYAP-----NCLECPEHATCSsLMNIECESGYELK--SSILE-- 412  Saccharomyces ...
XP_003676977 524 ------------------------helwnilgtyLEATKP-----KCIPCPEHASCYaNMQLICDNNYERT--TNYLS-- 570  Naumovozyma ca...
XP_003671605 613 ----------------------------------LSPFKP-----KCLPCPANAICHsNLATECIPHYETSafSSLLS-- 651  Naumovozyma da...
XP_004180860 552 --------------------------ifkfdawlKQKFSP-----SCVSCPKNALYTfNMNANCQSGFEFT--YSFFN-- 596  Tetrapisispora...
XP_011273519 671 ----------------------------------DQNLKP-----TCLEAPENSIALpYLQIKCKPDYIVY--QPWYK-- 707  Wickerhamomyce...

EKM55391     529 lpipsslrptdnrnaytnpslavaptygnkspldlaytglslimdgLPGLGPVafPPRCVE-DPMRKRHIGAMGRTIDSK 607  Phanerochaete ...
XP_003959028 373 ----------------------------------------------LNGLIPL--TDYCII-DNTKEKLVNKMVNYMLKK 403  Kazachstania a...
CCK69393     466 ----------------------------------------------LNGLLPI--NGHCIK-DMKKDEILKDIFQSCLED 496  Kazachstania n...
Q6FMP6       362 ----------------------------------------------LESLLPL--ADKCIT--KRKAANKKTPLLFALDL 391  [Candida] glab...
XP_003687595 343 ----------------------------------------------LYGLLPL--PIKCSK-DKTEEKLVQDILNGVLYD 373  Tetrapisispora...
EJT44944     413 ----------------------------------------------TYGVIPF--SKYCVK-DESKEKEVDELVWKVSEY 443  Saccharomyces ...
XP_003676977 571 ----------------------------------------------LFKLIPL--ADSC---HEASAERVLEIANHLTDV 599  Naumovozyma ca...
XP_003671605 652 ----------------------------------------------LYGLIPL--PPSCEPiETEKSKELNQITSELLSV 683  Naumovozyma da...
XP_004180860 597 ----------------------------------------------FYGLIPM--RRHCEK-MKLDTKKLNKILTNIMAI 627  Tetrapisispora...
XP_011273519 708 ----------------------------------------------IHGLLPF--SDYCIK-DTKKELIIKEVVSKSLEL 738  Wickerhamomyce...

EKM55391     608 LAAERGRRLCDGARPDDkpgkvaqeakKWGVEVDALKESIRKdvikkSKSPS-QLLSTLDDT---FNEAIQQLVEWGGVF 683  Phanerochaete ...
XP_003959028 404 LRSKNGSVDCGTAKSDL----------ISGMIEDDLYDSIYE-----KFSNK-YSDDEFEEL---WSEALDKLEDLKEI- 463  Kazachstania a...
CCK69393     497 LRMENAEKNCGEGENNL----------ESGISSSILFEKHFRkviedQN----WSTYEGKQL---WGTVLDKLKGMPEVS 559  Kazachstania n...
Q6FMP6       392 LRTQNANTHCGSTLPDNy---------QAGMLEKDLFNNVYE-----EYRDM-MTKESFEKE---WAVLSNSLKRLPEIY 453  [Candida] glab...
XP_003687595 374 LRLKNSRVRCGDGETDE----------STGLIEKNMFDSFVS-------QKAwLSEKQRQRI---WRKVMLQLKKYPEIK 433  Tetrapisispora...
EJT44944     444 LRKKNAQVDCGEGQNLF----------ESGETETKLYEIFSR-----SRPSW-ENQADFNEH---CRNVIEKLRHMDEIV 504  Saccharomyces ...
XP_003676977 600 LRKQNARIQCGKGANDL----------KSGLSEKHIFNLLSL-------WYTwVHEENFDDL---WLNVQSELKKKPDIS 659  Naumovozyma ca...
XP_003671605 684 LHHQNAHLECGNSADNG----------LSGMNEGELYNEFMS-----YRSPW-INKEQYSEL---WVRVKAKLKNSKDIE 744  Naumovozyma da...
XP_004180860 628 LTKKNTEaiyf------------lnsnYVTFSKDDLYEFLLGryfndGK-----------EVdiyFETVVKSLKNNPDIV 684  Tetrapisispora...
XP_011273519 739 LRIKNANVQCGDCTNDE----------IVGITNDELYEFFFN-----SKSNS-ITDEEFNEL---WVNVLKDLQNEPEIT 799  Wickerhamomyce...

EKM55391     684 IGEDEQG----------------------------HRYVAHRTPKLDMMCAVK-------VKALEYRDMWWKQ---AFGS 725  Phanerochaete ...
XP_003959028 464 --KISVTdiig--------------------pdqmKIIRSTSKKSIGLKCRLGspllknfRDVLSTCIKLRYV---TAII 518  Kazachstania a...
CCK69393     560 WSYREDElv-------------------------gINLRSHSRKYIGFGCRYG-------RHIKNTVMTYQHH---LIGL 604  Kazachstania n...
Q6FMP6       454 YKTFVSKnvagn-------------------ieniQLFRSLSKQNVSYFCGIF-----------KLLKEFPIEknvLFVA 503  [Candida] glab...
XP_003687595 434 LVNLYKKrldaddseaevvn---dhvfsiaekmshNLLRSTSKNFVPFYCGKS-----------DIIISSNYIkptLTIL 499  Tetrapisispora...
EJT44944     505 WLPLDFEtgeeihf---------------kpnnttCVYRSTSKKWVKLPCHLG-------ADIRKGLRKYGVS---VLIT 559  Saccharomyces ...
XP_003676977 660 FSVVPVEnst----------------------nstLWLRSNSRRYINLKCFFQ---------PTENIMKQSRY---IFVL 705  Naumovozyma ca...
XP_003671605 745 WHYIHPYsngslptn------------stsnteivTQFRSHSKKYVRVTCSLP---------KIEILPKLEEAlysVAFL 803  Naumovozyma da...
XP_004180860 685 WKEVEDLsgsk--------------------ydkhNNVTISAVEEVFYSTKTN-------FPGFNYLFKNKLApflLMLI 737  Tetrapisispora...
XP_011273519 800 LRYTDIVdsnstqdnlstnevedetddiqqttersIIFRSNSKLKLSIKCKFQ-------KEIYDNFEKNKKI---LISF 869  Wickerhamomyce...

EKM55391     726 ----LAL--LLSA----WMAKHRRKQRLEDRERVTVLVDTVYDMLRNQELVHHTDPvsaprpYVPSTQLRDAVLQGE-HS 794  Phanerochaete ...
XP_003959028 519 ----AIF--GIIS----FFTFKYTRKCLTRRKLITFYTEKAIEKLK--KAKRTRNNs----sGLDTLQIRDDVLSEV-TN 581  Kazachstania a...
CCK69393     605 ----IVA--LLVF----IIVKKRVKSYKIEQDKIRLYTENAIDRLKKSKLENNDPP------FVHTVQLRDVILADV-AD 667  Kazachstania n...
Q6FMP6       504 ----LTI--FSCTvtleIILQKLWKCQNRENAFVEKSTEKALEKLREASRDpe-------vkFLDTVQLREFLLSET-TN 569  [Candida] glab...
XP_003687595 500 ----VFLfsIVVL----CFLNKLIVNKLNDQTKCSVYIERIVEILKEIKENNKPQS------FLTSNQLKEIIFKDEvEN 565  Tetrapisispora...
EJT44944     560 ----LIV--ILFI----KKIQSTLDDYVQGEQIIEQFVKEATDRLKSAKKNEDEEP------FLTTVQLRTILLRDI-PN 622  Saccharomyces ...
XP_003676977 706 ----LLL--IFIIyglwNYVHGIFERRHGDAANIEQLFVTTLRLLQDAKKEkd-------mpFVNTLQIKDQIFKDI-KD 771  Naumovozyma ca...
XP_003671605 804 ----ILL--FITI----KVAKNEWTRRLKEQSYIRNLIKIAIQELKVNKREQIESP------FVNVLTIKSKLLNDI-SD 866  Naumovozyma da...
XP_004180860 738 lsplLYI--IITI----FLITLVSYKTYLTRKKVQHIVQRVVIDLKSA---KRSDNsl---dYRNTTQIKELIFEEE-KD 804  Tetrapisispora...
XP_011273519 870 ----LTI--SILI----LIGYNKIKSIQKRNLKIKEISDIILIKLQKQSKNSQLDStgltkrFLSNIQLRDELLINY-HN 938  Wickerhamomyce...

EKM55391     795 VATRQRLWKEVERIV--EANTNVRTNLEEv-AGGDEMRVWRWVGS 836  Phanerochaete carnosa HHB-10118-sp
XP_003959028 582 LKDKNYFWSQMMKRMd-ADEKNIASTQIE--VHGEIIKYWNWIGN 623  Kazachstania africana CBS 2517
CCK69393     668 LHERNEIWGSMVKRM--DKDKNVLSSQME--IHGEIMRCWMWTGD 708  Kazachstania naganishii CBS 8797
Q6FMP6       570 LKKKNQLWDKISSKL--LENENVEKRQME--LYGEVLGIWEWNd- 609  [Candida] glabrata
XP_003687595 566 VEEQNRIWKKISNKL---ENSDIPVTSTQleLHGEILRSYEfelp 607  Tetrapisispora phaffii CBS 4417
EJT44944     623 IKEQNSLWARTKDKIikEYSENIELYLLE--ENGEIMTCLEWNd- 664  Saccharomyces kudriavzevii IFO 1802
XP_003676977 772 MRTRLNLWKKVSAKLe-EDKKQIKVYHLE--VDGEIMECWEWIDP 813  Naumovozyma castellii CBS 4309
XP_003671605 867 ADYKNYVWKEIKQKI--EQNPNVLTYHTE--LQGEIMKCWEWVGQ 907  Naumovozyma dairenensis CBS 421
XP_004180860 805 MKTLRNLWKLIRLEL--SNYLEVTNYIKE--QDGEIIECWEWdsn 845  Tetrapisispora blattae CBS 6284
XP_011273519 939 -KEKFKIWELILNNL--EKNSNIRILTKE--IHGEIVKVLEWIGd 978  Wickerhamomyces ciferrii
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