2EVA,3DTC,4F0F,3PPZ,3LB7,2Y4I,3KMW,2NRY,3S95,3UIM


Conserved Protein Domain Family
STKc_MAP3K-like
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cd13999: STKc_MAP3K-like 
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Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.
Links
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Statistics
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PSSM-Id: 270901
Aligned: 72 rows
Threshold Bit Score: 244.369
Created: 17-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #####   #            # #                                           #            
2EVA_A     16 VGRGAFGVVCKAKWr--aKDVAIKQIEsese-----------------rkafIVELRQLSRVnhPNIVKLYGACln---- 72   human
3DTC_A     15 IGIGGFGKVYRAFWi--gDEVAVKAARhdpdedi-----------sqtienvRQEAKLFAMLkhPNIIALRGVClke--- 78   human
3LB7_A     44 IGSGSFGTVYKGKWh---GDVAVKILKvvdptp-------------eqfqafRNEVAVLRKTrhVNILLFMGYMtk---- 103  human
2Y4I_B     41 IGKGRFGQVYHGRWh---GEVAIRLIDierdne-------------dqlkafKREVMAYRQTrhENVVLFMGACmsp--- 101  human
2NRY_A     39 MGEGGFGVVYKGYVn--nTTVAVKKLAamvditt-----------eelkqqfDQEIKVMAKCqhENLVELLGFSsdg--- 102  human
O43283    174 LGSGAQGAVFLGKFr--aEEVAIKKVReq----------------------nETDIKHLRKLkhPNIIAFKGVCtqa--- 226  human
Q9NYL2     22 CGGGSFGSVYRAKWisqdKEVAVKKLLk-----------------------iEKEAEILSVLshRNIIQFYGVIlep--- 75   human
AAU87044   52 LGSGAFGTVYHGKWr--gSDVAIKRIKkscftgrss-------elerlahefWREAEILSKLhhPNVVAFYGVVkdgp-- 120  Zea mays
EAL20321  721 IGSGGFKDVYVGKFr--gRKVAISEFRshls------------------emdIRELKLLAEFshPNIVRFVSPFlsseri 780  Cryptococcus neof...
CAL57066  527 IGRGAFGEVFRGKFr--gTDVAIKRLCvldgsaaapmmtseetsddrglaefKRELSFLSRLrhRHIVQFIGAAtep--- 601  Ostreococcus tauri

Feature 1                            ####   # #                                          # # #
2EVA_A     73 ------------------pVCLVMEYAeggSLYNVLhgaeplpyyTAAHAMSWCLQCSQGVAYLHsmqpKALIHRDLKPP 134  human
3DTC_A     79 -----------------pnLCLVMEFArggPLNRVLsgk----riPPDILVNWAVQIARGMNYLHdeaiVPIIHRDLKSS 137  human
3LB7_A    104 -----------------dnLAIVTQWCegsSLYKHLhvqe--tkfQMFQLIDIARQTAQGMDYLHa---KNIIHRDMKSN 161  human
2Y4I_B    102 -----------------phLAIITSLCkgrTLYSVVrdak--ivlDVNKTRQIAQEIVKGMGYLHa---KGILHKDLKSK 159  human
2NRY_A    103 -----------------ddLCLVYVYMpngSLLDRLscldgtpplSWHMRCKIAQGAANGINFLHe---NHHIHRDIKSA 162  human
O43283    227 -----------------pcYCIIMEYCahgQLYEVLrag---rkiTPRLLVDWSTGIASGMNYLHl---HKIIHRDLKSP 283  human
Q9NYL2     76 -----------------pnYGIVTEYAslgSLYDYInsnr-seemDMDHIMTWATDVAKGMHYLHmeapVKVIHRDLKSR 137  human
AAU87044  121 ----------------ggtLATVTEFMvngSLRHVLqrkd--kylDRRKRLIIAMDAAFGLEYLHs---KNIVHVDLKCD 179  Zea mays
EAL20321  781 iayieqrgicipedsthvpCMLVSELCengDLFDYIrnv---pcpTLKRLLSLMLDIARGLEYLHtr-kPSIIHRDCKSS 856  Cryptococcus neof...
CAL57066  602 -----------------pnLCIVMDYCdkgSLYAYLhnqs--ktlSAFKVLKWMSEAAKGLVYLHa---SGIIHRDVKSG 659  Ostreococcus tauri

Feature 1     # #                  #  #                    ####                               
2EVA_A    135 NLLLVag-------gTVLKICDFGTACDIqthm--------tnnKGSAAWMAPEVFegs---------nySEKCDVFSWG 190  human
3DTC_A    138 NILILqkvengdlsnKILKITDFGLAREWhrtt-------kmsaAGAYAWMAPEVIras---------mfSKGSDVWSYG 201  human
3LB7_A    162 NIFLHe--------gLTVKIGDFGLATVKsrwsgs---qqveqpTGSVLWMAPEVIrmqd------nnpfSFQSDVYSYG 224  human
2Y4I_B    160 NVFYDn---------GKVVITDFGLFSISgvlqagrredklriqNGWLCHLAPEIIrqlspdteedklpfSKHSDVFALG 230  human
2NRY_A    163 NILLDe--------aFTAKISDFGLARASekfaqt---vmxsriVGTTAYMAPEALrg----------eiTPKSDIYSFG 221  human
O43283    284 NVLVTh--------tDAVKISDFGTSKELsdkst------kmsfAGTVAWMAPEVIrne---------pvSEKVDIWSFG 340  human
Q9NYL2    138 NVVIAa--------dGVLKICDFGASRFHnhtt-------hmslVGTFPWMAPEVIqsl---------pvSETCDTYSYG 193  human
AAU87044  180 NLLVNlkd----qsrPICKVGDFGLSKIKrntla------sggvRGTLPWMAPELLngss-------nkvSEKVDVFSFG 242  Zea mays
EAL20321  857 NILINr--------sGVAKVGDFGLARVKnstrs-----mirslVGTVNWQAPELWhpt--------pryDYKVDVFSAG 915  Cryptococcus neof...
CAL57066  660 NLFIDd--------gGSIKIGDFGLSKFHsgasts---ggmmsvVGTYQFMAPELLngq--------pryTSAVDVYSFG 720  Ostreococcus tauri

Feature 1                                                                                     
2EVA_A    191 IILWEVitrrkpfdeiggpafri------------mwavhngtrppliknlpKPIESLMTRcwskdPSQRPSmeEIVKIM 258  human
3DTC_A    202 VLLWELltgevpfrgidglavay-------------gvamnklalpipstcpEPFAKLMEDcwnpdPHSRPSftNILDQL 268  human
3LB7_A    225 IVLYELmtgelpyshinnrdqiifm---------vgrgyaspdlsklykncpKAMKRLVADcvkkvKEERPLfpQILSSI 295  human
2Y4I_B    231 TIWYELharewpfktqpaeaiiw-------------qmgtgmkpnlsqigmgKEISDILLFcwafeQEERPTftKLMDML 297  human
2NRY_A    222 VVLLEIitglpavdehrepqllldikeeiedeektiedyidkkmndadstsvEAMYSVASQclhekKNKRPDikKVQQLL 301  human
O43283    341 VVLWELltgeipykdvdssaiiw-------------gvgsnslhlpvpstcpDGFKILMKQtwqskPRNRPSfrQTLMHL 407  human
Q9NYL2    194 VVLWEMltrevpfkgleglqvaw-------------lvveknerltipsscpRSFAELLHQcweadAKKRPSfkQIISIL 260  human
AAU87044  243 IVMWEIltgeepyanmhygaiig-------------givnntlrphvpascdPEWRRLMEQcwapdPAQRPAftEIAGRL 309  Zea mays
EAL20321  916 MVYWEMmsgwigekkypweghnehyiy-----davgtkhrrppvtgmrkhwgSEPVNLMERmwhqdPAERPTmtDVVHDL 990  Cryptococcus neof...
CAL57066  721 IVMWECltreepfvglspmqivaal--------lrgerpgdgatetndmelpEEYLERMRAcwdaePGVRPAmkDVAPEL 792  Ostreococcus tauri

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