Conserved Protein Domain Family
HSPA12A_like_NBD
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cd11735: HSPA12A_like_NBD (this model, PSSM-Id:212685 is obsolete and has been replaced by 466841)
Nucleotide-binding domain of HSPA12A and similar proteins
HSPA12A (also known as 70-kDa heat shock protein-12A) belongs to the heat shock protein 70 (HSP70) family of chaperones that assist in protein folding and assembly, and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). No co-chaperones have yet been identified for HSPA12A. The gene encoding HSPA12A maps to 10q26.12, a cytogenetic region that might represent a common susceptibility locus for both schizophrenia and bipolar affective disorder; reduced expression of HSPA12A has been shown in the prefrontal cortex of subjects with schizophrenia. HSPA12A is also a candidate gene for forelimb-girdle muscular anomaly, an autosomal recessive disorder of Japanese black cattle. HSPA12A is predominantly expressed in neuronal cells. It may play a role in the atherosclerotic process.
Links
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Statistics
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PSSM-Id: 212685
Aligned: 4 rows
Threshold Bit Score: 1010.34
Created: 6-Apr-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:nucleotide binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # ####                                                                     
O43301        57 VVVAVDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPERKFHSFGYAARDFYHDLDPNEAKqWLYL 136 human
DAA14757     125 VVVAIDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPERKFHSFGYAARDFYHDLDPNEAKqWLYL 204 cattle
XP_002941887  54 VVVAIDFGTTSSGYAYSFSKEPECIHIMRRWEGGDPGVSNQKTPTTMLLMPDRKFHSFGFAARDFYHDLDPSESKhWLYF 133 western clawed ...
XP_421779    118 VVVAIDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPERKFHSFGYAARDFYHDLDPSESKhWLYF 197 chicken

Feature 1           #                                                               #            
O43301       137 EKFKMKLHTTgDLTMDTDLTAANGKKVKALEIFAYALQYFKEQALKELSDQAGSEFEnsDVRWVITVPAIWKQPAKQFMR 216 human
DAA14757     205 EKFKMKLHTTgDLTMDTDLTAANGKKVKALEIFAYALQYFKEQALKELSDQAGSEFEnsDVRWVITVPAIWKQPAKQFMR 284 cattle
XP_002941887 134 EKFKMKLHSStDLTMETELTAANGKRVKALEIFAYALQYFKEQALKELSDQAGSEMDsaEVRWVITVPAIWKQPAKQFMR 213 western clawed ...
XP_421779    198 EKFKMKLHTTsNLTMETDLTAANGKKVKALEIFAYALQFFKEQALKELSDQAGSDFEntEVRWVITVPAIWKQPAKQFMR 277 chicken

Feature 1                             #                                                          
O43301       217 QAAYQAGLASPENsEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSgsdtvgagftQAKEHIRRNRQSRTFLVEN 296 human
DAA14757     285 QAAYQAGLASPENsEQLIIALEPEAASIYCRKLRLHQMTDLSSKAAVNGYSssdtvgagfaQAKEHIRRNRQSRTFLVEN 364 cattle
XP_002941887 214 QAAYKAGMATPENpEQLIIALEPEGASIYCRKLRLHQMIDLSSKAAINGISptdp---efpQAKDLARRNRQSRTFLVEN 290 western clawed ...
XP_421779    278 QAAYKAGMASPENpEQLIIALEPEAASIYCRKLRLHQMIELSSRAPVNGYSpsdtigtgftQAKEHVRRNRQSRTFLVEN 357 chicken

Feature 1                          ###### #                         ##                           
O43301       297 VIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRlpeghLKELYKATGGPYGSLGVDYEFEKLLYKIFGEDFIEQFKIKRP 376 human
DAA14757     365 VIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRlpeghLKELYKATGGPYGSLGVDYEFEKLLCKIFGEDFIEQFKIKRP 444 cattle
XP_002941887 291 VIGELWSELEEGRKQRSPLELGGTLSLIIHELLc---sNKNAQSNVGGPYGSLGVDYEFEKLLCKIFGDDFIDTFKVKRP 367 western clawed ...
XP_421779    358 VIGEIWSELEEGDRYIVVDSGGGTVDMTVHQIRlpeghLKELYKATGGPYGSLGVDYEFEKLLCKIFGEDFIEQFKIKRP 437 chicken

Feature 1                  #  ##                                                                 
O43301       377 AAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTI 456 human
DAA14757     445 AAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTI 524 cattle
XP_002941887 368 AAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMNPDAMNALFKPTI 447 western clawed ...
XP_421779    438 AAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTI 517 chicken

Feature 1                                 ### ##                       #            
O43301       457 DSIIEHLRDLFQKPEVsTVKFLFLVGGFAEAPLLQQAVQAAFGdqCRIIIPQDVGLTILKGAVLFGL 523 human
DAA14757     525 DSIIEHLRDLFQKPEVsTVKFLFLVGGFAEAPLLQQAVQAAFGdkCRVIIPQDVGLTILKGAVLFGL 591 cattle
XP_002941887 448 DPIIQHLTNLFQKPEVaGVKFLFLVGGFAESPLLQQAVQQAFGdqCRVIIPHDVGLTILKGAVLFGL 514 western clawed frog
XP_421779    518 DQIVQHLSDVFDKPEVtNVKFLFLVGGFAESPLLQQAVQSAFGsrCRVIIPQDVGLTILKGAVLFGL 584 chicken

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