Conserved Protein Domain Family
Fuz_longin_1

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pfam19036: Fuz_longin_1 
First Longin domain of FUZ, MON1 and HPS1
This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.
Statistics
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PSSM-Id: 465953
Aligned: 36 rows
Threshold Bit Score: 89.9606
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008179694  58 KHIFVLSTA-GKPIYTRFGN---------------------------ENQMASLFGLMIALVSVTQDSN-DTLQSICCG- 107
1_pfamImport   1 KCLLIADSS-ADVKFVWADAafaarlhraaggvdaspeqevpaaldmDSLVYRMFAPLVASATVLETELeDSYASFECLg 79 
O16868         3 IYLLCLTTNgGLPVFTRKKGe-------------------------cENLPFSTVASLNGFHMFFKSLG-IQLEATTTSk 56  fruit fly
EFX89267       3 AYLTCQSLS-GLPLFIRRKGd-------------------------iPSLPFPLVASLNGVYTYTKTQG-AELENTCSE- 54 
EKC19893       2 RGFVVVNKI-NDVFYLDCDTeftnhinaqaveqglleagnydtkildPSMVMQLFSPLFMSQWFLIEQRkNPCTSITCEn 80 
Q7K3N1         2 NGLIVFNSA-NDVVYQKLNEplaqkirsvatt----qgllqsggsldSNILLQIFSPIVGSQRIMQCQFdNAYSSLQCEq 76  fruit fly
EEZ98699       2 KCLLIFDHL-NDVVYTKCDDkfsthiyefaslqgfvnagdgkertidDNALVQIFSPIITSQRIMSCQFgNSYTSIQCEd 80 
KDR11428       2 KCILVFDHL-NDVLYAKYNKkfskhvrklsreq-gfmpdgkdddelsNSVLIQHFSPIVTSLQLMNCQFgNSYTSVQCKd 79 
Q92902         2 KCVLVATEG-AEVLFYWTDQefeeslrlkfgq----seneeeelpalEDQLSTLLAPVIISSMTMLEKLsDTYTCFSTEn 76  human
O08983         2 KCVLVATEG-AEVLFYWTDEefaeslrlklqq----sedeeeelpvlEDQLSTLLAPVIISSMTMLEKLsDTYTCFSTEn 76  house mouse
XP_008179694 108 -------------QTRIVFLNKD--PIILVGVSQS---SEPNDQIKKQLTYVYNNIISTLTLTQLKKIFHNRT------- 162
1_pfamImport  80 -------------DGRYRAAALR--GPPLVAVSACaapHGAETDLARDIFALRRLVEFRFGLACHDSELLRKAlkp---p 141
O16868        57 qqpiqnqapadaeEWTYIWRDRE--SITLIVCGCG---VGSEQLLQTLADLVFGAIGMFITRAAEMAHATL--------- 122 fruit fly
EFX89267      55 -------------NTFVVWKEYHdtFMLCIVATDS---SLSTVHLKHILDLVSHTMVFYLGLEELVSVKN---------- 108
EKC19893      81 -------------GFIFVFKQLE--DLLIVAISREk--PDTEQFLSKKIGVFIRVVEFLFG-PVTNEMGYSVFc------ 136
Q7K3N1        77 -------------GFNLVFGELL--GFTFLKIGQ-----IPVELLGRQMGVAITLTRYCYG-ANLFAAQA---------- 125 fruit fly
EEZ98699      81 -------------GINICFDEYM--GYLFVSVAQ-----EDVQSIKKYLSVCVTIVRYLCG-PDVCQLKM---------- 129
KDR11428      80 -------------GTNVVFNQYM--GCLFVHIGL-----NNVNWLQRTLGIFITVVKHLCG-PNVSILKR---------- 128
Q92902        77 ------------gNFLYVLHLFG--ECLFIAINGDh--TESEGDLRRKLYVLKYLFEVHFGLVTVDGHLIRKElrppdla 140 human
O08983        77 ------------dNHLYVLHLFG--EYLFVAINGDh--SESEGDLRRKLCVLKYLFEVHFGLVTVDGQLIRKElrppdle 140 house mouse
XP_008179694 163 -NFDLRRLMSGSERLIDKL 180
1_pfamImport 142 gLEKRRRVWAELDATLSAL 160
O16868       123 -LDRLKKDAKKYVPIVDAI 140 fruit fly
EFX89267     109 -IERLKKDLKVCYPLIDTI 126
EKC19893     137 rRSDRWTFLQNLMKTWELL 155
Q7K3N1       126 -GAMQQELLTQCLDCYETL 143 fruit fly
EEZ98699     130 -CERRAKIATRLIDSWVKL 147
KDR11428     129 -NKSRAFLLSRLLDTWMQL 146
Q92902       141 qRVQLWEHFQSLLWTYSRL 159 human
O08983       141 eRARVWKHFQRLLGTYSYL 159 house mouse
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