7OPC,5N4W,6V9I


Conserved Protein Domain Family
Cullin

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pfam00888: Cullin 
Cullin family
Statistics
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PSSM-Id: 459983
Aligned: 344 rows
Threshold Bit Score: 148.862
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7OPC_e        66 WRKLHEAVRAVQ-S--S-TSIRYNLE-ELY------QAVENLCShk---vSPMLYKQLRQACEDHVQAQILPFREDSLD- 130
A0CFE8        15 INNLRDHIEKVLk--gEkKVYNTKETmTFY------TEIFNYIVqge-qqGQKMYDLFKGYNEDFLKESEKIARQSLKS- 84  Paramecium tetr...
EAY01000      15 LEEISKSITSIL----ThKHSSLSLS-YLY------NCMNNLVNns---cTNKLRDTLQNHLDKQFSKQYNSLSKTALV- 79 
A0BYN1        18 WKYLDDACYLIA----EhQTKQLSFA-ELY------QHAYKLILnk---fGDFAYSQLQISIHNVVDKLISPL-NISND- 81  Paramecium tetr...
Q236H3        55 WDVIEQAIQMIY----EkKTHTLSYQ-ELY------HHAYILAFyg---hGDQAYSRLKSLLEKYSLKMLNTLGYYDSE- 119 Tetrahymena the...
7_pfamImport   1 WDKLSDTVEKVIt--aA-PLARPVWN-DKF------SDIYSLCIaypealGENLYSATKSFLSAHVKKLSK---DV-H-- 64 
ESO08238      14 WPRILDVVEKVLa--gR-TVEKSVWN-DRF------TDVYALCVsfpealAERLYAKTKEFIENHVLNLSK---SL-E-- 77 
CBJ31794      15 WVLLESSLITILqDlgQ-GFPNDLWI-SLY------TGVYKLCTkpmdpqHSKLYARLKETLELYVAGVLKGL-LAFDNa 85 
XP_002127386  11 WGRLSDTVQKVIt--aA-PLPRPVWN-DKF------SDIYSLCIaypealGESLYKETKTFLTSHVQHLCK---DV-C-- 74  vase tunicate
XP_001014520  79 LDRVRRNLKTGE----AiKISNEEYC-KLQseirntD-QFNLIG-----------NWHKEQILNYVNS------I----- 130 Tetrahymena the...
7OPC_e       131 SVL----F-L------------KkinTCWQDHCRQMIMIRSIFLFLDR------------------------TYVlqnS- 168
A0CFE8        85 DKN----F-I------------EeilYQHEIYEIHTRILQSYFTYLDRsfvev--------------lnntsQY------ 127 Paramecium tetr...
EAY01000      80 -NP----L-V------------IkfsKHCSYFASFLKILPKLYSRYDEsla------------------ensEY------ 117
A0BYN1        82 -DQ----L-L------------YdfvQAFEEVQHFSKLLAGILLYMEK------------------------SYilqk-- 117 Paramecium tetr...
Q236H3       120 -EQ----I-L------------VkmvAVWQDYKQMINILKGIFLYLDN------------------------NYvttk-- 155 Tetrahymena the...
7_pfamImport  65 -HCge-dF-L------------TsyaKNWETYSQGAVYLNLLYHHFNHqyvtkskqndadieygfitddkeqML------ 123
ESO08238      78 -ECsedvF-L------------EtynSHWLMYSRGCGYLNQLFGYLNTqyipklkieieknfsgllpesdekLL------ 137
CBJ31794      86 TAHsyteL-L------------VryrTSFHNYSVGMHYGSDWFKYLDRhwintnhce-------tgvspkegVY------ 139
XP_002127386  75 -ARet-dL-L------------SsyaKHWKTYSQGAMYLNLLYHHFNHqyvrkskqsdvdieygfvvddkeqML------ 133 vase tunicate
XP_001014520 131 --K----IdLdsktnvpeeeyiKlisKHYYDFQILVMWIQKFLMSHET------------------------FYF---Ka 177 Tetrahymena the...
7OPC_e       169 --T----LPSIWDM-----GLELFRTHII-S-DKmvqSKTIDGILLLIERERSg--------EaVD----Rs-LLRSLLG 222
A0CFE8       128 ---------PNLKQqakkqFYEQFYNKLFfS--------IKEEFKAKLKLDRi--------------------LLDKESQ 170 Paramecium tetr...
EAY01000     118 ---------RTEKI-----LFTKFKEKVLnQ-TKv-vDLIIKSMIDVIEDAR------------TNrivsGtaNLRQIIE 169
A0BYN1       118 ------slkTIKTI-----CNESFKIKCFeKdQNl-aNKLLNCFLSQIRNDR-------------NsqfiEhfKLKKALQ 172 Paramecium tetr...
Q236H3       156 ------nlqPVLVL-----GYEVFQQILFiQkSEi-ySKVLEIILTMIDKQRLge-------------niEgqLIQKIIQ 210 Tetrahymena the...
7_pfamImport 124 ---------EIKDL-----AMEAWKEGML-V--Pl-qHRLVNALLKDIAKDREgdls-gkntK----------IHQVALY 174
ESO08238     138 ---------EIEEL-----SYNIWRTHLL-E--Nc-kHQLTSLILRDINLDRIgsgl--inqS----------TIQGAIL 187
CBJ31794     140 ---------FVREM-----SLMVWKERVF-E--Al-kERLRHNTMKVINAARernlsnlddnD----------AVRSLLK 191
XP_002127386 134 ---------EIKDL-----AMEAWREGML-D--Pl-qHRLVSTILRDIARDREgkl---ggeS----------VHQVALY 182 vase tunicate
XP_001014520 178 qlQttcfKK----------SFEFFRDEYF---LGl-kDRLIEKVFKFVQKAR-------------QnvdvPkeELKRVVQ 230 Tetrahymena the...
7OPC_e       223 ML----S--DL---------------------------Q--VYK----------DSFELKFLEETNCLYAAEGQRLMQer 257
A0CFE8       171 LLlqrvY--KI------------------------------IYGmktfqdignnQLIQKEIKEDSKTYYQQQYSNFQQq- 217 Paramecium tetr...
EAY01000     170 LF----Y----------------------------------EYKnsncd-rsifENFMASLKESTKKKYEN---EYNSse 207
A0BYN1       173 IL----I--DLnqeqqiknkey------nytidyrindD--FYK----------HFLERKLIQDSRSYFKEESQSNLNkm 228 Paramecium tetr...
Q236H3       211 MS----V--DLgmkaniqkcnqy---srqiqyeyipelT--IYE----------KYFEKGYLDCSEKYFSEESQRLILql 269 Tetrahymena the...
7_pfamImport 175 SL----V--AVeqhk--------------------krnAlkYYE----------DTFEKLFLQQTGEYYRAKALELLNds 218
ESO08238     188 SF----V--HVrkha--------------------srnSldYYQ----------KNFEKEMLLQTSEHYQIVARKHLDtc 231
CBJ31794     192 TY----E--TLgfe---------------------krdRshLFQ----------TELEDFLVTDTGRYYSRRGSDLLQhm 234
XP_002127386 183 SL----V--AVeqhkk--------------------rnalkYYE----------DVFEKLFLQETGDFYRAKALELRDds 226 vase tunicate
XP_001014520 231 IY----DdqDFgndirieedrqshklrvisdsssnkqsN--NYV----------DLFEKPYLVEIEKHFQK-QASLWTdk 293 Tetrahymena the...
7OPC_e       258 evpeYLNHVSKRL---EEEGDRVI--------TY-LDHSTQ-------KP-LIACVEKQLLGEHL--------------- 302
A0CFE8       218 ---sFLDQIKSLVqfkQEELGRIRlifgceqsE--L------------QKeLIDLFNNYIINSYA--------------- 265 Paramecium tetr...
EAY01000     208 nfveFLKRIKELL---DFEEN------------LlL--KAIfkdeedvNE-ILMIAHESAIFKNTetfanqkdfqvppiy 269
A0BYN1       229 tieeYILFVEKRY---LDEVDRVQ--------HY-IPKISH-------QK-VLDCFIKIYITSNA--------------- 273 Paramecium tetr...
Q236H3       270 spkdYIIAVERRF---LEEKKRVH--------SY-FYQTSK-------NK-IQSLFFQKYINDFA--------------- 314 Tetrahymena the...
7_pfamImport 219 tcseYMNKVLSLL---TDEEMRNR--------RF-LHISSY-------KK-TTLECQQRVIIDHI--------------- 263
ESO08238     232 tcseYMTKALQML---DEETMRSK--------KF-FHATSQ-------DK-VLEVFRQRVVADHM--------------- 276
CBJ31794     235 svprYLQEVERYL---QEEASRCE--------SF-VGSYSA-------RR-ILVAAQEALIKAHS--------------- 279
XP_002127386 227 tcseYMNKILSLL---TDEEMRSR--------RF-LHISSY-------KK-TTLECQQRVIIDHI--------------- 271 vase tunicate
XP_001014520 294 ttpeYVQEALIAL---NKEEQLCQ--------DY--YPRSM-------NP-INQTINGIIIKDQT--------------- 337 Tetrahymena the...
7OPC_e       303 TAILQKG---LDHLLd--------------EnRVPDLAQMYQLFSRV----RGG-------------QQALLQHWSEYIK 348
A0CFE8       266 SDLNSDNndtLKNIIiq------------dY--YEQFGQLVKFFDHFksntHI-----------------FVRKFQEIII 314 Paramecium tetr...
EAY01000     270 SALQDK------NLLrwlirdsylrfhqknhiMCEFIPKICEFMTKD--------------------IKSFEPKFSDHMK 323
A0BYN1       274 ------------QHIsqglyd----fieneK--TAIIIIIFQLFVKSeefdL------------------FVKTFSQIII 317 Paramecium tetr...
Q236H3       315 KAIVDNQengLFNWLdn------------dE--VVIIKKSHTLFQNTkesyTI-----------------FLNIFYKYVA 363 Tetrahymena the...
7_pfamImport 264 KFLQAG----CRQMIr--------------HnSTTDLLHMYMLLKSVa----nG-------------LTHMVSELEAHIK 308
ESO08238     277 SFMHQS----SKLMVk--------------ThNKIDLSNMYNLLHSVq----dG-------------LNELIEQIEMEIG 321
CBJ31794     280 SRLVEE----ARGMLsa------------sPeKRVDLRRLFTLISYLe----dGetrggggavennaMKALEEVVRDHVR 339
XP_002127386 272 KFLQAG----CRQMIr--------------HnSATDLHHMYMLLKSVs----nG-------------LTHMVSELEAHIK 316 vase tunicate
XP_001014520 338 QYLLEHst-gIENMLkn------------gK--DNEMKDLYKLLCRVkeslAQ-----------------LGQKVRTYYQ 385 Tetrahymena the...
7OPC_e       349 TFG-TAIVIN-----------------------------PEKDKDMVQDLLDFKDKVDHVI--EVCFQ------Kn---- 386
A0CFE8       315 QQG-QEIIVEqknrisq---------------tkikqekEDQKSKFLEQLISLQQSYKKLI------------------- 359 Paramecium tetr...
EAY01000     324 ln-----------------------------------dkITQIHEIIKKVLSQTEPFEFVFcsQEHMRkksddpNfdmek 368
A0BYN1       318 DDL-QILNQNan--------------------------tLQGFIKLYEKIFSLYDKIAQYGnnEHQYK------------ 358 Paramecium tetr...
Q236H3       364 HQT-SALAARq----------------------------STPVKEYIEDIILFRLKIINIM--QEAFF------S----- 401 Tetrahymena the...
7_pfamImport 309 ETGlELVKGIk---------------------------eGNIPLQFVETILEVHKRFHDLI--RDTFN------Sd---- 349
ESO08238     322 HLCtDVICRLd---------------------------gDNMAQQFVESLLEVHNDYTQLI--QEVFK------Sd---- 362
CBJ31794     340 SVGlTVVKDLqakgamdvsddeagvrdndllpagggkaaVVTSDDVVAAMLEVYEHYKGLM--ADSFD------Ss---- 407
XP_002127386 317 ETGlDLVKGIk---------------------------eGNVPLQFVETILEVHKRFHDVI--RDTFH------Sd---- 357 vase tunicate
XP_001014520 386 ----SCISQKckdakekisafk------pdktknirdftKETAIEWVKGLIEFKIFVDNQI--STLFS------Nd---- 443 Tetrahymena the...
7OPC_e       387 ---ERFVNL---------MKESFETFI-Nk-----------rPNKPAELIAKHVDSKLR---A-G--NKEA-T-DEELER 434
A0CFE8       360 -----YDHAennqfllanLRVAFEMITaN----------------AEQH--FIMESLLQklhTfT--LKRi---DIGEEK 411 Paramecium tetr...
EAY01000     369 earEKFEKA---------ITAGWNIPAfN----------------IVENFVQYIDFHIKnekKrL---------SKTENE 414
A0BYN1       359 -----FHKA---------IKNAFEQVI-Nkdnf------immE------LNIYFDFLMK---K-------EtLrDEEKKL 401 Paramecium tetr...
Q236H3       402 -----LLKTddqltiqrqTQKSFEDSL-Nds----------nF--PTEQLNCYIDEAFQkdfK----NKS----EQQIEE 455 Tetrahymena the...
7_pfamImport 350 ---KLFVSA---------LDRACIAAV-Nyse-------pkqPCKAPELVCKYCDAILR---R-C--AKGp-S--SDADD 400
ESO08238     363 ---QQFITA---------LDKAFNKAV-NqspqqssgrltcvAMRSPELLAKYCDNLLK---R-G--GKTv-N-EYELDE 421
CBJ31794     408 ---PGFRAV---------LDEACKSFV-Na------------vPQASEWLARYAHCLLD---K-GfkESKv-D-EGTRQE 456
XP_002127386 358 ---KLFVSA---------LDRACTAVV-Nysd-------pkqQCRAPELVCKYCDAILR---R-C--TKGp-S--NDADE 408 vase tunicate
XP_001014520 444 ---LELQKA---------RDNAFQISLrEfk-------------eSPHFLSQYCDDLMK-----------QqLtDHESND 487 Tetrahymena the...
7OPC_e       435 TLDKI-MILFRFIH-GKDVFEAFYKKDLAKRLLVGKSASVDAE-KSMLSKLKHECGA-AFTSKLEGMFKDMELSKDIMV- 509
A0CFE8       412 QLKEV-MQLLECFQ-AKDLLLRNYQNKLAQRILTLFDYHSDFD-KQIIDQFRKTYGP-EHTKQLESMIKDYEQQKNEEKi 487 Paramecium tetr...
EAY01000     415 NFERTcARFFRYTE-DKVGFCTTYEQALLQRLIKFLTKF-DAEeRMMIETISKEKQP-EFMKGYKDLKACIDNSAQIDD- 490
A0BYN1       402 QIDKG-FLIFKLVQ-SKDEFEQIYRKHLCVRLLDQTYSSLEVE-KDLLKKLRLECGS-VLTHKMETMFSDLERSSEDSQ- 476 Paramecium tetr...
Q236H3       456 VLNSV-FEIFCLIR-NKDYFASIYMKSLAKRILYNKSLDENNE-KQIISKFKLECGT-VYTKKMETMFLDMQQSLEYYN- 530 Tetrahymena the...
7_pfamImport 401 KLQSS-ILVFRYID-DKDVFQKFYSRALAKRLVHTPC-AMDME-EMMINRLKGVCGY-DFTSKLHCMFTDVRLSTDLMQ- 474
ESO08238     422 KLQAS-ITIFKYLN-DKDVFNKFYARMLAKRLIYFQSQSMDAE-ESMINRLKQVCGY-EFTNKLHRMFTDISISADLAS- 496
CBJ31794     457 SLDHV-GFLFAYIA-DKDIFHKYYSKLLSKRIIQLTSVSDEAE-ERMLKNMRKISGF-EYTSKLQRMFVDKTLSRDLHT- 531
XP_002127386 409 KLQSS-ILVFRYID-EKDVFQKFYSRALARRLIHSPC-AMDME-EMMINRLKGVCGY-DFTSKLHCMFTDVRLSTELGK- 482 vase tunicate
XP_001014520 488 RQIEV-NAIFDYMNtSRDEFLLHYQQALCRRLIGFTSKSMAAE-KQIVTKFKNSVGAlPTLNRLQNMLTDVETNE----- 560 Tetrahymena the...
7OPC_e       510 HFKQHMQn----QSDsgpID------LTVN-------------------------------------------------- 529
A0CFE8       488 TISD--------------IE------IQAK-------------------------------------------------- 497 Paramecium tetr...
EAY01000     491 DFKK-----------------------QI--------------------------------------------------- 496
A0BYN1       477 KFRQKLS-----QNQrdsID------LDIL-------------------------------------------------- 495 Paramecium tetr...
Q236H3       531 EFKQLFIknlntKSAyksLD------FDIK-------------------------------------------------- 554 Tetrahymena the...
7_pfamImport 475 KYHQSSGkd--gESPqtsIN--------VN-------------------------------------------------- 494
ESO08238     497 KFTSFNQs---rNVDl-gLG------FTIL-------------------------------------------------- 516
CBJ31794     532 GYVE----------W------------QVRgggigggggggrgggggwgggglgagaegeggfvypaglvqlpmhfeaft 589
XP_002127386 483 KYQETVAkt--eDSSqpsIN--------VN-------------------------------------------------- 502 vase tunicate
XP_001014520 561 QYNK---------------EkvqndiLKIY-------------------------------------------------- 575 Tetrahymena the...
7OPC_e       530 -ILTMGYWPTYTPM-E------------------VHLTPEMIKLQEV-FKAFYLGKHSGRKLQWQTTLGHAVLKAEFKE- 587
A0CFE8       498 -ILQKEYWPEIRPQlNld---------------nILILNQLKAAYREkFNSQQEK-NQLIDISWQDQLSMVELMFRTNQe 560 Paramecium tetr...
EAY01000     497 -MNTKIEWPDGMREvQfspivfnknhyklyiieqTKIPEFLSPVHDR-FIQFYQEKNKSMTLMLLADTSTVQSKWRIPKn 574
A0BYN1       496 -VLTSEQWPITDSQp-------------------IIIHTELLLWQQQ-FTQYYQSKNSKRKLSFNYGLGSVSLKATFDQ- 553 Paramecium tetr...
Q236H3       555 -VLTCGNWPYKLNQfSq-----------------VKIPNQLEPYISE-FEKHYKSKFKGRKLKWIYSVGKSIVKG-YYSf 614 Tetrahymena the...
7_pfamImport 495 -VLQAGAWP--Lsan----------------qveFVLPESLHKCLLH-FEEFYNKKFNGRNLSWLHHLSQADVRINFTT- 553
ESO08238     517 -VLQAGAWP--IGqqn---------------ittFCLPQELEKPVHM-FEKFYAKNFTGRKLTWVYAFSQCEVKVCYLA- 576
CBJ31794     590 fVLTAGCWP--LQsvs----------------ssFKPPAPIEDYVVS-FLDFYSEVHSGRKLEWLYHLGHGEMVTHCFD- 649
XP_002127386 503 -VLQAGAWP--Ltan----------------qveFVLPETLHRCLKQ-FEEFYNHKFNGRNLSWLHHLSQAEVRINFTS- 561 vase tunicate
XP_001014520 576 -VLNSVAWPLKRNElEk-----------------IIFPSSFAGIIDQ-FTKQYNQTYKQRKIFWLFNEGSAEINF-TSAn 635 Tetrahymena the...
7OPC_e       588 ----GKK--EFQVSLFQTLVLL-MF-N-EGD---GFSFEEIKMATGIEDSELRRTLQSLacgkAR-V---LIKSPk---- 647
A0CFE8       561 --------yKVIIGVVGGAILL-QF-N---HqnnPQTSEQLAQSIGVNNQYFLNQIKLLe---SKkL---LTRD------ 615 Paramecium tetr...
EAY01000     575 sksnKPEtyVLTTDILTSKILSyLHkNqTE----KVSVQDIIMYTQEEKPLVKKCIAKL-------LglqICV-Rektvk 642
A0BYN1       554 -----NSkkDFVCSVFQATILM-HF-NkQR----VYKVDELIKLTNSDKEIMQYELENL-------LqfkLLI------- 608 Paramecium tetr...
Q236H3       615 ----NNSkkEFQVSNVQMVILL-LF-NnKI----KYTQQELTALLQMPYEEYKLHLLPL-------VqlkILK------- 670 Tetrahymena the...
7_pfamImport 554 -----KPy-lVTMSTFQLAVVI-LF-NdA-T---ELSLSEISENTKLKSRDLERNVVALi--dAN-I---LVKke----- 610
ESO08238     577 -----RPy-fISMATYLMSLLL-PF-NsA-D---CITRKELEEHTGIPEKELLKNLQALl--dVK-F---LIAdh----- 633
CBJ31794     650 -----KTy-rIYSSTFQMGLLH-QF-NdS-T---EIAVSELARGINVSDTEIVRHLFPLi--kAG-L---LRLHGadgad 711
XP_002127386 562 -----KPy-lVSMSTYQLAIIL-LF-NeS-I---ELTVSDISQNTKLKDKDLERNIAALt--dAN-I---LLKtt----- 618 vase tunicate
XP_001014520 636 k-ktFAGkyILRTTSYQMLILM-KM-NeKA----SITIQDLMDQTGINKDSFDNNLKQL-------IklkILS------- 694 Tetrahymena the...
7OPC_e       648 ----G-K-EVEDGDKF------IFNGEF 663
A0CFE8       616 ------------GQAY------KFNEEF 625 Paramecium tetraurelia
EAY01000     643 ttekQqQqQLSDTDLI------MMNKEF 664
A0BYN1       609 --------QNEEENSL------QLNQKF 622 Paramecium tetraurelia
Q236H3       671 ----SeN-----NIDF------EYNDQF 683 Tetrahymena thermophila SB210
7_pfamImport 611 ----qeK-KLDEHSVV------CVNMKF 627
ESO08238     634 ----dkD-GLCENTIF------KLNVNY 650
CBJ31794     712 lkptScD-DIPPGARA------RLNASF 732
XP_002127386 619 ------qeKLEDMSVI------RVNNKF 634 vase tunicate
XP_001014520 695 ----CaE-----EDKYtesstvQVNAQF 713 Tetrahymena thermophila SB210
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