2A8J


Conserved Protein Domain Family
Taspase1_like

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cd04514: Taspase1_like 
Click on image for an interactive view with Cn3D
Taspase 1 (threonine aspartase 1) and similar proteins
Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A threonine residue acts as the active site nucleophile in both endopeptidease and protease activities to cleave polypeptide substrates after an aspartate residue. The Taspase1 proenzyme undergoes autoproteolysis into alpha and beta subunits. The N-terminal residue of the beta subunit is a threonine which is the active catalytic residue. The active enzyme is a heterotetramer.
Statistics
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PSSM-Id: 271336
Aligned: 87 rows
Threshold Bit Score: 163.211
Created: 2-Nov-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 6 residue positions
Conserved feature residue pattern:X X X X T [VI]Click to see conserved feature residue pattern help
Evidence:
  • Structure:2AJ8: Human Taspase1 binds chloride ion inhibitor; contacts at 4.5A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ##                                                    ##                  
2A8J_A     42 GFVLVHAGAgyhsesk--akeykhvCKRACQKAIEKLQAg-ALATDAVTAALVELEDSPFTNAGMGSNLNLl---GEIEC 115 human
ETV78704    2 WFVAVHIGAgnhestnaavdeantcMRVALEAAARVLSAg-GDAVSACEEAVVVLEDAECTNAGCNGPQVNlttdGRVET 80  Aphanomyces astaci
EQC26936    2 WAVAVHIGAgrhaadaastalaeasMRDALELAGCLLRDg-ASATVAATAAVRVLEDAACTNAGSNGPCVNltetGVIET 80  Saprolegnia diclin...
EIW63309   13 RIVAVHGGAgfhprsqssdgeikraLRLACARSLAALER--EAALHAVTDAIAVLEDEECLNAGYGSNLTMs---GIVEC 87  Trametes versicolo...
EMD37889    7 YLIAVHGGAghhpass--daqvkraLKSACTTALSTLAQg-SSALNGVEDAITILENDECLNAGYGSNLTLc---GGVEC 80  Ceriporiopsis subv...
EPS97728    9 YIVAVHGGAgvhssqt--dpqvklaLKLSCKKALSLLQRg-QTSLDATQDAVTSLEVDGCLNAGYGSNLTLa---GDVEC 82  Fomitopsis pinicol...
EIW83269    8 VYLAVHGGAgyhsres--eaqvkraLKRACTETLKSIDVsmCSALDLVERAVTILEDEDCLNAGLGSNLTEs---GTVEC 82  Coniophora puteana...
ETW80874   10 YLVAVHGGAgahppsa--daatkdaLRRAARAALLSLATnpMDALSALTHAVMTLEDAEPLNAGFGSNLTLa---GRVEC 84  Heterobasidion irr...
ESK96574    2 SFIAVHGGAgnhsva-----nesllKRSMRRACRKALEA--RFALDMVEHAIADLEDDELFNAGYGSNLTFd---GTTEC 71  Moniliophthora ror...
EJF65318   10 QIIAVHGGAgfhpkst--dlevkhaLRLACSRAIEAFTRerGVALPAVCEAISALEEDECLNAGYGSNLTLr---GTVEC 84  Dichomitus squalen...
Feature 1                                                                                     
2A8J_A    116 DASIMDgksLNFGAVGALSGIKNPVSVANRLLCEGQKgklsaGRIPPCFLVGEGAYRWAVDHGIpscppnimttrfslaa 195 human
ETV78704   81 DASVMSgssNAIGCCGAVEGVRNPITLAVHLLRSQERrp--qDRQPPLFLVGHGALAEAKDANLstinyddepihpr--- 155 Aphanomyces astaci
EQC26936   81 DASIVDghsGGIGCVGAVHGVRNPIELAAALLRGADTsr-ddGRTPPMVLVGAGAVEKARALDVefvdyattpida---- 155 Saprolegnia diclin...
EIW63309   88 DASLMDgltRDFGAIGAVSGVKNPIKLAHSVLQYSRTpd-llGRIPPLLLVSAGAQEFARTRDLacipdsmisprahrew 166 Trametes versicolo...
EMD37889   81 DASLMDaqtGDFGAVGAVTGIKNPVKLARVVLEHSRRpd-plGRIPPLLLTGHGAAQFAAMSGIetvgsesqvaprvqre 159 Ceriporiopsis subv...
EPS97728   83 DASIMCgttGAFGGVGAVSGVKHPVQLARAVLEYSRRld-plGRIAPLMLVADGALQFAQAKGIvtvppgdlvapraqee 161 Fomitopsis pinicol...
EIW83269   83 DASIMDgstGDFGSVGAVSGVKNPIRAARAVLEHSREpd-plGRIRPMTLVGAGAHTFAHSSGIeivppeslissrakad 161 Coniophora puteana...
ETW80874   85 DASLMDgrsGVFGGVGAVSGVRHPIAAARAVLEGRRTkdavlGRVPPLLVVGDGAALLAGVRRVdpesmvsprarrewqv 164 Heterobasidion irr...
ESK96574   72 DASVMDg-sQGFGGVGSVSGIKNPVCLARRVLEYSRTvd-plGRIPPLFLVSEGAKSFASRHYDpkksmlvpseslvspk 149 Moniliophthora ror...
EJF65318   85 DASIMDgrnGNFGAIGSVSGVRYPIKLAHEVLLYSRKpd-plGRTPPLLLVSSGASEFAESYGLrcppqsmvsrraqgew 163 Dichomitus squalen...
Feature 1                                                       ##                            
2A8J_A    196 fkrnkrklel------------aervdtdfmqlkkrrqssekendsgTLDTVGAVVVDheGNVAAAVSSGGLALKhPGRV 263 human
ETV78704  156 -----------------------------------alikhqdnatryLLDTVGAICIDsaGHAAAAVSSAGIALKrPGRV 200 Aphanomyces astaci
EQC26936  156 -----------------------------------talrkhalmqshSLDTVGAVVVDvhGHMAAAASSAGIALKaPGRV 200 Saprolegnia diclin...
EIW63309  167 krwtdaletar---------hahpmdtmletssavglqhpqtdglhdRQDTVGAIALDaeGNLAAGVSSGGLLLKlPGRV 237 Trametes versicolo...
EMD37889  160 wshwksilds-----------ataastqqdsqytnqsildaaeslyaLQDTVGAVAWDqlSGLSAGVSSGGLLLKhPGRI 228 Ceriporiopsis subv...
EPS97728  162 wkhwknvlqsvspsyrvaegpidcptvvrddesalssigtdnaglhnVQDTVGAIACDasGSFSAGVSSGGLLLKhPGRI 241 Fomitopsis pinicol...
EIW83269  162 wtkwtm-------------------rlerskaggpavddseslpeeaMQDTVGAVVLDarGNMAACVSSGGLLLKySGRV 222 Coniophora puteana...
ETW80874  165 wka-------------------------rmaqggaqgpwgdveglhsRQDTVGAVVWDssGGLAAGVSSGGLLLKsPGRV 219 Heterobasidion irr...
ESK96574  150 sken-----------------------wsrwrerydrgdltpgelsdIQDTVGSVSLVg-ISSAAGVSSGGLLLKlPGRV 205 Moniliophthora ror...
EJF65318  164 vkwkneldaak----------srlsedspatpgqdappqlqvdglrdRQDTVGAVACNaeGHLAAGVSSGGLLLKlPGRV 233 Dichomitus squalen...
Feature 1                                                                                     
2A8J_A    264 GQAALYGCGCWAENtgahnpysTAVSTSGCGEHLVRTILARECSHALQae-------------daHQALLETMQNKFIss 330 human
ETV78704  201 GHAGCPRMGCCASNgsst-saaYAFSCTGRGEHLVQGALLQHLERQVAsmsakaqvndvindafnDAKSSNAGVAIEGgv 279 Aphanomyces astaci
EQC26936  201 GPAGCPRMGCVAWNatqs-pngYAWAATGRGEEIMRTGLLQQLEGRFRrktal-------daatiDHNLTRAFNDAAAln 272 Saprolegnia diclin...
EIW63309  238 GEAAMYGAGCWATHr-------VSCSVSGAGEDITRASLAKTICSSVEaage----------dgdIHDVLQTVIGHQFhk 300 Trametes versicolo...
EMD37889  229 GEAATYGAGCWANMtpdr-nraVACSVSGAGEYIIRTLLARKIAETIIfsdpn-------dthdvLGRILQQFHEDCRar 300 Ceriporiopsis subv...
EPS97728  242 GEAAMFGAGCWATSpkdegiggVACSVSGAGEHITRAALARSVVEAVDvpn------------adTHETIRRILLSGLrg 309 Fomitopsis pinicol...
EIW83269  223 GEAAIFGAGCWAQQssa---ggMACSVSGGGEHIARCSLARALGEALHdp-------------cdAHEVLQDVLTRKFsr 286 Coniophora puteana...
ETW80874  220 GEAAIFGAGCWADDv-------LACSVSGTGELIVQSALARALADALAasp-----------apdAHETLRTVLVDRFyd 281 Heterobasidion irr...
ESK96574  206 GEACIFGSGCWAEDtee---csVAVSVSGAGEHIMRASLARTLSKAIVsetp----------dadPHDIIHRVFKEEFwi 272 Moniliophthora ror...
EJF65318  234 GEAAIYGAGCWATHk-------TACSVSGAGEYITRMSLARALCEAIEaagd----------dtdTHEVLQRVLGEDFlq 296 Dichomitus squalen...
Feature 1                                                                                     
2A8J_A    331 pfl-asedgVLGGVIVLRscrcsaepdssqnkqtllVEFLWSHTTESMCVGYMsaqd-gkakTHISRLppgav------- 401 human
ETV78704  280 igl--igrpSSNDATNKRprl------------vdgLDFVVAFTTPSMGIGMLsssd-paphMEILRNgp---------- 334 Aphanomyces astaci
EQC26936  273 h-----dvgVEGGVLGLLrapsts------hgssrkRRREEASSSKSKVAARLpathvvaafTTPSMGlgvy-------- 333 Saprolegnia diclin...
EIW63309  301 vcaergetsPQAGVILLVkeydd--------dgqlrPRLWCAFTTESMAIGYAssvs--skpSVRPSLhp---------- 360 Trametes versicolo...
EMD37889  301 g-----epdPHAGVLLLLreqsa--------egviiPRLWCAFTTESMAIAYAlsld-akpqVRLATR------------ 354 Ceriporiopsis subv...
EPS97728  310 arhgpedglPHAGILLLMrervg--------eatsvPRLWCAFTTESMAIAYAssmd-pkpkKKLGKSvidewpygrslq 380 Fomitopsis pinicol...
EIW83269  287 plqargerdPQAGMLLLTkease--------sgdtrARLWCGFTTKTMAVGYAtwpg-ssprIKVLRRe----------- 346 Coniophora puteana...
ETW80874  282 fwtargedePNAGVLLLTkerdg---------arctPRLWCAFTTPSMAIAYAsslnpkpqpIPEGRSig---------- 342 Heterobasidion irr...
ESK96574  273 pikrlgedhPNAGILLLLrqg-------------dtARLWCAFTTPSMAIAFAsasn-pkpkTFILRQsk---------- 328 Moniliophthora ror...
EJF65318  297 lcsdrgepsPQAGVLLLVkeer-----------srdDSANVGHDSDMDSDSDGngd---dsnTDKSDRg----------- 351 Dichomitus squalen...
Feature 1                     
2A8J_A    402 -agqsVAIEGGVCRLE 416 human
ETV78704  335 ---tgGLLSAHVCAVP 347 Aphanomyces astaci
EQC26936  334 -csddSAPRAQIVRSM 348 Saprolegnia diclina VS20
EIW63309  361 ----aTAVLEAPRPSG 372 Trametes versicolor FP-101664 SS1
EMD37889  355 -----THLNSCEHRVM 365 Ceriporiopsis subvermispora B
EPS97728  381 asaciDNQNGSRGAVH 396 Fomitopsis pinicola FP-58527 SS1
EIW83269  347 ----tTSAGDDESHLY 358 Coniophora puteana RWD-64-598 SS2
ETW80874  343 ---lrVAHRWSMAWCE 355 Heterobasidion irregulare TC 32-1
ESK96574  329 ---psSALDEPPLFIT 341 Moniliophthora roreri MCA 2997
EJF65318  352 ----gNSHGGRPAFKP 363 Dichomitus squalens LYAD-421 SS1

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