1BXI,7CEI


Conserved Protein Domain Family
HNHc
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cd00085: HNHc 
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HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.
Links
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Statistics
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PSSM-Id: 238038
Aligned: 121 rows
Threshold Bit Score: 27.8212
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:consensus: e-x-h-H-i-x-p-x(2,4)-g-x(5,6)-N-l-x(3)-t-p-x(2,3)-H-x(3)-h ; capitalized letters are most conserved
  • Comment:residues involved in phosphate and metal binding
  • Structure:1BXI_B, E9 DNAse
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      # ### #           ##   ##  #   
1BXI_B     51 DDFRKAVWeevskdpelsknlnpsnkssvsKGYSpftpknqqvggrkVYELHHDKPIsqggEVYDXDNIRVTTPKRHIDI 130 Escherichia coli
140066     46 MFHRWVWEqh-------------------kGPIPd------------GYEIDHICLNr---GCCNVEHLQCIPKRDHIIK 91  Bacteriophage T3
1085762    54 TIHRLVALhf-------------------cEGYGe------------DLVVDHIDQDr---DNNHCSNLRWVSRKENSNN 99  Bacteriophage phi-E
140446     15 ELTREDYSa--------------------dRNSPqy----------nLFCSHHINPKfn-kGGDEPENLVLLHYFEHAYV 63  Chlamydomonas moew...
9631656   140 LIHQLMGEtr-------------------fVPKPygm--------psNWTVHHIDNDp---SNNHCDNLVWASPETQRKE 189 Paramecium bursari...
465641     54 QVHRLVAIhf-------------------cEGYEe------------GLVVDHKDGNk---DNNLSTNLRWVTQKINVEN 99  Bacteriophage SPO1
9631990    58 QVHNLIALa--------------------fIKKPddf--------neTFTIDHIDRNp---LNNSVSNLRWVNKHVQLEN 106 Paramecium bursari...
140120     27 TPHRHIYEet-------------------yGPVPt------------GIVVMHICDNp---RCYNIKHLTLGTPKDNSED 72  Bacteriophage T7
472887     55 YVHRLVALaf-------------------lCRPPg------------KELINHIDGDk---TNNYFKNLEWCDHKENLMH 100 Bacteriophage SPP1
9630589    50 LLHKVITRa--------------------fLGDT-------------TLTVDHIDGNk---NNNKLSNLEYVTQAENTRR 93  bacteriophage bIL170

Feature 1     #
1BXI_B    131 H 131 Escherichia coli
140066     92 T 92  Bacteriophage T3
1085762   100 I 100 Bacteriophage phi-E
140446     64 H 64  Chlamydomonas moewusii
9631656   190 Q 190 Paramecium bursaria Chlorella virus 1
465641    100 Q 100 Bacteriophage SPO1
9631990   107 R 107 Paramecium bursaria Chlorella virus 1
140120     73 M 73  Bacteriophage T7
472887    101 A 101 Bacteriophage SPP1
9630589    94 M 94  bacteriophage bIL170

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